{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T06:28:53Z","timestamp":1793773733401,"version":"4.6.1"},"reference-count":54,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Piano di Sostegno alla Ricerca 2023 Linea 2, University of Milan, Italy","id":[{"id":"https:\/\/ror.org\/00wjc7c48","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>The aim of the present study was to determine the prevalence of increased serum high-sensitivity cardiac troponin I (hs-cTnI) concentrations in cats with acute blunt trauma and assess associations with trauma severity, clinicopathological variables, echocardiographic findings, and short-term outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A total of 39 cats presenting within 48\u2009h of blunt trauma were prospectively enrolled. All cats underwent physical examination, Animal Trauma Triage scoring, thoracic radiography, electrocardiography, echocardiography, complete blood count, serum biochemistry, N-terminal pro B-type natriuretic peptide testing, and hs-cTnI measurement. Associations between hs-cTnI concentrations and clinical, laboratory, echocardiographic, and outcome variables were assessed. Receiver operating characteristic (ROC) analysis was performed as an exploratory assessment of prognostic performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Increased hs-cTnI concentrations were detected in 34\/39 (87%) cats (95% confidence interval 72\u201396). A significant ordinal association was identified between trauma severity and hs-cTnI class (linear-by-linear association,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.036), although the overall Fisher\u2013Freeman\u2013Halton test was not significant (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.088). Hs-cTnI concentrations correlated positively with urea, creatinine, neutrophil count, alanine aminotransferase, neutrophil:lymphocyte ratio, blood glucose, end-diastolic interventricular septal, and posterior wall thicknesses, and negatively with end-diastolic left ventricular internal diameter. Increased left ventricular wall thickness was identified in 10\/39 cats and was associated with higher hs-cTnI concentrations (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.033). No traumatic cardiac rupture, pericardial effusion, or pleural effusion were observed. Electrocardiographic abnormalities were detected in 6\/39 cats and were not associated with hs-cTnI concentrations. Seven cats (18%) died during hospitalization. Increased urea concentration, white blood cell count, and neutrophil count were associated with non-survival. ROC analyses were considered exploratory because of the limited number of outcome events.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and relevance:<\/jats:title>\n                    <jats:p>Increased hs-cTnI concentrations were common in cats with acute blunt trauma and were associated with leukocyte variables, renal function markers, and subtle echocardiographic abnormalities. These findings suggest that hs-cTnI may reflect a multifactorial biological response involving myocardial stress or injury, systemic disease severity, altered renal handling, and possible underlying subclinical cardiac disease. Further studies are needed to clarify the relative contribution and clinical significance of these mechanisms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1098612x261480992","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T12:27:30Z","timestamp":1786710450000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Myocardial injury in cats with acute blunt trauma: Prevalence and prognostic implications"],"prefix":"10.1177","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-8582-3194","authenticated-orcid":false,"given":"Greta","family":"Dossi","sequence":"first","affiliation":[{"name":"Department of Veterinary Medicine and Animal Sciences, University of Milan, Lodi, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5023-0782","authenticated-orcid":false,"given":"Liliana","family":"Carnevale","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Animal Sciences, University of Milan, Lodi, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Mismetti","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Animal Sciences, University of Milan, Lodi, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0712-6672","authenticated-orcid":false,"given":"Vitaliano","family":"Borromeo","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Animal Sciences, University of Milan, Lodi, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1362-001X","authenticated-orcid":false,"given":"Paola","family":"Pocar","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Animal Sciences, University of Milan, Lodi, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6014-4378","authenticated-orcid":false,"given":"Chiara","family":"Locatelli","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Animal Sciences, University of Milan, Lodi, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,14]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","unstructured":"O\u2019Neill DG Church DB McGreevy PD et al. 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