{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:13:13Z","timestamp":1787069593149,"version":"build-2736575974"},"reference-count":29,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T00:00:00Z","timestamp":1759449600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T00:00:00Z","timestamp":1759449600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100020648","name":"Universidade Estadual de Santa Cruz","doi-asserted-by":"publisher","award":["073.6762.2024.0001739-06"],"award-info":[{"award-number":["073.6762.2024.0001739-06"]}],"id":[{"id":"10.13039\/501100020648","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to evaluate the effects of combined grapiprant and tapentadol on intraoperative physiological parameters, the occurrence of adverse events and postoperative analgesic efficacy in cats undergoing elective ovariohysterectomy, using two multidimensional pain scales.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 60 mixed-breed female cats were enrolled in a randomized, prospective, blinded study. The animals were evenly distributed into four groups (n\u2009=\u200915 per group). In total, 51 animals completed the study; the control group received placebo (CON; n\u2009=\u200911), while the grapiprant group (GRA; n\u2009=\u200913) received grapiprant (3.8\u2009\u00b1\u20090.5\u2009mg\/kg), the tapentadol group (TAP; n\u2009=\u200914) received tapentadol (5.3\u2009\u00b1\u20091.2\u2009mg\/kg) and the grapiprant-tapentadol group (GT; n\u2009=\u200913) received a combination of grapiprant (4.2\u2009\u00b1\u20090.5\u2009mg\/kg PO) and tapentadol (5\u2009\u00b1\u20090.6\u2009mg\/kg PO) 1 hour before initiation of the standardized anesthesia protocol and surgical procedure. Physiological parameters were monitored during surgery, and postoperative pain was assessed for 6\u2009h after extubation using the Short Form of the UNESP-Botucatu Feline Pain Score (UFESP-SF) and the Feline Grimace Scale (FGS), administered by two blinded evaluators.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      No adverse effects or statistically significant differences in physiological parameters were observed between groups. The assessment of pain scores showed good reliability, with intraclass correlation coefficient values of 0.89 for the FGS and 0.91 for the UFESP-SF, supporting inter-rater agreement for both instruments. At 3\u2009h postoperatively, FGS scores differed significantly between the CON and GT groups (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.0363). Rescue analgesia requirements also varied among groups (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.0110): the GT group required rescue at 3\u2009h compared with 1\u2009h in the CON group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.0007) and 2\u2009h in the GRA group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.0058).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and relevance<\/jats:title>\n                    <jats:p>The results of this study showed that the analgesic effect of the grapiprant-tapentadol combination lasted up to 3\u2009h in the postoperative period, which was longer than the 2\u2009h of grapiprant and tapentadol alone, without compromising intraoperative physiological stability.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1098612x251387509","type":"journal-article","created":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T03:50:41Z","timestamp":1759549841000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy of combined grapiprant and tapentadol for analgesia in cats undergoing elective ovariohysterectomy"],"prefix":"10.1177","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-0192-4030","authenticated-orcid":false,"given":"Eduardo Alcides","family":"Alegre","sequence":"first","affiliation":[{"name":"Department of Agricultural and Environmental Sciences, Santa Cruz State University, Ilh\u00e9us, Bahia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5139-5917","authenticated-orcid":false,"given":"Beatriz de Jesus","family":"Lima","sequence":"additional","affiliation":[{"name":"Department of Agricultural and Environmental Sciences, Santa Cruz State University, Ilh\u00e9us, Bahia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7044-5695","authenticated-orcid":false,"given":"Bruna","family":"Vieira","sequence":"additional","affiliation":[{"name":"Department of Agricultural and Environmental Sciences, Santa Cruz State University, Ilh\u00e9us, Bahia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0915-4126","authenticated-orcid":false,"given":"Lara","family":"Almeida Barbosa","sequence":"additional","affiliation":[{"name":"Department of Agricultural and Environmental Sciences, Santa Cruz State University, Ilh\u00e9us, Bahia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1lvaro Jos\u00e9","family":"Ch\u00e1vez Silva","sequence":"additional","affiliation":[{"name":"Department of Agricultural and Environmental Sciences, Santa Cruz State University, Ilh\u00e9us, Bahia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Luiza Santos","family":"Pires","sequence":"additional","affiliation":[{"name":"Department of Agricultural and Environmental Sciences, Santa Cruz State University, Ilh\u00e9us, Bahia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3544-1757","authenticated-orcid":false,"given":"Raquel Vieira","family":"Niella","sequence":"additional","affiliation":[{"name":"Department of Agricultural and Environmental Sciences, Santa Cruz State