{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:46:56Z","timestamp":1792590416857,"version":"4.5.0"},"reference-count":37,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The purpose of this study was to evaluate the correlation between clinical aspects and urethral lesions with reproductive status and age at neutering in obstructed male cats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>All cats with compatible signs of urethral obstruction (UO) treated at the Veterinary Hospital of the Federal Rural University of Pernambuco from 2019 to 2021 were divided into three groups according to their reproductive status: intact; prepubertal neutered; and post-pubertal neutered. Cats with compatible signs of UO were selected for further analysis. Age, clinical signs, age at neutering and age of the first obstructive event were documented. Cats with recurrent obstructive urinary signs or urethral trauma that made catheterization impossible were referred for perineal urethrostomy. The morphology of the excised penises was assessed by histopathological analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 84 cats with signs of UO included in this study, 28.6% were classified as intact, 28.6% as prepubertal neutered and 42.8% as post-pubertal neutered. Intact cats had a significantly earlier onset of UO compared with prepubertal and post-pubertal neutered cats, as seen by the age at obstruction (3.6 vs 5.7 and 5.5 years, respectively). Similar clinical signs and histopathological lesions were observed in all groups. The main clinical signs observed were stranguria, hematuria and pollakiuria. All cats had some degree of injury in the penile urethra. The most common lesions were hemorrhage, fibrosis and congestion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and relevance<\/jats:title>\n                    <jats:p>It appears that intact cats had an earlier onset of UO than neutered cats, regardless of age at neutering. Urethral histopathological lesions and clinical signs were similar in both groups. Pediatric neutering represents a useful tool in the control of abandoned and stray animals and the consequent dissemination of zoonoses, thus having a positive impact on public health.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1098612x221128781","type":"journal-article","created":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T08:41:10Z","timestamp":1669884070000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Neutering is not associated with early-onset urethral obstruction in cats"],"prefix":"10.1177","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6383-2232","authenticated-orcid":false,"given":"Keytyanne de Oliveira","family":"Sampaio","sequence":"first","affiliation":[{"name":"Faculty of Veterinary Medicine, Federal Rural University of Pernambuco, Recife, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1894-7337","authenticated-orcid":false,"given":"Valdemiro Amaro da","family":"Silva-Junior","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Federal Rural University of Pernambuco, Recife, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8074-6651","authenticated-orcid":false,"given":"Reginaldo Pereira","family":"de Sousa-Filho","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Ceara State University, Fortaleza, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grazielle Anahy de Sousa","family":"Aleixo","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Federal Rural University of Pernambuco, Recife, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6658-7797","authenticated-orcid":false,"given":"Marina Gabriela Monteiro Carvalho","family":"Mori da Cunha","sequence":"additional","affiliation":[{"name":"Laboratory of Translational Genetics, Department of Human Genetics, KU Leuven, Leuven, Belgium"},{"name":"VIB Center for Cancer Biology, VIB, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8935-6553","authenticated-orcid":false,"given":"Ellen Cordeiro Bento","family":"da Silva","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Federal Rural University of Pernambuco, Recife, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,12,1]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X15594842"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1534-6935.2003.00100.x"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.71.7.840"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2007.06.007"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.237.11.1261"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.243.8.1140"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2010.12.012"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12254"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X19888808"},{"key":"e_1_3_2_11_2","first-page":"483","article-title":"Medical management of feline urethral obstruction.","volume":"26","author":"Osborne CA","year":"1996","unstructured":"Osborne CA, Kruger JM, Lulich JP, et al. Medical management of feline urethral obstruction. J Feline Med Surg 1996; 26: 483\u2013498.","journal-title":"J Feline Med Surg"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12278"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2001.218.1429"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X16689405"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-56968-w"},{"key":"e_1_3_2_16_2","first-page":"975","article-title":"Feline urological syndrome: associations with some time, space, and individual patient factors.","volume":"37","author":"Willeberg P","year":"1976","unstructured":"Willeberg P, Priester WA. Feline urological syndrome: associations with some time, space, and individual patient factors. J Am Vet Med Assoc 1976; 37: 975\u2013978.","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2011.08.001"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/vr.102678"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X19867777"},{"key":"e_1_3_2_20_2","volume-title":"Canine and feline theriogenology","author":"Johnston SD","year":"2001","unstructured":"Johnston SD, Kustritz MVR, Olson PNS. Canine and feline theriogenology. Philadelphia, PA: WB Saunders, 2001."},{"key":"e_1_3_2_21_2","first-page":"1125","article-title":"Development of spermatogenic function in the sex maturation process in male cats.","volume":"66","author":"Tsutsui T","year":"2004","unstructured":"Tsutsui T, Kuwabara S, Kuwabara K, et al. Development of spermatogenic function in the sex maturation process in male cats. Theriogenology 2004; 66: 1125\u20131127.","journal-title":"Theriogenology"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1080\/00480169.2012.738591"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2000.217.1661"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2004.224.372"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.1996.57.03.371"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.12681\/jhvms.14846"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12924"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2018.00207"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X15587955"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X16660605"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2010.10.006"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.56808\/2985-1130.2432"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/132.6.1730S"},{"key":"e_1_3_2_34_2","article-title":"Obstru\u00e7\u00e3o uretral em gatos machos \u2013 revis\u00e3o liter\u00e1ria.","volume":"4","author":"Galv\u00e3o ALB","year":"2010","unstructured":"Galv\u00e3o ALB, Ondani AC, Fraz\u00edlio FO, et al. Obstru\u00e7\u00e3o uretral em gatos machos \u2013 revis\u00e3o liter\u00e1ria. Acta Vet Bras 2010; 4. DOI: 10.21708\/avb.2010.4.1.1446.","journal-title":"Acta Vet Bras"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.5380\/avs.v19i4.35881"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.1996.tb01244.x"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2007.09.002"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2012.11.015"}],"container-title":["Journal of Feline Medicine and Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1098612X221128781","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1098612X221128781","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1098612X221128781","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:21:12Z","timestamp":1792588872000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1098612X221128781"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":37,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1177\/1098612X221128781"],"URL":"https:\/\/doi.org\/10.1177\/1098612x221128781","relation":{},"ISSN":["1098-612X","1532-2750"],"issn-type":[{"value":"1098-612X","type":"print"},{"value":"1532-2750","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12]]}}}