{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T12:05:08Z","timestamp":1784030708307,"version":"3.55.0"},"reference-count":19,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Purina Petcare Research"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of the present study was to identify differences in fecal analytes (ie, microbiota, fatty acids [FAs]) in cats with exocrine pancreatic insufficiency (EPI) compared with healthy controls, and describe clinical signs at baseline and short-term follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross-sectional, observational study was conducted of 55 client-owned cats with EPI and 37 healthy client-owned blood donor control cats. Eligible cases had a feline trypsin-like immunoreactivity (fTLI) consistent with EPI. Fecal samples were analyzed for fecal microbiota dysbiosis index (DI) and FAs. Serum and fecal analytes from controls were compared with EPI cats using parametric and non-parametric methods including general linear models to adjust for potential confounding by signalment differences. Clinical signs were described for cats with EPI at enrollment and for one short-term follow-up time point.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fecal DI and FAs were abnormal in EPI cases compared with controls. Cats with EPI had a higher median DI (1.5 [range \u22122.6 to 3.8]), total FAs (74.1\u2009\u00b5g\/g [range 4.7\u2013162]), arachidonic acid (2.54\u2009\u00b5g\/g [range 0.03\u201317.0]) and nervonic acid (0.37\u2009\u00b5g\/g [range 0.02\u20131.5]) than controls (\u20133 [range \u22124.4 to \u22120.6], 19.7\u2009\u00b5g\/g [range 9.4\u201375.2], 0.57\u2009\u00b5g\/g [range 0.32\u20131.51] and 0.17\u2009\u00b5g\/g [range 0.09\u20130.54], respectively), and a lower median\n                      <jats:italic toggle=\"yes\">Peptacetobacter hiranonis<\/jats:italic>\n                      (4.8 log DNA [range 0.1\u20136.1]) compared with controls (5.9 log DNA [range 3.2\u20136.8]). The most common clinical signs were weight loss and appetite disturbances.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and relevance<\/jats:title>\n                    <jats:p>Cats with EPI have alterations in fecal microbiota and FA, and clinical signs in this population of cats were similar to those previously reported.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1098612x261446328","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T04:24:06Z","timestamp":1776399846000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Gastrointestinal microbiota and fecal fatty acids of cats with exocrine pancreatic insufficiency"],"prefix":"10.1177","volume":"28","author":[{"given":"Andrea","family":"Huther","sequence":"first","affiliation":[{"name":"Department of Small Animal Clinical Sciences, College of Veterinary Medicine &amp; Biomedical Sciences, Texas A&amp;M University, College Station, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2961-2452","authenticated-orcid":false,"given":"Emily N","family":"Gould","sequence":"additional","affiliation":[{"name":"Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine &amp; Biomedical Sciences, Texas A&amp;M University, College Station, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chee-Hoon","family":"Chang","sequence":"additional","affiliation":[{"name":"Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine &amp; Biomedical Sciences, Texas A&amp;M University, College Station, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makenzie","family":"Anderson-Kaapa","sequence":"additional","affiliation":[{"name":"Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine &amp; Biomedical Sciences, Texas A&amp;M University, College Station, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey T","family":"Fosgate","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, Lewyt College of Veterinary Medicine, Long Island University, Brookville, NY, USA"},{"name":"Department of Production Animal Studies, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan S","family":"Suchodolski","sequence":"additional","affiliation":[{"name":"Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine &amp; Biomedical Sciences, Texas A&amp;M University, College Station, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,4,16]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.tcam.2012.04.005"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.23.09.0505"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.14560"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anaerobe.2017.02.010"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0224454"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0257856"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2007.11.008"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2001.62.1852"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2000.61.620"},{"key":"e_1_3_3_11_2","first-page":"309","article-title":"Development and analytical validation of a radioimmunoassay for the measurement of feline pancreatic lipase immunoreactivity in serum.","volume":"68","author":"Steiner JM","year":"2004","unstructured":"Steiner JM, Wilson BG, Williams DA. Development and analytical validation of a radioimmunoassay for the measurement of feline pancreatic lipase immunoreactivity in serum. Can J Vet Res 2004; 68: 309\u2013314.","journal-title":"Can J Vet Res"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/vcp.13283"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X221077876"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/ani13172753"},{"key":"e_1_3_3_15_2","article-title":"Dysregulated bile acid homeostasis: unveiling its role in metabolic diseases.","volume":"4","author":"Wang Y","year":"2024","unstructured":"Wang Y, Xu H, Zhou X, et al. Dysregulated bile acid homeostasis: unveiling its role in metabolic diseases. Med Rev (2021) 2024; 4: 262\u2013283.","journal-title":"Med Rev (2021)"},{"key":"e_1_3_3_16_2","article-title":"Effects of metronidazole on the fecal microbiota, fecal metabolites, and serum metabolites of healthy adult cats.","volume":"2","author":"Martini SE","year":"2025","unstructured":"Martini SE, Schmidt T, Huang W, et al. Effects of metronidazole on the fecal microbiota, fecal metabolites, and serum metabolites of healthy adult cats. Pets 2025; 2. DOI: 10.3390\/pets2020019.","journal-title":"Pets"},{"key":"e_1_3_3_17_2","first-page":"425","article-title":"Long chain fatty acids and gene expression in inflammation and immunity.","volume":"16","author":"Calder PC.","year":"2013","unstructured":"Calder PC. Long chain fatty acids and gene expression in inflammation and immunity. Curr Opin Clin Nutr Metab Care 2013; 16: 425\u2013433.","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26094034"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12122764"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.3390\/ani13142313"}],"container-title":["Journal of Feline Medicine and Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1098612X261446328","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1098612X261446328","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1098612X261446328","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T11:29:24Z","timestamp":1784028564000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1098612X261446328"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,16]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1177\/1098612X261446328"],"URL":"https:\/\/doi.org\/10.1177\/1098612x261446328","relation":{},"ISSN":["1098-612X","1532-2750"],"issn-type":[{"value":"1098-612X","type":"print"},{"value":"1532-2750","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,16]]},"article-number":"1098612X261446328"}}