{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T05:04:10Z","timestamp":1784091850665,"version":"3.55.0"},"reference-count":37,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100010705","name":"british small animal veterinary association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010705","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of the present study was to report changes in serum creatinine and symmetric dimethylarginine (SDMA) concentrations after treatment of feline hyperthyroidism with anti thyroid medications and to compare these biomarkers at baseline between cats that were and were not azotaemic after treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective study, hyperthyroid cats that were euthyroid (total thyroxine [TT4] concentration 7\u201340\u2009nmol\/l) at 1 month (T1) and\/or 2\u20139 months (T2) after treatment were identified and grouped by renal status defined by serum creatinine concentrations. Comparisons were made using non-parametric statistics and the correlations assessed using Spearman\u2019s correlation coefficient. Data are presented as median (minimum\u2013maximum).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 19 hyperthyroid cats were included. At baseline, TT4 was negatively correlated with serum concentration of creatinine (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      <jats:sub>s<\/jats:sub>\n                      \u2009=\u2009\u22120.73;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001) but not SDMA (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      <jats:sub>s<\/jats:sub>\n                      \u2009=\u2009\u22120.42;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.074). Serum creatinine concentrations increased significantly at T1 and T2 (137\u2009\u03bcmol\/l [range 97\u2013241] and 162\u2009\u03bcmol\/l [range 76\u2013251]) compared with baseline (117\u2009\u03bcmol\/l [range 62\u2013216];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.003 and\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001, respectively), whereas serum SDMA did not change significantly at T1 but did increase by T2 (11\u2009\u03bcg\/dl [range 8\u201329] and 13\u2009\u03bcg\/dl [range 9\u201324], respectively) compared with baseline (12\u2009\u03bcg\/dl [range 7\u201321];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.548 and\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.039, respectively). There was no significant difference in baseline serum SDMA between cats that were azotaemic after treatment and those that remained non-azotaemic (12\u2009\u03bcg\/dl [range 7\u201321], n\u2009=\u200913 vs 13\u2009\u03bcg\/dl [range 11\u201319], n\u2009=\u20096;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.42).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and relevance<\/jats:title>\n                    <jats:p>Serum SDMA concentrations are not helpful in predicting post-treatment azotaemia in initially non-azotaemic hyperthyroid cats treated with antithyroid medications and might be influenced by factors other than glomerular filtration rate in hyperthyroidism.<\/jats:p>\n                  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UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9775-8285","authenticated-orcid":false,"given":"Timothy L","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, University of Cambridge, Cambridge, 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