{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:46:34Z","timestamp":1792590394789,"version":"4.5.0"},"reference-count":56,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T00:00:00Z","timestamp":1667952000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T00:00:00Z","timestamp":1667952000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Hyperthyroidism is a common endocrinopathy affecting middle-aged to elderly cats, with multisystemic repercussions. Hyperthyroid humans show decreased lung compliance and increased cardiac output with subsequent left heart failure leading to pulmonary capillary congestion. Prognosis worsens with the development of increased pulmonary vascular pressures (ie, pulmonary hypertension [PH]) in hyperthyroid humans. The effect of excess thyroid hormone concentration on pulmonary arterial hemodynamics is unknown in cats. Assessing pulmonary vascular pressures in veterinary medicine relies heavily on echocardiographic measurements performed at the level of the heart and pulmonary trunk. This study investigated right-sided cardiac and pulmonary arterial hemodynamics in hyperthyroid cats using echocardiography.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Echocardiographic examinations of hyperthyroid cats identified through a bi-institutional database search were reviewed for the determination of systolic pulmonary arterial pressure (PAP) and 20 other metrics. Values were compared with those of a healthy cat group using non-parametric statistical analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Systolic PAP could not be determined in 23\/26 hyperthyroid and 13\/14 healthy cats owing to unmeasurable tricuspid regurgitation flow velocity. Hyperthyroid cats were roughly twice as old (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001) and had 2\u20134-fold higher respiratory rates (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001) than healthy cats. Hyperthyroid cats showed an increase in acceleration time-to-ejection time ratio of pulmonary flow (1.4-fold,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.001), pulmonary artery velocity time integral (1.2\u20131.6-fold,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.001), maximal pulmonary velocity (1.3\u20131.7-fold,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.002), stroke volume (1.5-fold,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.001) and cardiac output (1.6-fold,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001) vs healthy cats. None of the other echocardiographic metrics reached statistical significance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and relevance<\/jats:title>\n                    <jats:p>Systolic PAP estimation proved unsuitable as a sole measurement for the assessment of PH in hyperthyroid cats owing to the frequent inability to interrogate tricuspid regurgitant flow velocity. Hyperthyroid cats have altered echocardiographic measures of pulmonary hemodynamics dissimilar to those reported in hyperthyroid humans. Differential effects of thyrotoxic cardiomyopathy on ventricular systolic function may underlie species differences.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1098612x221127102","type":"journal-article","created":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T11:35:26Z","timestamp":1667993726000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["No evidence of pulmonary hypertension revealed in an echographic evaluation of right-sided hemodynamics in hyperthyroid cats"],"prefix":"10.1177","volume":"24","author":[{"given":"Laury","family":"Lachance","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Montr\u00e9al, Saint-Hyacinthe, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9r\u00e9nice","family":"Conversy","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Montr\u00e9al, Saint-Hyacinthe, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Wiggen","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Surgery, University of Missouri Veterinary Health Center, College of Veterinary Medicine, University of Missouri, Columbia, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Pavard","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Montr\u00e9al, Saint-Hyacinthe, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Reinero","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Surgery, University of Missouri Veterinary Health Center, College of Veterinary Medicine, University of Missouri, Columbia, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7899-9385","authenticated-orcid":false,"given":"Isabelle","family":"Masseau","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Montr\u00e9al, Saint-Hyacinthe, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,11,9]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X12464462"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X16643252"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.21825\/vdt.v85i5.16325"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-003-0060-7"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200102153440707"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2005.11.023"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-1877"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2018.06.1055"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjms.2017.01.016"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-016-0923-8"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00115.2014"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00196511"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2003.tb00143.x"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.228.10.1495"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2006.tb01826.x"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.233.9.1441"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1997.tb03472.x"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1999.tb03044.x"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2011.01064.x"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2006.11.004"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/vru.12106"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1177\/1040638717723686"},{"key":"e_1_3_3_24_2","volume-title":"Small animal cardiovascular medicine","author":"Kittleson MD","year":"1998","unstructured":"Kittleson MD, Kienle RD. 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