{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T18:44:20Z","timestamp":1788374660696,"version":"build-2803163510"},"reference-count":31,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec>\n                    <jats:title>Case series summary<\/jats:title>\n                    <jats:p>This case series describes nine cases of fecal microbiota transplantation in cats and associated adverse events (AEs) from two tertiary referral hospitals. AEs were graded according to criteria established by the Veterinary Cooperative Oncology Group\u2019s Common Terminology Criteria for Adverse Events (VCOG-CTCAE v2) for clinical trials. Cats received 5\u20136\u2009g\/kg donor feces 2\u20136 times for chronic enteropathy (n\u2009=\u20094) or therapy-resistant diarrhea (n\u2009=\u20095). AEs included lethargy (n\u2009=\u20097), vomiting (n\u2009=\u20095), diarrhea (n\u2009=\u20095), weight loss (n\u2009=\u20095), inappetence (n\u2009=\u20095), dehydration (n\u2009=\u20095), abdominal pain (n\u2009=\u20092), gastroenterocolitis based on ultrasound (n\u2009=\u20092) and anorexia (n\u2009=\u20091). Temperatures of up to 103.4\u00b0F were noted but did not meet the criteria for AEs (&gt;103.5\u00b0F). Cats responded to antimicrobials (metronidazole, marbofloxacin), anthelmintics (fenbendazole), supportive care with fluids, ondansetron and mirtazapine (n\u2009=\u20095), gabapentin (n\u2009=\u20092), pradofloxacin (n\u2009=\u20091) or self-resolved (n\u2009=\u20091). Positive response to fecal microbiota transplantation for the presenting complaint was seen in eight cats (seven complete, one partial and transient).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Relevance and novel information<\/jats:title>\n                    <jats:p>Fecal microbiota transplantation is increasing in usage among companion animals. Fecal microbiota transplantations in cats have been rarely described in the literature as have AEs after administration. This case series represents the first description of AEs after fecal microbiota transplantation in cats.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1098612x251337274","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T03:25:45Z","timestamp":1748575545000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Adverse events after fecal microbiota transplantation in nine cats: a case series"],"prefix":"10.1177","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6052-5288","authenticated-orcid":false,"given":"Mary Ann","family":"Lee","sequence":"first","affiliation":[{"name":"James L Voss Veterinary Teaching Hospital, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8645-0085","authenticated-orcid":false,"given":"Tanner","family":"Slead","sequence":"additional","affiliation":[{"name":"Austin Veterinary Emergency &amp; Specialty, Austin, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Suchodolski","sequence":"additional","affiliation":[{"name":"Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, Texas A&amp;M University, College Station, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8725-9530","authenticated-orcid":false,"given":"M Katherine","family":"Tolbert","sequence":"additional","affiliation":[{"name":"Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, Texas A&amp;M University, College Station, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0693-0669","authenticated-orcid":false,"given":"Sina","family":"Marsilio","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Epidemiology, UC Davis School of Veterinary Medicine, Davis, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,5,30]]},"reference":[{"key":"e_1_3_2_2_2","first-page":"71","article-title":"Commentary on key aspects of fecal microbiota transplantation in small animal practice.","volume":"7","author":"Chaitman J","year":"2016","unstructured":"Chaitman J, Jergens AE, Gaschen F, et al. Commentary on key aspects of fecal microbiota transplantation in small animal practice. Vet Med (Auckl) 2016; 7: 71\u201374.","journal-title":"Vet Med (Auckl)"},{"key":"e_1_3_2_3_2","first-page":"705","article-title":"Preliminary clinical and microbiome assessment of stool transplantation in the dog and the cat [abstract].","volume":"27","author":"Weese J","year":"2013","unstructured":"Weese J, Costa M, Webb J. Preliminary clinical and microbiome assessment of stool transplantation in the dog and the cat [abstract]. J Vet Intern Med 2013; 27: 705.","journal-title":"J Vet Intern Med"},{"key":"e_1_3_2_4_2","first-page":"35","article-title":"First case report of fecal microbiota transplantation in a cat in Israel.","volume":"72","author":"Furmanski S","year":"2017","unstructured":"Furmanski S, Mor T. First case report of fecal microbiota transplantation in a cat in Israel. Israel J Vet Med 2017; 72: 35\u201341.","journal-title":"Israel J Vet Med"},{"key":"e_1_3_2_5_2","article-title":"Microbiome responses to fecal microbiota