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The reduction in sex steroids and growth hormones and declines in vitamin D concentration that accompany the aging process are associated with increases in the baseline levels of inflammatory proteins. At the same time, inflammation arising from atherosclerosis and other chronic diseases further contributes to the inflammatory milieu and effects a state of chronic inflammation. This chronic inflammation, or \u2018\u2018inflammaging\u2019\u2019 as it has been termed, seems to be associated with a host of adverse effects contributing to many of the health problems that increase morbidity and decrease both quality of life and the ability to maintain independence in old age. For nurses to be truly informed when caring for older people and to ensure that they have a detailed understanding of the complexities of older people\u2019s health needs, they must have a knowledge of the physiological and immunological changes with age. This is the first of a two-part article on inflammatory processes in aging. These age-related changes are presented here, including an examination of the impact of genetic and lifestyle factors. The effect of these changes on the health of the individual and implications for practice are described in Part 2.<\/jats:p>","DOI":"10.1177\/1099800409352237","type":"journal-article","created":{"date-parts":[[2009,11,24]],"date-time":"2009-11-24T21:53:37Z","timestamp":1259099617000},"page":"245-252","source":"Crossref","is-referenced-by-count":38,"title":["Inflammation in Aging Part 1: Physiology and Immunological Mechanisms"],"prefix":"10.1177","volume":"11","author":[{"given":"Katherine J.","family":"Hunt","sequence":"first","affiliation":[{"name":"School of Health Sciences, University of Southampton,\rUnited Kingdom,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bronagh M.","family":"Walsh","sequence":"additional","affiliation":[{"name":"School of Health Sciences, University of Southampton,\rUnited Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Voegeli","sequence":"additional","affiliation":[{"name":"School of Health 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