{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T23:26:59Z","timestamp":1777850819751,"version":"3.51.4"},"reference-count":41,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine the effects of haemorrhage and fluid over-resuscitation on colloidal osmotic pressure of albumin (COP albumin), plasma (Posm) and effective (Eosm) osmolality in anaesthetised cats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A total of six cats were given three treatments once, at 2-month intervals, in a randomised, crossover haemorrhage-resuscitation study. The treatments were divided into two phases, a controlled haemorrhage phase and a fluid resuscitation phase, as follows: (1) NoHR\u2009=\u2009no controlled haemorrhage and no resuscitation; (2) LRS\u2009=\u2009controlled haemorrhage followed by lactated Ringer\u2019s solution infusion (60\u2009ml\/kg\/h); and (3) TS\u2009=\u2009controlled haemorrhage followed by 6% tetrastarch 130\/0.4 suspended in 0.9% saline infusion (20\u2009ml\/kg\/h). The resuscitation fluids were administered for 120\u2009mins. Data were collected before haemorrhage, before resuscitation and at 30\u2009min intervals until 120\u2009mins. Variables were calculated at each time point as follows: COP albumin\u2009=\u2009albumin concentration (g\/l)\u2009\u00d7\u20090.57; Posm\u2009=\u2009(2\u2009\u00d7\u2009sodium)\u2009+\u2009glucose\u2009+\u2009blood urea nitrogen; and Eosm\u2009=\u2009(2\u2009\u00d7\u2009sodium)\u2009+\u2009glucose. All Posm and Eosm concentrations were measured as mmol\/l. Data were compared using a general linear mixed model (significance:\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mean\u2009\u00b1\u2009SD total haemorrhage volumes for NoHR, LRS and TS were 10.2\u2009\u00b1\u20092.3, 29.3\u2009\u00b1\u20099.0 and 29.1\u2009\u00b1\u20096.3\u2009ml\/kg, respectively. The COP albumin decreased over time in all treatments regardless of volumes of blood lost and fluid administered. The decrease in COP albumin was profound and clinically relevant in LRS and TS (both\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001). There were no statistical differences in Posm and Eosm over time except in LRS at 90 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.004) and 120\u2009ml\/kg (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and relevance<\/jats:title>\n                    <jats:p>The COP albumin decreased in all treatments but to low and clinically relevant concentrations in LRS and TS, putting the cats at risk of fluid overload. There were no clinically relevant derangements in Posm and Eosm.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1098612x251320299","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T10:13:16Z","timestamp":1743761596000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of haemorrhage and lactated Ringer\u2019s solution or tetrastarch 130\/0.4 resuscitation on colloidal osmotic pressure and osmolality in cats"],"prefix":"10.1177","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-8592-6772","authenticated-orcid":false,"given":"Anthea","family":"Michaletos","sequence":"first","affiliation":[{"name":"Valley Farm Animal Hospital, Faerie Glen, Pretoria, Gauteng, South Africa"},{"name":"Department of Companion Animal Clinical Studies, Faculty of Veterinary Science, University of Pretoria, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4184-0876","authenticated-orcid":false,"given":"Marinell","family":"Breytenbach","sequence":"additional","affiliation":[{"name":"Valley Farm Animal Hospital, Faerie Glen, Pretoria, Gauteng, South Africa"},{"name":"Department of Companion Animal Clinical Studies, Faculty of Veterinary Science, University of Pretoria, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7653-7726","authenticated-orcid":false,"given":"Gareth E","family":"Zeiler","sequence":"additional","affiliation":[{"name":"Valley Farm Animal Hospital, Faerie Glen, Pretoria, Gauteng, South Africa"},{"name":"Department of Companion Animal Clinical Studies, Faculty of Veterinary Science, University of Pretoria, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,4,4]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/9781118923870.ch2"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/aas.13603"},{"key":"e_1_3_3_4_2","first-page":"47","volume-title":"Part 1: Volume and distribution of water and its major solutes between plasma, the interstitium and intracellular fluid","author":"Woodcock T.","year":"2024","unstructured":"Woodcock T. Fluid physiology. In: Malbrain ML, Wong A, Nasa P, Ghosh S (eds). Part 1: Volume and distribution of water and its major solutes between plasma, the interstitium and intracellular fluid. London: Springer, 2024, pp 47\u201374."},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00586651"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/9781119501237.ch36"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01274.2005"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00393.2003"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaa.2021.04.011"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000233876.87978.AB"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaa.2019.11.008"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/vec.13376"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/9781118923870.ch4"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-4431.1993.tb00102.x"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.1994.55.07.910"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaa.2021.07.004"},{"key":"e_1_3_3_17_2","first-page":"371","article-title":"Interpretation of haemodynamic measurements.","volume":"20","author":"Poole-Wilson P.","year":"1978","unstructured":"Poole-Wilson P. Interpretation of haemodynamic measurements. Br J Hosp Med 1978; 20: 371\u2013372.","journal-title":"Br J Hosp Med"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1976.03270150028025"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(70)80241-4"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-2995.2006.00326.x"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.236.3.309"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0887-2333(91)90021-5"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1053\/jfms.2000.0088"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvp.12203"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.5326\/JAAHA-MS-6630"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-2995.2006.00342.x"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-2995.2007.00388.x"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-2995.2005.00232a_11.x"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200604000-00023"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1201\/9780138719128-33"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000222469.94134.ba"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-014-0038-4"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40635-021-00407-6"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.1996.tb01407.x"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.QMH.0000267447.55500.57"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12283"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12208"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.14813"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.1992.53.12.2241"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00254796"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.244.9.1075"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1111\/vcp.12833"}],"container-title":["Journal of Feline Medicine and Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1098612X251320299","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1098612X251320299","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1098612X251320299","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:12:14Z","timestamp":1777500734000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1098612X251320299"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1177\/1098612X251320299"],"URL":"https:\/\/doi.org\/10.1177\/1098612x251320299","relation":{},"ISSN":["1098-612X","1532-2750"],"issn-type":[{"value":"1098-612X","type":"print"},{"value":"1532-2750","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4]]},"article-number":"1098612X251320299"}}