{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T16:38:20Z","timestamp":1792341500589,"version":"4.4.0"},"reference-count":72,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Mammary tumours in cats are biologically aggressive. The standard of care relies upon wide surgical resection. Chemotherapy has been described in the macroscopic disease setting; however, limited efficacy has been shown. The aim of this study was to assess the efficacy of toceranib phosphate in macroscopic feline mammary tumours (FMTs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 17 cats with cytologically or histopathologically confirmed mammary adenocarcinoma (gross disease) were prospectively enrolled. Toceranib phosphate was administered at a median dose of 2.77\u2009mg\/kg (range 2.3\u20133.2) PO q48\u2009h. No corticosteroids or non-steroidal anti-inflammatory drugs (NSAIDs) were administered. Toxicity was graded according to Veterinary Cooperative Oncology Group\u2013Common Terminology Criteria for Adverse Events (VCOG-CTCAE) v1.1 criteria. The response was assessed after 1 month, following Response Evaluation Criteria In Solid Tumours (RECIST) criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Toxicity was observed in eight cats, with most instances being grade 1 or 2, which were managed with supportive care. Only one cat experienced grade 3 toxicity (anorexia), which resolved after a dose reduction. Clinical benefit was seen in 12 (64.7%) cats and an objective response was seen in six (35.2%) cats. One cat experienced complete response, five had partial response, six had stable disease and five had progressive disease. One cat showed distant progression (malignant pleural effusion) despite continued partial remission of the primary tumour. The median progression-free survival and median overall survival time were 91 days (range 30\u2013158) and 145 days (range 31\u2013234), respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and relevance<\/jats:title>\n                    <jats:p>Toceranib phosphate showed clinical benefit and a good safety profile in advanced or recurrent FMTs, offering a new alternative in the treatment of this disease; however, further prospective and randomised studies are required to further assess its efficacy. Interestingly, one cat developed distant metastases while the primary tumour showed partial response, suggesting that primary tumour and metastatic disease may not sustain the same sensitivity to toceranib.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1098612x241256473","type":"journal-article","created":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T09:10:35Z","timestamp":1725009035000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Evaluation of the efficacy and safety of toceranib phosphate in cats with macroscopic mammary adenocarcinoma"],"prefix":"10.1177","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-4284-4651","authenticated-orcid":false,"given":"Isabel","family":"Del Portillo Miguel","sequence":"first","affiliation":[{"name":"Hospital for Small Animals, The Royal (Dick) School of Veterinary Studies, The University of Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Blackwood","sequence":"additional","affiliation":[{"name":"Hospital for Small Animals, The Royal (Dick) School of Veterinary Studies, The University of Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Maiques","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias Biom\u00e9dicas, Facultad de Ciencias de la Salud, Universidad Cardenal Herrera-CEU, CEU Universities, Alfara del Patriarca, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5564-6912","authenticated-orcid":false,"given":"Ignacio","family":"P\u00e9rez Roger","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias Biom\u00e9dicas, Facultad de Ciencias de la Salud, Universidad Cardenal Herrera-CEU, CEU Universities, Alfara del Patriarca, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9416-8047","authenticated-orcid":false,"given":"Enric","family":"Poch Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias Biom\u00e9dicas, Facultad de Ciencias de la Salud, Universidad Cardenal Herrera-CEU, CEU Universities, Alfara del Patriarca, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Borrego","sequence":"additional","affiliation":[{"name":"Oncology Service, Hospital A\u00fana Especialidades Veterinarias, IVC-Evidensia, Paterna, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,8,30]]},"reference":[{"key":"bibr1-1098612X241256473","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X13483237"},{"key":"bibr2-1098612X241256473","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2010.08.010"},{"key":"bibr3-1098612X241256473","doi-asserted-by":"publisher","DOI":"10.1177\/0300985813488894"},{"key":"bibr4-1098612X241256473","doi-asserted-by":"publisher","DOI":"10.1186\/bcr790"},{"key":"bibr5-1098612X241256473","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X15610367"},{"key":"bibr6-1098612X241256473","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2020.12.008"},{"key":"bibr7-1098612X241256473","doi-asserted-by":"publisher","DOI":"10.2460\/javma.252.11.1393"},{"key":"bibr8-1098612X241256473","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2009.10.030"},{"key":"bibr9-1098612X241256473","first-page":"709","volume":"70","author":"Weijer K","year":"1983","journal-title":"J Natl Cancer Inst"},{"key":"bibr10-1098612X241256473","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2008.0244.x"},{"key":"bibr11-1098612X241256473","doi-asserted-by":"publisher","DOI":"10.5326\/0420110"},{"key":"bibr12-1098612X241256473","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.58.723"},{"key":"bibr13-1098612X241256473","first-page":"157","volume":"187","author":"Jeglum KA","year":"1985","journal-title":"J Am Vet Med Assoc"},{"key":"bibr14-1098612X241256473","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1988.tb02794.x"},{"key":"bibr15-1098612X241256473","first-page":"618","volume-title":"Withrow & MacEwen\u2019s small animal clinical oncology","author":"Sorenmo KU","year":"2020","edition":"6"},{"key":"bibr16-1098612X241256473","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5829.2009.00194.x"},{"key":"bibr17-1098612X241256473","first-page":"1045","volume":"9","author":"Stolwijk JA","year":"1989","journal-title":"Anticancer Res"},{"key":"bibr18-1098612X241256473","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X14567159"},{"key":"bibr19-1098612X241256473","unstructured":"Henry CJ, Higginbotham ML, Rodriguez C, et al. 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