University, Ilh\u00e9us, Bahia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0795-5320","authenticated-orcid":false,"given":"M\u00e1rio S\u00e9rgio Lima de","family":"Lavor","sequence":"additional","affiliation":[{"name":"Department of Agricultural and Environmental Sciences, Santa Cruz State University, Ilh\u00e9us, Bahia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,10,3]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X211066268"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2013.05.002"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2020.11.014"},{"key":"e_1_3_3_5_2","first-page":"6","article-title":"Survey of pain knowledge and analgesia in dogs and cats by Colombian veterinarians.","author":"Morales-Vallecilla C","year":"2019","unstructured":"Morales-Vallecilla C, Ram\u00edrez N, Villar D, et al. Survey of pain knowledge and analgesia in dogs and cats by Colombian veterinarians. Vet Sci 2019; 6. DOI: 10.3390\/vetsci6010006.","journal-title":"Vet Sci"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/vaa.12104"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.13948"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvp.12983"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.77.7.688"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.22.08.0353"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X241230941"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.5455\/javar.2021.h529"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaa.2016.05.001"},{"key":"e_1_3_3_14_2","first-page":"72","article-title":"Tapentadol: what every doctor needs to know about this new drug.","volume":"1","author":"Mosele BDM","year":"2018","unstructured":"Mosele BDM, Almeida DBD, Hess VB. Tapentadol: what every doctor needs to know about this new drug. Br J Pain 2018; 1: 72\u201376.","journal-title":"Br J Pain"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X221128763"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvp.13399"},{"key":"e_1_3_3_17_2","first-page":"603","article-title":"Description and validation of a new descriptive and multiparametric numeric rating scale to assess sedation in cats.","volume":"63","author":"Rutherford A-A","year":"2022","unstructured":"Rutherford A-A, Sanchez A, Monteith G, et al. Description and validation of a new descriptive and multiparametric numeric rating scale to assess sedation in cats. Can Vet J 2022; 63: 603\u2013608.","journal-title":"Can Vet J"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-55693-8"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.13134"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.7602\/jmis.2023.26.1.9"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.21373"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X221097935"},{"key":"e_1_3_3_23_2","unstructured":"Gasparotto JC. Grapiprant e dipirona na analgesia p\u00f3s-operat\u00f3ria de gatas submetidas a ovariohisterectomia eletiva. Master\u2019s thesis Universidade Federal de Santa Maria http:\/\/repositorio.ufsm.br\/handle\/1\/24295 (2022 accessed 4 April 2025)."},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.80.11.1001"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2012.11.005"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/vaa.12140"},{"key":"e_1_3_3_27_2","first-page":"289","article-title":"Effectiveness of tapentadol hydrochloride for treatment of orthopedic pain in dogs: a pilot study.","volume":"61","author":"Kieves NR","year":"2020","unstructured":"Kieves NR, Howard J, Lerche P, et al. Effectiveness of tapentadol hydrochloride for treatment of orthopedic pain in dogs: a pilot study. Can Vet J 2020; 61: 289\u2013293.","journal-title":"Can Vet J"},{"key":"e_1_3_3_28_2","first-page":"141","article-title":"Plasma concentrations of tapentadol and clinical evaluations of a combination of tapentadol plus sevoflurane for surgical anaesthesia and analgesia in rabbits (Oryctolagus cuniculus) undergoing orchiectomy.","volume":"68","author":"Giorgi M","year":"2013","unstructured":"Giorgi M, Mills PC, Tayari H, et al. Plasma concentrations of tapentadol and clinical evaluations of a combination of tapentadol plus sevoflurane for surgical anaesthesia and analgesia in rabbits (Oryctolagus cuniculus) undergoing orchiectomy. Isr J Vet Med 2013; 68: 141\u2013148.","journal-title":"Isr J Vet Med"},{"key":"e_1_3_3_29_2","article-title":"Calibrating effect-size for studies of pain treatment.","volume":"1","author":"Bogduk N.","year":"2022","unstructured":"Bogduk N. Calibrating effect-size for studies of pain treatment. Interv Pain Med 2022; 1 . DOI: 10.1016\/j.inpm.2022.100123.","journal-title":"Interv Pain Med"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2011.07.002"}],"container-title":["Journal of Feline Medicine and Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1098612X251387509","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1098612X251387509","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1098612X251387509","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T06:16:20Z","timestamp":1784096180000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1098612X251387509"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,3]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1177\/1098612X251387509"],"URL":"https:\/\/doi.org\/10.1177\/1098612x251387509","relation":{},"ISSN":["1098-612X","1532-2750"],"issn-type":[{"value":"1098-612X","type":"print"},{"value":"1532-2750","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,3]]},"article-number":"1098612X251387509"}}