{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T00:11:35Z","timestamp":1794010295899,"version":"4.8.0"},"reference-count":132,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Clinical relevance:<\/jats:title>\n                    <jats:p>Invasive fungal infections (IFIs) and oomycoses (hereafter termed invasive fungal-like infections [IFLIs]) are characterised by penetration of tissues by fungal elements. The environment is the most common reservoir of infection. IFIs and IFLIs can be frustrating to treat because long treatment times are usually required and, even after attaining clinical cure, there may be a risk of relapse. Owner compliance with medication administration and recheck examinations can also decline over time. In addition, some antifungal drugs are expensive, have variable interpatient pharmacokinetic properties, can only be administered parenterally and\/or have common adverse effects (AEs). Despite these limitations, treatment can be very rewarding, especially when an otherwise progressive and fatal disease is cured.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>In the second of a two-part article series, the spectrum of activity, mechanisms of action, pharmacokinetic and pharmacodynamic properties, and AEs of antifungal drugs are reviewed, and the treatment and prognosis of specific IFIs\/IFLIs - dermatophytic pseudomycetoma, cryptococcosis, sino-orbital aspergillosis, coccidioidomycosis, histoplasmosis, sporotrichosis, phaeohyphomycosis, mucormycosis and oomycosis - are discussed. Part 1 reviewed the diagnostic approach to IFIs and IFLIs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Evidence base:<\/jats:title>\n                    <jats:p>Information on antifungal drugs is drawn from pharmacokinetic studies in cats. Where such studies have not been performed, data from \u2018preclinical\u2019 animals (non-human studies) and human studies are reviewed. The review also draws on the wider published evidence and the authors\u2019 combined expertise in feline medicine, mycology, dermatology, clinical pathology and anatomical pathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abbreviations for antifungal drugs:<\/jats:title>\n                    <jats:p>AMB (amphotericin B); FC (flucytosine); FCZ (fluconazole); ISA (isavuconazole); ITZ (itraconazole); KCZ (ketoconazole); PCZ (posaconazole); TRB (terbinafine); VCZ (voriconazole).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1098612x231220047","type":"journal-article","created":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T06:05:46Z","timestamp":1704693946000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Invasive fungal infections and oomycoses in cats 2. Antifungal therapy"],"prefix":"10.1177","volume":"26","author":[{"given":"Vanessa R","family":"Barrs","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Sciences, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Kowloon Tong, Hong Kong, SAR China"},{"name":"Centre for Animal Health and Welfare, City University of Hong Kong, Kowloon Tong, Hong Kong, SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Hobi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Kowloon Tong, Hong Kong, SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angeline","family":"Wong","sequence":"additional","affiliation":[{"name":"Shatin Animal Hospital, Tai Wai, New Territories, Hong Kong, SAR 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