{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T10:35:06Z","timestamp":1792665306946,"version":"4.5.0"},"reference-count":65,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2009,12,22]],"date-time":"2009-12-22T00:00:00Z","timestamp":1261440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological Research For Nursing"],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:p>Many chronic wounds fail to heal with conventional therapy, resulting in disability and impaired quality of life. New technologies using recombinant growth factors, autologous growth factors, or bioengineered skin\u2014tissue substitutes have been shown to be effective, but these treatments are costly. An effective, low-cost treatment to improve healing of chronic wounds is needed. The molecular environment of chronic wounds, like many other chronic inflammatory diseases, contains abnormally high levels of proinflammatory cytokines (tumor necrosis factor [TNF]-\u03b1 and interleukin [IL]-1\u03b2]) and matrix metalloproteinases (MMPs), which impair normal wound healing. In animal models and clinical studies of ulcerative diseases, doxycycline, an inexpensive and Food and Drug Administration (FDA)-approved antibiotic, appears to inhibit members of the MMP superfamily like MMPs and TNF-\u03b1-converting enzyme (TACE). This article provides an overview of the roles of MMPs and intrinsic tissue inhibitors of metalloproteinases (TIMPs) in wound healing and the damaging effects of chronically elevated levels of MMPSs in chronic wounds. It also explores the use of topical doxycycline, a synthetic MMP inhibitor (MMPI), to enhance healing of chronic wounds.<\/jats:p>","DOI":"10.1177\/1099800409346333","type":"journal-article","created":{"date-parts":[[2009,12,23]],"date-time":"2009-12-23T20:50:11Z","timestamp":1261601411000},"page":"336-344","source":"Crossref","is-referenced-by-count":103,"title":["The Role of Doxycycline as a Matrix Metalloproteinase Inhibitor for the Treatment of Chronic Wounds"],"prefix":"10.1177","volume":"11","author":[{"given":"Joyce","family":"Stechmiller","sequence":"first","affiliation":[{"name":"College of Nursing, University of Florida, Gainesville,\rFlorida,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Cowan","sequence":"additional","affiliation":[{"name":"North Florida\/South Georgia Veterans Health Systems,\rUniversity of Florida, Gainesville, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Schultz","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University\rof Florida, Gainesville, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2009,12,22]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1994.tb04974.x"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.7547\/87507315-92-1-12"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.136.1.1"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199809020-00015"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(96)00525-2"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199606273342607"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1016\/0955-0674(95)80116-2"},{"key":"atypb8","first-page":"1569","volume":"30","author":"Burns, F.R.","year":"1989","journal-title":"Investigative Ophthalmology and Visual Science"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1994.tb01218.x"},{"key":"atypb10","first-page":"315","volume":"15","author":"Chin, G.A.","year":"2003","journal-title":"Wounds"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2001.028002146.x"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1995.tb00120.x"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12499839"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12342990"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1994.tb24776.x"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1997.tb01377.x"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400806"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1021\/bi972120y"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-002-0868-8"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.141.11.1476"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-475X.1996.40404.x"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1097\/01.BCR.0000169887.04973.3A"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.3109\/17453679509157648"},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(91)80895-A"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2008.05.002"},{"key":"atypb26","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(95)48032-3"},{"key":"atypb27","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.31.21491"},{"key":"atypb28","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.1998.5495"},{"key":"atypb29","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-475X.1998.60206.x"},{"key":"atypb30","doi-asserted-by":"publisher","DOI":"10.1016\/S0094-1298(20)32468-8"},{"key":"atypb31","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-475X.1999.00423.x"},{"key":"atypb32","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.7.4281"},{"key":"atypb33","first-page":"742","volume":"17","author":"Perry, H.D.","year":"1985","journal-title":"Annals of Ophthalmology"},{"key":"atypb34","first-page":"18147","volume":"272","author":"Pilcher, B.K.","year":"1997","journal-title":"A common receptor pathway. 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