transplantation in cats with chronic digestive issues.","volume":"10","author":"Rojas CA","year":"2023","unstructured":"Rojas CA, Entrolezo Z, Jarett JK, et al. Microbiome responses to fecal microbiota transplantation in cats with chronic digestive issues. Vet Sci 2023; 10. DOI: 10.3390\/vetsci10090561.","journal-title":"Vet Sci"},{"key":"e_1_3_2_6_2","article-title":"Observational study of small animal practitioners\u2019 awareness, clinical practice and experience with fecal microbiota transplantation in dogs.","volume":"47","author":"Schmitz S","year":"2022","unstructured":"Schmitz S. Observational study of small animal practitioners\u2019 awareness, clinical practice and experience with fecal microbiota transplantation in dogs. Top Companion Anim Med 2022; 47. DOI: 10.1016\/j.tcam.2022.100630.","journal-title":"Top Companion Anim Med"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yasa.2024.06.006"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15072"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2020.00192"},{"key":"e_1_3_2_10_2","article-title":"Clinical effects of faecal microbiota transplantation as adjunctive therapy in dogs with chronic enteropathies-a retrospective case series of 41 dogs.","volume":"10","author":"Toresson L","year":"2023","unstructured":"Toresson L, Spillmann T, Pilla R, et al. Clinical effects of faecal microbiota transplantation as adjunctive therapy in dogs with chronic enteropathies-a retrospective case series of 41 dogs. Vet Sci 2023; 10. DOI: 10.3390\/vetsci10040271.","journal-title":"Vet Sci"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-35565-y"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0250344"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2020.09.004"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-55691-w"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.16690"},{"key":"e_1_3_2_16_2","article-title":"Systematic review: adverse events of fecal microbiota transplantation.","volume":"11","author":"Wang S","year":"2016","unstructured":"Wang S, Xu M, Wang W, et al. Systematic review: adverse events of fecal microbiota transplantation. PLoS One 2016; 11. DOI: 10.1371\/journal.pone.0161174.","journal-title":"PLoS One"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/apt.16148"},{"key":"e_1_3_2_18_2","first-page":"150","article-title":"Adverse events in fecal microbiota transplantation: a systematic review and meta-analysis.","volume":"35","author":"Rapoport EA","year":"2022","unstructured":"Rapoport EA, Baig M, Puli SR. Adverse events in fecal microbiota transplantation: a systematic review and meta-analysis. Ann Gastroenterol 2022; 35: 150\u2013163.","journal-title":"Ann Gastroenterol"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2022.893342"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12677"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X15610370"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-45173-4"},{"key":"e_1_3_2_23_2","first-page":"31","article-title":"Trapianto del microbiota fecale (FMT) in 16 cani affetti da IBD idiopatica.","volume":"31","author":"Bottero E","year":"2017","unstructured":"Bottero E, Benvenuti E, Ruggiero P. Trapianto del microbiota fecale (FMT) in 16 cani affetti da IBD idiopatica. Veterinaria 2017; 31: 31\u201345.","journal-title":"Veterinaria"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.17061"},{"key":"e_1_3_2_25_2","unstructured":"National Institutes of Health National Cancer Institute. Common Terminology Criteria for Adverse Events (CTCAE) v 5.0. Accessed April 30 2025. https:\/\/ctep.cancer.gov\/protocoldevelopment\/electronic_applications\/docs\/ctcae_v5_quick_reference_5x7.pdf"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1910437"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15635"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15871"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15775"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-2995.2009.00508.x"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.10.1.19"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.16012"}],"container-title":["Journal of Feline Medicine and Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1098612X251337274","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1098612X251337274","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1098612X251337274","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T03:39:54Z","timestamp":1784086794000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1098612X251337274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1177\/1098612X251337274"],"URL":"https:\/\/doi.org\/10.1177\/1098612x251337274","relation":{},"ISSN":["1098-612X","1532-2750"],"issn-type":[{"value":"1098-612X","type":"print"},{"value":"1532-2750","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5]]},"article-number":"1098612X251337274"}}