{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T10:57:52Z","timestamp":1784804272508,"version":"3.55.0"},"reference-count":41,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100020648","name":"Universidade Estadual de Santa Cruz","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020648","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of this study was to evaluate the expression profile of sex steroid receptors and redox mediators in the uterus of domestic cats with pyometra.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Twelve cats were used and divided into groups: (1) non-gestational healthy diestrus (n\u2009=\u20097) and (2) pyometra (n\u2009=\u20095). The plasma profiles of estradiol and progesterone (P\n                      <jats:sub>4<\/jats:sub>\n                      ) as well as uterine expression levels of estradiol alpha (ER\u03b1), progesterone (PR) and androgen (AR) receptors, of the antioxidant enzymes superoxide dismutase 1 (SOD1), catalase and glutathione peroxidase 1 (GPX1), and of the oxidative damage marker 8-hydroxy-2\u2032-deoxyguanosine (8-OHdG) were evaluated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Cats with pyometra showed higher plasma P\n                      <jats:sub>4<\/jats:sub>\n                      levels and increased uterine messenger RNA (mRNA) and protein expression of ER\u03b1 and PR, mainly in the glandular epithelium for ER\u03b1 and in stromal and myometrial cells for PR. In addition, there was an increase in 8-OHdG immunostaining and GPX1 mRNA and protein expression in cats with pyometra compared with those in non-gestational diestrus, while catalase showed a reduction in endometrial immunostaining in cats with pyometra. There were no differences in uterine AR and SOD1 expression between the groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and relevance<\/jats:title>\n                    <jats:p>The findings of this study showed that pyometra is associated with oxidative stress in the uterus of domestic cats and alterations of the profile of sex steroid receptors, especially ER\u03b1 and PR, and of antioxidant enzymes, suggesting that changes in these mediators may play a role with the etiopathogenesis of this disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1098612x231170159","type":"journal-article","created":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T05:46:35Z","timestamp":1701236795000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Pyometra alters the redox status and expression of estrogen and progesterone receptors in the uterus of domestic cats"],"prefix":"10.1177","volume":"25","author":[{"given":"Ac\u00e1cia Eduarda de Jesus","family":"Nascimento","sequence":"first","affiliation":[{"name":"Centro de Microscopia Eletr\u00f4nica, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Estadual de Santa Cruz, Ilh\u00e9us, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano Cardoso","family":"Santos","sequence":"additional","affiliation":[{"name":"Centro de Microscopia Eletr\u00f4nica, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Estadual de Santa Cruz, Ilh\u00e9us, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca Reis","family":"Santos","sequence":"additional","affiliation":[{"name":"Centro de Microscopia Eletr\u00f4nica, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Estadual de Santa Cruz, Ilh\u00e9us, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilly Oliveira","family":"Santos","sequence":"additional","affiliation":[{"name":"Centro de Microscopia Eletr\u00f4nica, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Estadual de Santa Cruz, Ilh\u00e9us, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Clara da Silva Galr\u00e3o","family":"Cunha","sequence":"additional","affiliation":[{"name":"Centro de Microscopia Eletr\u00f4nica, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Estadual de Santa Cruz, Ilh\u00e9us, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola Pereira das Neves","family":"Snoeck","sequence":"additional","affiliation":[{"name":"Hospital Veterin\u00e1rio, Departamento de Ci\u00eancias Agrarias e Ambientais, Universidade Estadual de Santa Cruz, Ilh\u00e9us, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rio S\u00e9rgio Lima","family":"de Lavor","sequence":"additional","affiliation":[{"name":"Hospital 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