{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T22:57:20Z","timestamp":1791845840722,"version":"4.3.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100029350","name":"American Society for The Prevention of Cruelty To Animals Professional","doi-asserted-by":"publisher","award":["No number associated"],"award-info":[{"award-number":["No number associated"]}],"id":[{"id":"10.13039\/100029350","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011179","name":"Cornell Feline Health Center","doi-asserted-by":"publisher","award":["No number associated"],"award-info":[{"award-number":["No number associated"]}],"id":[{"id":"10.13039\/100011179","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Topical treatments, along with systemic oral antifungals, are the mainstay of infection and environmental control for cats with dermatophytosis in animal shelters. This study aimed to provide realistic expectations of the performance of three commonly used topical treatments to help shelters minimize the length of stay and optimize feline welfare.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A prospective, randomized, semi-blinded clinical trial compared treatment success and time to cure for miconazole chlorhexidine (MC) and hydrogen peroxide (HP) shampoos vs lime sulfur (LS) using a non-inferiority model. Cats with\n                      <jats:italic toggle=\"yes\">Microsporum canis<\/jats:italic>\n                      were enrolled at four US animal shelters, treated with oral itraconazole and randomized into three topical treatment groups. Treatment success was defined as mycological cure by 7 weeks, while inferiority was defined as requiring more than 1 additional week to achieve cure.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 76 cats were enrolled. LS significantly outperformed both alternatives in cure by 7 weeks. Time to cure analysis showed significant differences between LS (mean 27 days, range 7\u201345) vs MC (37, 14\u201362) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.04) and LS vs HP (36, 11\u201365) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.06). Although alternative products took significantly longer to cure, confidence intervals (CIs) around the difference of means included the inferiority margin: LS vs MC (9.66, 95% CI 0.7\u201318.5) and LS vs HP (8.54, 95% CI 0.44\u201316.6). Therefore, inferiority of the alternative products was suggestive but inconclusive. After controlling for confounders, a Cox proportional hazards analysis confirmed significantly poorer performance of MC (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.003) and HP (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.032) vs LS. Younger age also significantly prolonged treatment (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.039), while intake type, co-housing and low body condition score did not. Shelter staff ratings showed no differences between products in terms of treatment unpleasantness, difficulty or cat reactions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and relevance<\/jats:title>\n                    <jats:p>\n                      In this study, LS outperformed HP and MC in treating cats with\n                      <jats:italic toggle=\"yes\">M canis<\/jats:italic>\n                      . Younger cats took a longer time to achieve cure. If shelters or practitioners wish to use an alternative topical treatment to LS, then HP should be considered.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1098612x251360611","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T04:09:07Z","timestamp":1759118947000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Randomized, non-inferiority clinical trial of three topical dermatophytosis treatments in shelter cats"],"prefix":"10.1177","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0176-9183","authenticated-orcid":false,"given":"Lena","family":"DeTar","sequence":"first","affiliation":[{"name":"Maddie\u2019s Shelter Medicine Program, Cornell University College of Veterinary Medicine, Ithaca, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyrsten Jade","family":"Janke","sequence":"additional","affiliation":[{"name":"Toronto Humane Society, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9704-8737","authenticated-orcid":false,"given":"Linda","family":"Jacobson","sequence":"additional","affiliation":[{"name":"Toronto Humane Society, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,9,28]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"1217","article-title":"Feline dermatophytosis: clinical features and diagnostic testing.","volume":"61","author":"Bajwa J","year":"2020","unstructured":"Bajwa J. Feline dermatophytosis: clinical features and diagnostic testing. Can Vet J 2020; 61: 1217\u20131220.","journal-title":"Can Vet J"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X15625709"},{"key":"e_1_3_3_4_2","doi-asserted-by":"crossref","unstructured":"Newbury S. Dermatophytosis. In: Miller L Janeczko S Hurley KF (eds). Infectious disease management in animal shelters. Wiley 2021 pp 462\u2013499.","DOI":"10.1002\/9781119294382.ch20"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X19825519"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/vr.133.3.57"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X14530213"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12842"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X14530215"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2010.00914.x"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2007.00618.x"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X17735967"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12440"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X13489222"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12069"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2009.00789.x"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2007.00568.x"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1999.tb03783.x"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1053\/jfms.2000.0093"},{"key":"e_1_3_3_20_2","first-page":"55","article-title":"Treatment of a Microsporum canis infection in a colony of Persian cats with griseofulvin and a shampoo containing 2% miconazole, 2% chlorhexidine, 2% miconazole and chlorhexidine or placebo [abstract].","volume":"12","author":"Mason K","year":"2000","unstructured":"Mason K, Frost A, O\u2019Boyle D. Treatment of a Microsporum canis infection in a colony of Persian cats with griseofulvin and a shampoo containing 2% miconazole, 2% chlorhexidine, 2% miconazole and chlorhexidine or placebo [abstract]. Vet Dermatol 2000; 12 Suppl 1: 55.","journal-title":"Vet Dermatol"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12122"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X15626197"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/853937"},{"key":"e_1_3_3_24_2","unstructured":"Sealed Envelope Ltd. Power calculator for continuous outcome non-inferiority trial. https:\/\/www.sealedenvelope.com\/power\/continuous-noninferior\/ (2012 accessed 7 March 2025)."},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-12-106"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12322"},{"key":"e_1_3_3_27_2","doi-asserted-by":"crossref","unstructured":"Moriello K Coyner K. Dermatophytosis. In: Sykes JE Greene CE (eds). Greene\u2019s infectious diseases of the dog and cat. 5th ed. Elsevier 2023 pp 961\u2013973.","DOI":"10.1016\/B978-0-323-50934-3.00078-1"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X17729286"},{"key":"e_1_3_3_29_2","first-page":"763","article-title":"Descriptive epidemiology of companion animal dermatophytosis in a Canadian Pacific Northwest animal shelter system.","volume":"61","author":"Gordon E","year":"2020","unstructured":"Gordon E, Idle A, DeTar LG. Descriptive epidemiology of companion animal dermatophytosis in a Canadian Pacific Northwest animal shelter system. 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