{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T09:31:27Z","timestamp":1794562287129,"version":"4.9.1"},"reference-count":24,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Serial measurement of serum feline pancreatic lipase immunoreactivity (fPLI) and trypsin-like immunoreactivity (fTLI) concentrations in cats with chronic enteropathy (CE) has not been previously reported. The aim of the current observational study was to serially evaluate serum fPLI and fTLI concentrations in cats with different forms of CE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 60 cats with CE were included, diagnosed either with immunosuppressive-responsive enteropathy (IRE; n\u2009=\u200922), food-responsive enteropathy (FRE; n\u2009=\u20097) or low-grade intestinal T-cell lymphoma (LGITL; n\u2009=\u200932, one diagnosed previously as FRE progressed to lymphoma). Serum fPLI and fTLI concentrations were measured in 252 and 245 serum samples, respectively, from 60 cats with CE at initial presentation and during re-examination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Serum fPLI concentrations indicative of pancreatitis were found in 3\/60 cats (one with IRE and two with LGITL) at initial presentation and in an additional 8\/60 cats (four with IRE and four with LGITL) during treatment (24\/252 serum samples). Serum fTLI concentrations indicative of exocrine pancreatic insufficiency were found in 2\/60 cats (both with IRE) at initial presentation and during re-examination (n\u2009=\u20093\/245). None of the cats with FRE had fPLI concentrations above or fTLI concentrations below the respective reference intervals (RIs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and relevance<\/jats:title>\n                    <jats:p>Serum fPLI concentrations may fluctuate during treatment in a subset of cats with IRE or LGITL and, in some cats, are indicative of pancreatitis. Serum fTLI concentrations may vary within and outside the RI in a relatively small proportion of cats with IRE. The long-term clinical importance of these findings requires further study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1098612x261472195","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T07:12:13Z","timestamp":1784704333000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Serial measurement of serum pancreatic lipase immunoreactivity and trypsin-like immunoreactivity concentrations in cats with chronic enteropathy"],"prefix":"10.1177","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7505-7816","authenticated-orcid":false,"given":"Dimitra A","family":"Karra","sequence":"first","affiliation":[{"name":"Clinic of Medicine, Faculty of Veterinary Science, University of Thessaly, Karditsa, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1070-6758","authenticated-orcid":false,"given":"Katerina T","family":"Moraiti","sequence":"additional","affiliation":[{"name":"Clinic of Medicine, Faculty of Veterinary Science, University of Thessaly, Karditsa, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan A","family":"Lidbury","sequence":"additional","affiliation":[{"name":"Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&amp;M University, College Station, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3336-2086","authenticated-orcid":false,"given":"Joerg M","family":"Steiner","sequence":"additional","affiliation":[{"name":"Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&amp;M University, College Station, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3471-4816","authenticated-orcid":false,"given":"Shelley J","family":"Newman","sequence":"additional","affiliation":[{"name":"Newman Specialty VetPath, Hicksville, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2261-281X","authenticated-orcid":false,"given":"Paula R","family":"Giaretta","sequence":"additional","affiliation":[{"name":"Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&amp;M University, College Station, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3170-9349","authenticated-orcid":false,"given":"Jo\u00e3o Pedro","family":"Cavasin","sequence":"additional","affiliation":[{"name":"Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&amp;M University, College Station, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9508-0271","authenticated-orcid":false,"given":"Panagiotis G","family":"Xenoulis","sequence":"additional","affiliation":[{"name":"Clinic of Medicine, Faculty of Veterinary Science, University of Thessaly, Karditsa, Greece"},{"name":"Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&amp;M University, College Station, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,22]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.13332"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.1992.201.10.1603"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2009.0443.x"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X12451548"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/0300985811404712"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X12439266"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1354\/vp.44-1-39"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.16053"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2009.04.004"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.14560"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X20965831"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.14356"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2003.223.469"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.12313"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2020.06.008"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X251367621"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2010.0549.x"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2008.01.001"},{"key":"e_1_3_2_20_2","first-page":"309","article-title":"Development and analytical validation of a radioimmunoassay for the measurement of feline pancreatic lipase immunoreactivity in serum.","volume":"68","author":"Steiner JM","year":"2004","unstructured":"Steiner JM, Wilson BG, Williams DA. Development and analytical validation of a radioimmunoassay for the measurement of feline pancreatic lipase immunoreactivity in serum. Can J Vet Res 2004; 68: 309\u2013314.","journal-title":"Can J Vet Res"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/vcp.13283"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.70163"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2008.00693.x"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2010.00973.x"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.5114\/pjp.2024.141222"}],"container-title":["Journal of Feline Medicine and Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1098612X261472195","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1098612X261472195","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1098612X261472195","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T09:02:25Z","timestamp":1794560545000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1098612X261472195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,22]]},"references-count":24,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1177\/1098612X261472195"],"URL":"https:\/\/doi.org\/10.1177\/1098612x261472195","relation":{},"ISSN":["1098-612X","1532-2750"],"issn-type":[{"value":"1098-612X","type":"print"},{"value":"1532-2750","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,22]]},"article-number":"1098612X261472195"}}