{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T17:08:50Z","timestamp":1788541730014,"version":"build-2803163510"},"reference-count":34,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100007229","name":"Bijzonder Onderzoeksfonds UGent","doi-asserted-by":"publisher","award":["DOC 2020 004701"],"award-info":[{"award-number":["DOC 2020 004701"]}],"id":[{"id":"10.13039\/501100007229","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["FWO SBP 2020 006001"],"award-info":[{"award-number":["FWO SBP 2020 006001"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to assess the impact of interlaboratory differences (in analysis technique and reference intervals [RIs]) on the measurement of serum creatinine (sCr) and serum symmetric dimethylarginine (sSDMA) concentrations in cats and on classification by stage of chronic kidney disease (CKD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>For the interlaboratory discrepancy study, samples from 30 client-owned cats (healthy or diagnosed with CKD) with sCr in the range of 130\u2013200\u2009\u00b5mol\/l and urine specific gravity &lt;1.035 were retrospectively selected. A single batch of samples was analysed for sCr and sSDMA with one in-house laboratory machine and in three commercial laboratories. In addition, sCr values from 63 healthy cats aged \u2a7e10 years were used to calculate an age-specific RI for the in-house analyser.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Despite a relatively good correlation (interclass correlation coefficient [ICC]\u2009=\u20090.875), the in-house analyser consistently reported lower sCr values, while for sSDMA, systematically higher values were obtained in one commercial laboratory (ICC\u2009=\u20090.707). A total of 22\/30 (73%) cases had at least one laboratory reporting inconsistent sSDMA values in relation to the RI, and 23\/30 (77%) for sCr. For subsequent staging using sSDMA, at least 1\/4 laboratories indicated a different stage in 22\/30 (73%) cases. For sCr, all laboratories classified the cats as stage 2; however, the in-house analyser classified 8\/30 (27%) cats as stage 1. The RI (71\u2013212\u2009\u00b5mol\/l) provided by the company for sCr measurement on the in-house machine was subsequently recalculated, resulting in a considerably lower upper limit (163\u2009\u00b5mol\/l) and a significantly (adjusted\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      value\u2009=\u20090.016) different proportion of cats with measurements outside the RI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and relevance<\/jats:title>\n                    <jats:p>Clinicians must be careful when interpreting sCr and sSDMA values, as they may lead to discrepant outcomes due to interlaboratory variability. Moreover, age-specific RIs should be applied when available, facilitating the early detection of CKD in older cats.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1098612x251320249","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T08:23:22Z","timestamp":1745915002000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of interlaboratory differences on the measurement of serum creatinine and symmetric dimethylarginine values: does this affect clinical decision-making?"],"prefix":"10.1177","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7364-032X","authenticated-orcid":false,"given":"Ellen","family":"Vanden Broecke","sequence":"first","affiliation":[{"name":"Small Animal Department, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium"},{"name":"Laboratory of Integrative Metabolomics (LIMET), Department of Translational Physiology, Infectiology and Public Health, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurens","family":"Van Mulders","sequence":"additional","affiliation":[{"name":"Small Animal Department, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium"},{"name":"Laboratory of Integrative Metabolomics (LIMET), Department of Translational Physiology, Infectiology and Public Health, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Paepe","sequence":"additional","affiliation":[{"name":"Small Animal Department, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Daminet","sequence":"additional","affiliation":[{"name":"Small Animal Department, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,4,29]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/0300985815622975"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X14536176"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X13511446"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2004.03.004"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X13495235"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X14545274"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12445"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15975"},{"key":"e_1_3_3_10_2","unstructured":"International Renal Interest Society. 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