{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T08:37:57Z","timestamp":1793176677178,"version":"4.5.0"},"reference-count":15,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"College of Veterinary Medicine Clinical Research Grant and Summer Scholar Program"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>The aim of the study was to determine whether post admission oral gabapentin improves stress indices and handling tolerance in hospitalized cats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In this double-blind, randomized, placebo-controlled, parallel-design trial, healthy client-owned cats were enrolled. After the initial examination, cats received a 100\u2009mg gabapentin or placebo capsule. At 90\u2009min, a second examination, venipuncture, and brief dorsal positioning were performed. Five stress behaviors (struggling, vocalization, repelling, hypersalivation, mouth breathing), compliance, and enclosure activity score (1, sedate; 5, very active) were recorded; blood glucose, lactate, serum cortisol, and lymphocyte count were measured. Serum gabapentin concentrations were obtained 90\u2009min after the capsule.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 30 cats (15 cats\/group) were included in analysis. In the 15 cats who received gabapentin, the median gabapentin dose was 21.7\u2009mg\/kg (range 14.3\u201328.1), yielding a median serum concentration of 16.4\u2009\u00b5g\/ml (range 1.3\u201324.5). Most gabapentin-treated cats exhibited fewer stress behaviors (n\u2009=\u200913\/15, 87%) and better compliance for handling during examination (n\u2009=\u200911\/15, 73%) at 90\u2009min post-capsule compared with 3\/15 (20%) and 4\/15 (27%), respectively, in placebo cats. Between-group differences were not detected for behavioral or compliance scores during venipuncture or dorsal positioning. Enclosure activity scores in the gabapentin group decreased from median 3 at baseline to 2 from 90\u2013360\u2009min post-dose (120, 240, and 300\u2009min;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.05, respectively), consistent with mild sedation. Blood lactate and cortisol concentrations were lower in the gabapentin group than the placebo group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.002 and\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.04, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and relevance:<\/jats:title>\n                    <jats:p>A 100\u2009mg oral dose of gabapentin provides modest improvement in stress behaviors during examination and favorably alters select physiologic stress markers within 90\u2009min of administration, with sustained reductions in kennel activity. Findings support incorporating gabapentin within a multimodal, low-stress approach for cats presenting without preappointment medication, while maintaining contingency plans for additional sedation as needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1098612x261484767","type":"journal-article","created":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T04:22:20Z","timestamp":1787977340000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of oral gabapentin administered in-hospital on behavioral stress, compliance, and physiologic stress markers: A randomized, double-blind, placebo-controlled trial"],"prefix":"10.1177","volume":"28","author":[{"given":"Camille","family":"Canosa","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, Oregon State University, Gary R. Carlson, MD, College of Veterinary Medicine, Corvallis, OR, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1512-9603","authenticated-orcid":false,"given":"Stacie C.","family":"Summers","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Oregon State University, Gary R. Carlson, MD, College of Veterinary Medicine, Corvallis, OR, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,28]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","unstructured":"Rodan I Dowgray N Carney HC et al. 2022 AAFP\/ISFM cat friendly veterinary interaction guidelines: Approach and handling techniques. J Feline Med Surg 2022; 24: 1093\u20131132. https:\/\/doi.org\/10.1177\/1098612x221128760","DOI":"10.1177\/1098612X221128760"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","unstructured":"Taylor S St Denis K Collins S et al. 2022 ISFM\/AAFP cat friendly veterinary environment guidelines. J Feline Med Surg 2022; 24: 1133\u20131163. https:\/\/doi.org\/10.1177\/1098612x221128763","DOI":"10.1177\/1098612X221128763"},{"key":"e_1_3_2_4_2","first-page":"952","article-title":"A review of pre-appointment medications to reduce fear and anxiety in dogs and cats at veterinary visits.","volume":"62","author":"Erickson A","year":"2021","unstructured":"Erickson A, Harbin K, MacPherson J, et al. A review of pre-appointment medications to reduce fear and anxiety in dogs and cats at veterinary visits. Can Vet J 2021; 62: 952\u2013960.","journal-title":"Can Vet J"},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","unstructured":"van Haaften KA Forsythe LRE Stelow EA et al. Effects of a single preappointment dose of gabapentin on signs of stress in cats during transportation and veterinary examination. J Am Vet Med Assoc 2017; 251: 1175\u20131181. https:\/\/doi.org\/10.2460\/javma.251.10.1175","DOI":"10.2460\/javma.251.10.1175"},{"key":"e_1_3_2_6_2","doi-asserted-by":"crossref","unstructured":"Kruszka M Graff E Medam T et al. Clinical evaluation of the effects of a single oral dose of gabapentin on fear-based aggressive behaviors in cats during veterinary examinations. J Am Vet Med Assoc 2021; 259: 1285\u20131291. https:\/\/doi.org\/10.2460\/javma.20.06.0307","DOI":"10.2460\/javma.20.06.0307"},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","unstructured":"Eagan BH van Haaften K Protopopova A. Daily gabapentin improved behavior modification progress and decreased stress in shelter cats from hoarding environments in a double-blind randomized placebo-controlled clinical trial. 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