{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T09:05:52Z","timestamp":1783933552821,"version":"3.55.0"},"reference-count":41,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Tarsal tumours are rare, but previous reports suggest a predilection for round cell tumours (RCTs) and soft tissue sarcomas (STSs) in this region. This study aimed to determine the proportion of RCTs among feline tarsal neoplasms, refine classification through histological revision and immunohistochemistry (IHC), assess potential risk factors and evaluate clinical outcomes based on tumour histotypes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective analysis of feline tarsal neoplasms diagnosed between 2010 and 2024 was conducted. Signalment, history, treatment and outcomes were collected for RCTs and STSs. All RCTs underwent histological review and IHC (CD3, CD20, CD79a, MUM-1, CD18, IBA-1, E-CAD). A diagnostic algorithm was applied to support the diagnostic process.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 34 cases were included: 18 RCTs and 16 STSs. In 39% of RCTs, the initial histotype was undetermined. After IHC and application of the diagnostic algorithm, 50% of cases were reclassified: seven plasma cell tumours, four progressive histiocytosis, three lymphomas, two histiocytic sarcomas and two undifferentiated RCTs. Male sex, older age and prior tarsal trauma were significantly associated with RCTs (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.042,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.048 and\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.009, respectively). Clinical signs and metastases at diagnosis were more frequent in RCTs (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.019 and\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.001, respectively). RCT treatment included chemotherapy (n\u2009=\u20097), surgery (n\u2009=\u20095), surgery and chemotherapy (n\u2009=\u20092), prednisolone (n\u2009=\u20091) or none (n\u2009=\u20091); two cases lacked treatment data. All STSs were managed surgically without chemotherapy. Time to progression and median survival were significantly shorter for RCTs compared with STSs (139 vs 854 days; 173 vs not reached, respectively;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and relevance<\/jats:title>\n                    <jats:p>This study confirms that feline tarsal RCTs are a heterogeneous group of tumours with a poor prognosis. Risk factors may include male sex, older age and previous tarsal trauma. A standardised IHC panel combined with a diagnostic algorithm improved histotyping accuracy and should be adopted in clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1098612x261446336","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T09:24:48Z","timestamp":1776417888000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Feline tarsal tumours: histological spectrum, risk factors and prognostic insights"],"prefix":"10.1177","volume":"28","author":[{"given":"Gianmarco","family":"Lollo","sequence":"first","affiliation":[{"name":"Department of Veterinary Medical Sciences, University of Bologna, Ozzano Emilia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7005-2736","authenticated-orcid":false,"given":"Silvia","family":"Sabattini","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Sciences, University of Bologna, Ozzano Emilia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greta","family":"Foiani","sequence":"additional","affiliation":[{"name":"Istituto Zooprofilattico Sperimentale delle Venezie, Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Vascellari","sequence":"additional","affiliation":[{"name":"Istituto Zooprofilattico Sperimentale delle Venezie, Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Rigillo","sequence":"additional","affiliation":[{"name":"I-Vet srl\u2013Veterinary Diagnostic Lab, Flero, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Melchiotti","sequence":"additional","affiliation":[{"name":"Istituto Zooprofilattico Sperimentale delle Venezie, Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Marconato","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Sciences, University of Bologna, Ozzano Emilia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,4,17]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.244.12.1429"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/03009858211048621"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X11429226"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1354\/vp.43-6-1014"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12142"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5810.2004.00032.x"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.1989.195.11.1593"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X20905035"},{"key":"e_1_3_2_10_2","first-page":"404","volume-title":"Withrow & MacEwen\u2019s small animal clinical oncology","author":"Liptak JM","year":"2020","unstructured":"Liptak JM, Christensen NI. Soft tissue sarcomas. In: Vail DM, Thamm DH, Liptak JM (eds). Withrow & MacEwen\u2019s small animal clinical oncology. 6th ed. Elsevier, 2020, pp 404\u2013431.","edition":"6"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/2055116919875532"},{"key":"e_1_3_2_12_2","first-page":"757","article-title":"Limb-shortening limb salvage (LSLS) in a cat with metatarsal osteosarcoma.","volume":"60","author":"Boylan MT","year":"2019","unstructured":"Boylan MT, Boston SE, Townsend S, et al. Limb-shortening limb salvage (LSLS) in a cat with metatarsal osteosarcoma. Can Vet J 2019; 60: 757\u2013761.","journal-title":"Can Vet J"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.5326\/JAAHA-MS-6349"},{"key":"e_1_3_2_14_2","article-title":"Outcome of appendicular or scapular osteosarcoma treated by limb amputation in cats: 67 cases (1997\u20132018).","volume":"260","author":"Nakano Y","year":"2021","unstructured":"Nakano Y, Kagawa Y, Shimoyama Y, et al. Outcome of appendicular or scapular osteosarcoma treated by limb amputation in cats: 67 cases (1997\u20132018). 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