{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:15:36Z","timestamp":1791249336438,"version":"4.1.0"},"reference-count":44,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Buttons Fund for Feline Chronic Kidney Disease"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of the present study was to evaluate health-related quality of life (HRQoL) in cats with chronic kidney disease (CKD) and integrate these results with clinical data to identify factors associated with decreased HRQoL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Caregivers completed a validated HRQoL tool (VetMetrica) and clinical data (history, laboratory work, physical examination findings, etc) were collected. Vitality, comfort and emotional wellbeing (EWB) scores were compared between groups using non-parametric analyses as appropriate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Data from 24 healthy cats and 68 cats with CKD were collected. Cats with CKD had significantly lower median vitality, comfort and EWB scores (vitality: 41.7, range 4.3\u201364; comfort: 36.1, range 21.2\u201359.6; EWB: 44.6, range 1.6\u201358.8) than healthy cats (vitality: 56.5, range 40.7\u201364; comfort: 59.6, range 34.2\u201359.6; EWB: 58.7, range 45.1\u201358.8) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.0001 for all analyses). Cats with International Renal Interest Society (IRIS) stage 3 and 4 CKD had lower median EWB scores (30.8, range 1.6\u201354.4) than IRIS stage 1 and 2 CKD (47.3, range 11.2\u201358.8) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.04) and lower vitality scores (38.2, range 4.3\u201354.0) in comparison with IRIS stage 1 and 2 CKD (43.1, range 12.8\u201364.0) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.04). Cats with anaemia had lower median EWB scores (25.9, range 10.4\u201354.4) than those without (46.6, range 1.6\u201358.8) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.005), and haematocrit was positively correlated with EWB (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.005,\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      \u2009=\u20090.33). Cats with abnormal appetite had lower median EWB scores (29.1, range 1.6\u201356.7) than cats with normal appetite (48.1, range 11.2\u201358.8) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.001). Cats with constipation had lower median comfort scores 29.5 (range 21.2\u201359.5) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.0003) and lower median EWB scores (22, range 1.6\u201358.8) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.008) than those without (comfort: 37.1, range 25.3\u201359.6; EWB: 47.9, range 11.2\u201358.8).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and relevance<\/jats:title>\n                    <jats:p>Cats with CKD have decreased HRQoL. Several modifiable clinical factors are associated with this decreased HRQoL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1098612x251367535","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T09:50:38Z","timestamp":1757670638000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Evaluation of health-related quality of life in cats with chronic kidney disease"],"prefix":"10.1177","volume":"27","author":[{"given":"Sarah K","family":"Lorbach","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1388-0452","authenticated-orcid":false,"given":"Jessica M","family":"Quimby","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eline","family":"Nijveldt","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rene E","family":"Paschall","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E Marian","family":"Scott","sequence":"additional","affiliation":[{"name":"University of Glasgow, Glasgow, Scotland, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1673-9083","authenticated-orcid":false,"given":"Jacqueline","family":"Reid","sequence":"additional","affiliation":[{"name":"University of Glasgow, Glasgow, Scotland, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,9,12]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0277-9536(95)00112-K"},{"key":"e_1_3_3_3_2","first-page":"195","volume-title":"Epidemiology and demography in public health","author":"Hays RD","year":"2010","unstructured":"Hays RD, Reeve BB. 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