{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T17:08:48Z","timestamp":1788541728788,"version":"build-2803163510"},"reference-count":33,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100012752","name":"Elanco Animal Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012752","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of the study was to evaluate the efficacy and safety of capromorelin to manage weight loss in cats with unintended weight loss, as occurs in chronic kidney disease (CKD), in a randomized, masked, placebo-controlled, multicenter clinical field study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 176 client-owned cats with existing CKD and unintended weight loss of 5% or more were enrolled. Cats were randomized 2:1 to receive capromorelin or a vehicle placebo orally once daily for 55 days. Changes in body weight and safety parameters were monitored throughout the study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Body weight increased progressively with time in the capromorelin group and decreased in the placebo group. For the effectiveness population data sample (n\u2009=\u2009112), mean change in body weight from day 0 to day 55 was +5.18% (95% confidence interval [CI] 3.45\u20136.91) with capromorelin and \u20131.65% (95% CI \u20133.82 to 0.55) with placebo. The treatment effect (capromorelin minus placebo) from day 0 to day 55 was +6.81% (95% CI 4.21\u20139.42) with\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.0001, representing +0.25\u2009kg (95% CI 0.15\u20130.35) body weight. Hypersalivation was observed only in the capromorelin group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.0001). For all other adverse events (AEs), there was no significant difference between the treatment groups: in the capromorelin group 96\/118 (81.4%) cats and in the placebo group 41\/58 (70.7%) cats had at least one reported AE (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.3650).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and relevance<\/jats:title>\n                    <jats:p>Capromorelin was safe and effective, and provides a valuable new option to maintain or increase body weight in cats with CKD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1098612x251379924","type":"journal-article","created":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T10:27:32Z","timestamp":1762597652000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Capromorelin promotes weight gain in cats with unintended weight loss: a randomized, masked, placebo-controlled clinical trial"],"prefix":"10.1177","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6524-715X","authenticated-orcid":false,"given":"Jessica A","family":"Wofford","sequence":"first","affiliation":[{"name":"Elanco Animal Health, Indianapolis, IN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3171-5648","authenticated-orcid":false,"given":"April","family":"Milliken MacKinnon","sequence":"additional","affiliation":[{"name":"Milliken Associates, Manhattan, KS, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2825-1007","authenticated-orcid":false,"given":"Ernst","family":"Heinen","sequence":"additional","affiliation":[{"name":"Elanco Animal Health, Indianapolis, IN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,11,8]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2011.00838.x"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X19851303"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X13511446"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/vr.105100"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.14561"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2020.03.006"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/vms3.83"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.3389\/fragi.2025.1549453"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-0016"},{"key":"e_1_3_3_11_2","article-title":"Measurement of ghrelin as a marker of appetite dysregulation in cats with and without chronic kidney disease.","volume":"10","author":"Brusach K","year":"2023","unstructured":"Brusach K, Lorbach S, Quimby J, et al. Measurement of ghrelin as a marker of appetite dysregulation in cats with and without chronic kidney disease. Vet Sci 2023; 10. DOI: 10.3390\/vetsci10070464.","journal-title":"Vet Sci"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2003-0381"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.12.8111"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12023"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-0632"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-149-9-200811040-00003"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2017.07.023"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx192"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)00558-6"},{"key":"e_1_3_3_20_2","unstructured":"Food and Drug Administration Center for Veterinary Medicine. Freedom of Information Summary NADA 141-536. EluraTM capromorelin oral solution cats. https:\/\/animaldrugsatfda.fda.gov\/adafda\/app\/search\/public\/document\/downloadFoi\/9908 (2020 accessed 30 September 2025)."},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvp.12459"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-8-18"},{"key":"e_1_3_3_23_2","unstructured":"International Renal Interest Society. IRIS staging of CKD. https:\/\/www.iris-kidney.com\/s\/2_IRIS_Staging_of_CKD_2023.pdf (2023 accessed 30 September 2025)."},{"key":"e_1_3_3_24_2","first-page":"13","article-title":"Development and validation of a body condition score system for cats: a clinical tool.","volume":"25","author":"Laflamme D.","year":"1997","unstructured":"Laflamme D. Development and validation of a body condition score system for cats: a clinical tool. Feline Pract 1997; 25: 13\u201318.","journal-title":"Feline Pract"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.72.4.433"},{"key":"e_1_3_3_26_2","unstructured":"World Small Animal Veterinary Association Global Nutrition Committee. Muscle Condition Score. https:\/\/wsava.org\/wp-content\/uploads\/2020\/01\/Muscle-Condition-Score-Chart-for-Cats.pdf (2014 accessed 30 September 2025)."},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/52.3-4.591"},{"key":"e_1_3_3_28_2","article-title":"Capromorelin oral solution (ENTYCE\u00ae) increases food consumption and body weight when administered for 4 consecutive days to healthy adult Beagle dogs in a randomized, masked, placebo controlled study.","volume":"13","author":"Zollers B","year":"2017","unstructured":"Zollers B, Rhodes L, Heinen E. Capromorelin oral solution (ENTYCE\u00ae) increases food consumption and body weight when administered for 4 consecutive days to healthy adult Beagle dogs in a randomized, masked, placebo controlled study. BMC Vet Res 2017; 13. 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