{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T09:04:06Z","timestamp":1784538246319,"version":"3.55.0"},"reference-count":30,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The underlying aetiology of feline idiopathic vestibular syndrome (IVS) remains unclear. In humans, specific MRI sequences are used to demonstrate differences in endolymph composition between unaffected and affected inner ears. A previous study in dogs with IVS reported that in 93% of cases, the clinically affected side exhibited a lower degree of fluid-attenuated inversion recovery (FLAIR) suppression, which may indicate altered endolymph composition, potentially due to increased protein concentration. The objective of this study was to determine whether similar changes can be observed in cats with IVS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Medical records from three referral hospitals were reviewed. Cats were included if they had a diagnosis of IVS, clear lateralisation of clinical signs and had undergone MRI of the brain. Regions of interest (ROIs) were manually outlined to define the inner ear on T2-weighted and FLAIR images. The FLAIR suppression ratio for each ear was assessed by calculating the average signal intensity across both imaging sequences. Any unilateral reduction in suppression was compared with the direction of clinical signs. ROI size was also measured to evaluate potential swelling or collapse of inner ear structures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 25 cats met the inclusion criteria. No correlation was found between the clinically affected side and the degree of FLAIR suppression. In 11\/25 cats, the identified abnormal side did not correspond to the lateralisation of clinical signs, whereas in 14\/25 cats it did. ROI measurements likewise showed no consistent association with the clinically affected side.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and relevance<\/jats:title>\n                    <jats:p>In the present cohort, these findings indicate that cats with IVS did not show a consistent association between clinical lateralisation and MRI-detectable endolymph changes, supporting the possibility of a different underlying pathophysiology compared with dogs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1098612x261445137","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T04:06:36Z","timestamp":1776225996000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Lack of association between inner ear FLAIR suppression on MRI and laterality of clinical signs in feline idiopathic vestibular syndrome"],"prefix":"10.1177","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7696-2099","authenticated-orcid":false,"given":"Magdalena","family":"Putzer","sequence":"first","affiliation":[{"name":"Department of Small Animal Medicine and Surgery, University of Veterinary Medicine Hannover, Hanover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2505-2152","authenticated-orcid":false,"given":"Steven","family":"De Decker","sequence":"additional","affiliation":[{"name":"Queen Mother Hospital for Animals, Clinical Science and Services, Royal Veterinary College London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3570-2542","authenticated-orcid":false,"given":"Rodrigo","family":"Gutierrez Quintana","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9487-1365","authenticated-orcid":false,"given":"Anna M","family":"Mosel","sequence":"additional","affiliation":[{"name":"Department of Small Animal Medicine and Surgery, University of Veterinary Medicine Hannover, Hanover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7312-638X","authenticated-orcid":false,"given":"Holger A","family":"Volk","sequence":"additional","affiliation":[{"name":"Department of Small Animal Medicine and Surgery, University of Veterinary Medicine Hannover, Hanover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,4,14]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2012.08.006"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2009.09.007"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2009.10.029"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15869"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1098-612X(02)00124-9"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(97)50134-3"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X20970869"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2023.1263976"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016488809125107"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1098-612X(99)90064-5"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/vru.12605"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2021.105748"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/vetr.5324"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X231168001"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2010.04.002"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/vru.12876"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.27793"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000000366"},{"key":"e_1_3_2_20_2","first-page":"300","article-title":"Vestibular disorders.","volume":"117","author":"Strupp M","year":"2020","unstructured":"Strupp M, Dlugaiczyk J, Ertl-Wagner BB, et al. 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