{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:35:24Z","timestamp":1792787724842,"version":"4.5.0"},"reference-count":27,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T00:00:00Z","timestamp":1758758400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T00:00:00Z","timestamp":1758758400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Gallant Therapeutics"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The present study evaluated the safety and efficacy of intravenous, allogeneic uterine-derived mesenchymal stem cells (UMSCs) for client-owned cats with refractory feline chronic gingivostomatitis (FCGS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a 90-day prospective, multi-site, baseline-controlled, clinical trial involving 46 cats with refractory FCGS after partial- or full-mouth extractions. Cats received two doses of 20 million UMSCs, 14 days apart. Effectiveness was evaluated at days 14, 28, 60 and 90 using owner-reported assessment of overall response (ORA), client-specific outcome measures (CSOM) of quality-of-life improvement and veterinarian-assessed global oral lesion score (GOLS) tissue healing. Safety assessments included clinical observations and clinical pathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Treatment success rates at days 28, 60 and 90 were 61.4% (27\/44), 76.3% (29\/38) and 78.8% (26\/33) for CSOM; 65.9% (29\/44), 73.7% (28\/38) and 75.8% (25\/33) for ORA; and 31.8% (13\/44), 47.5% (18\/38) and 45.5% (15\/33) for GOLS. CSOM and GOLS on day 14 after a single dose were 52.3% (23\/44) and 25.0% (11\/44), respectively. Cats treated within 6 months of tooth extraction had greater improvement in GOLS. There were no statistically significant differences in outcomes between cats with partial- or full-mouth extractions. Adverse events were generally mild and transient, with most related to underlying disease. All six serious adverse events were either unlikely to be due to, or in one case inconclusively attributed to, UMSC therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and relevance<\/jats:title>\n                    <jats:p>Repeated intravenous UMSC therapy was well tolerated and demonstrated clinically meaningful improvement in quality of life in cats with refractory FCGS within 2 weeks of treatment. In addition, oral lesions continued to improve over time. These results support the safe and effective use of UMSCs for this life-threatening condition.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1098612x251385852","type":"journal-article","created":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T03:44:36Z","timestamp":1758858276000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Clinical field study evaluating the safety and efficacy of allogeneic uterine-derived mesenchymal stem cells for refractory feline chronic gingivostomatitis"],"prefix":"10.1177","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-8862-3021","authenticated-orcid":false,"given":"Valentine S","family":"Williams","sequence":"first","affiliation":[{"name":"Gallant, San Diego, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica L","family":"Schneider","sequence":"additional","affiliation":[{"name":"Gallant, San Diego, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolph S","family":"Parrish","sequence":"additional","affiliation":[{"name":"Vista Research, Bath, ME, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caryn M","family":"Thompson","sequence":"additional","affiliation":[{"name":"Vista Research, Bath, ME, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn","family":"Wrightson","sequence":"additional","affiliation":[{"name":"Gallant, San Diego, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nopmanee","family":"Taechangam","sequence":"additional","affiliation":[{"name":"Gallant, San Diego, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orzala","family":"Sharif","sequence":"additional","affiliation":[{"name":"Gallant, San Diego, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2272-3966","authenticated-orcid":false,"given":"Maria","family":"Soltero-Rivera","sequence":"additional","affiliation":[{"name":"Department of Surgical and Radiological Sciences, University of California, Davis, CA, USA"},{"name":"Veterinary Institute for Regenerative Cures, School of Veterinary Medicine, University of California, Davis, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7289-8994","authenticated-orcid":false,"given":"Boaz","family":"Arzi","sequence":"additional","affiliation":[{"name":"Department of Surgical and Radiological Sciences, University of California, Davis, CA, USA"},{"name":"Veterinary Institute for Regenerative Cures, School of Veterinary Medicine, University of California, Davis, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Black","sequence":"additional","affiliation":[{"name":"Gallant, San Diego, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,9,25]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X231186834"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11259-008-9153-8"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2017.00209"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.246.6.654"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.14850"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.5966\/sctm.2015-0127"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/089875649701400103"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2016.00054"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-020-01623-9"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/sctm.17-0035"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2023.1171922"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-011110-130230"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2009.10.002"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2014.0317"},{"key":"e_1_3_3_16_2","volume-title":"North American Veterinary Regenerative Medicine Conference","author":"Taechangam N","year":"2023","unstructured":"Taechangam N, Williams V, Hughes M, et al. 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