{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T23:27:18Z","timestamp":1777850838696,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The sedation quality of intramuscular (IM) alfaxalone and butorphanol in combination with midazolam was investigated in hyperthyroid cats undergoing suitability assessment for radioiodine treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A total of 60 hyperthyroid cats undergoing diagnostic investigations were randomly allocated to receive butorphanol (0.3\u2009mg\/kg IM) and midazolam (0.2\u2009mg\/kg IM) with either alfaxalone (2\u2009mg\/kg IM) (BMA2) or alfaxalone (3\u2009mg\/kg IM) (BMA3), or butorphanol (0.3\u2009mg\/kg IM) with alfaxalone (3\u2009mg\/kg IM) (BA3). If required, additional alfaxalone (0.2\u2009mg\/kg) was administered intravenously. Cat Stress Score, response to injection, time to lateral recumbency, sedation score at 10, 15 and 20\u2009mins and subsequent 10-min intervals, additional alfaxalone requirements, and time to first administration, recovery quality (excellent, fair, poor) and adverse effects were assessed. Thyroxine concentrations, gabapentin treatment and assessors were recorded. Heart and respiratory rate and arterial haemoglobin saturation were monitored every 5\u2009mins. Data were compared using \u03c7\n                      <jats:sup>2<\/jats:sup>\n                      and Kruskal\u2013Wallis testing. The multidimensional sedation score and predictors of sedation score were analysed using a mixed effect and linear regression model, respectively (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      No significant predictors for sedation quality were identified. In all groups, the median sedation score was considered good and the median recovery score was fair. The sedation score over time across groups and cardiorespiratory variables were not significantly different. Additional alfaxalone was administered in 53 cats. In group BA3, additional alfaxalone was required significantly earlier (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.043). Although sedated, muscle twitching was a commonly observed adverse effect in all groups, but head pawing was significantly increased in BA3 (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.014).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and relevance<\/jats:title>\n                    <jats:p>Sedation and recovery quality were satisfactory with all protocols but the addition of midazolam prolonged sedation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1098612x251364368","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T04:14:31Z","timestamp":1759119271000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Randomised clinical trial comparing intramuscular alfaxalone and butorphanol sedation with or without midazolam in hyperthyroid cats"],"prefix":"10.1177","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7801-6147","authenticated-orcid":false,"given":"Julia","family":"Deutsch","sequence":"first","affiliation":[{"name":"The Feline Centre, Langford Vets, University of Bristol, Langford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3203-7276","authenticated-orcid":false,"given":"Natalie","family":"Finch","sequence":"additional","affiliation":[{"name":"The Feline Centre, Langford Vets, University of Bristol, Langford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6430-6154","authenticated-orcid":false,"given":"Sabine","family":"K\u00e4stner","sequence":"additional","affiliation":[{"name":"Tier\u00e4rztliche Hochschule Hannover, Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4752-9246","authenticated-orcid":false,"given":"Angie","family":"Hibbert","sequence":"additional","affiliation":[{"name":"The Feline Centre, Langford Vets, University of Bristol, Langford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,9,28]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X13518939"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.13369"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X18755925"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.5326\/JAAHA-MS-7368"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-2995.2008.00428.x"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X14551187"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.14-0200"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaa.2016.05.014"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/vaa.12304"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.1996.tb00041.x"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X21996155"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0962728600019837"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1990.tb00685.x"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.12157"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1080\/00480169.2018.1455541"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X221104747"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X18760434"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X17732484"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaa.2020.02.010"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/vec.13058"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-197911000-00012"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2014.01.018"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X211064702"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-2995.2011.00699.x"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/vaa.12183"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmn.2010.03.002"},{"key":"e_1_3_3_28_2","unstructured":"Zoetis. Safety datasheet alfaxalone. https:\/\/www2.zoetis.com.au\/content\/_assets\/SDS\/Alfaxan-Multidose-Anaesthetic-Injection-SDS.pdf (2024 accessed 18 July 2024)."},{"key":"e_1_3_3_29_2","unstructured":"Goodwin WA Pasloske K. A dose ranging study evaluating the pharmacodynamics of RD0327 as an anaesthetic and sedative in rabbits after intramuscular administration [abstract]. Proceedings of the World Congress of Veterinary Anaesthesiology; 2015 Sept 1\u20134. https:\/\/wcvaa.org\/wp-content\/uploads\/2021\/05\/WCVA2015-Proceeding-Keynote-lecture-Lecture-Abstracts.pdf."},{"key":"e_1_3_3_30_2","unstructured":"Zoetis. Datasheet alfaxalone. https:\/\/www.zoetisus.com\/content\/_assets\/docs\/Petcare\/alfaxan-prescribing-information.pdf (2023 accessed 18 July 2024)."},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvp.12485"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaa.2017.10.006"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaa.2018.03.003"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.251.10.1175"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X17719399"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.20.06.0307"}],"container-title":["Journal of Feline Medicine and Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1098612X251364368","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1098612X251364368","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1098612X251364368","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:12:27Z","timestamp":1777500747000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1098612X251364368"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":35,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1177\/1098612X251364368"],"URL":"https:\/\/doi.org\/10.1177\/1098612x251364368","relation":{},"ISSN":["1098-612X","1532-2750"],"issn-type":[{"value":"1098-612X","type":"print"},{"value":"1532-2750","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9]]},"article-number":"1098612X251364368"}}