{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T21:21:04Z","timestamp":1784323264673,"version":"3.55.0"},"reference-count":35,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K05995"],"award-info":[{"award-number":["22K05995"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25K09425"],"award-info":[{"award-number":["25K09425"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of the study was to investigate the effects of high-dose (HD) carvedilol treatment in client-owned cats with stage B1 obstructive hypertrophic cardiomyopathy (oHCM) where a standard dose (SD) had failed to adequately alleviate left ventricular outflow tract (LVOT) obstruction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective, interventional study was conducted in which cats underwent echocardiography, including evaluation of myocardial strain using speckle-tracking echocardiography. Myocardial injury was quantified using a cardiac troponin I (cTnI) assay. Echocardiographic variables and the cTnI level were compared before treatment and after SD and HD carvedilol treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      LVOT velocity (LVOTV) decreased after SD compared with before treatment in all cats, but remained above 2.5\u2009m\/s after SD (before treatment 4.9\u2009m\/s [interquartile range [IQR] 4.3\u20135.0]; SD 4.3\u2009m\/s [IQR 3.9\u20134.7]), whereas HD decreased LVOTV to below 2.5\u2009m\/s in 10\/11 cats (1.6\u2009m\/s [IQR 1.5\u20132.0]). Longitudinal strain was improved after SD and HD compared with before treatment (endocardial layer: before treatment 12.1% [IQR 9.6\u201315.8]; SD 20.0% [IQR 15.9\u201321.7]; HD 18.9% [IQR 12.9\u201322.8];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.003 and\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.006, respectively; epicardial layer: before treatment 9.4% [IQR 7.0\u201310.7]; SD 11.6% [IQR 10.0\u201312.7]; HD 12.5% [IQR 10.0\u201313.3];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.013 and\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.001, respectively). Circumferential strain demonstrated no changes. The cTnI level decreased after SD and HD compared with before treatment, and after HD compared with SD (before treatment 0.334\u2009ng\/ml [IQR 0.117\u20130.931]; SD 0.192\u2009ng\/ml [IQR 0.111\u20130.377]; HD 0.018\u2009ng\/ml [IQR 0.009\u20130.161];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.043,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.043 and\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.043, respectively). No cats experienced adverse effects such as bradycardia or hypotension.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and relevance<\/jats:title>\n                    <jats:p>HD improved LVOTV, myocardial function and cTnI level without adverse effects in cats with stage B1 oHCM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1098612x261433060","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T10:23:40Z","timestamp":1773224620000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy of high-dose carvedilol treatment for cats with stage B1 obstructive hypertrophic cardiomyopathy"],"prefix":"10.1177","volume":"28","author":[{"given":"Shuji","family":"Satomi","sequence":"first","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, Department of Veterinary Science, Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University, Musashino-shi, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9451-5854","authenticated-orcid":false,"given":"Ryohei","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, Department of Veterinary Science, Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University, Musashino-shi, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6293-7320","authenticated-orcid":false,"given":"Yunosuke","family":"Yuchi","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, Department of Veterinary Science, Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University, Musashino-shi, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruka","family":"Kanno","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, Department of Veterinary Science, Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University, Musashino-shi, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Inoue","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, Department of Veterinary Science, Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University, Musashino-shi, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Teshima","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, Department of Veterinary Science, Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University, Musashino-shi, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotaka","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, Department of Veterinary Science, Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University, Musashino-shi, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,3,6]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X211020162"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1760-2734(06)70051-0"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/481245"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15122"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.11.069"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2019.06.004"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/000331978503601101"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2024.09.002"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001250"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15745"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2011.0754.x"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.19-0670"},{"key":"e_1_3_3_14_2","article-title":"Prevalence and prognosis of atenolol-responsive systolic anterior motion of the septal mitral valve leaflet in young cats with severe dynamic left ventricular outflow tract obstruction.","volume":"12","author":"Kortas M","year":"2022","unstructured":"Kortas M, Szatm\u00e1ri V. 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