{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T05:05:31Z","timestamp":1784955931366,"version":"3.55.0"},"reference-count":40,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Biological Research For Nursing"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:p>Objective: The purpose of this study was to examine the effect of neuropathic pain produced by peripheral nerve damage on mass, myofibrillar protein content, and cross-sectional areas of Type I and II fibers of rat hindlimb muscles. Method: Adult male Sprague-Dawley rats were assigned to one of three groups: a pain group (n = 10) that underwent ligation and cut of the left L5 spinal nerve, a sham group (n = 10) that underwent a sham cut procedure, or a control group (n = 10) that underwent no procedures. The withdrawal threshold test was done to assess pain threshold on each of Days 1\u20147 and 14. Activity, body weight, and food intake were measured daily for 2 weeks. At 15 days, rats were anesthetized and the bilateral soleus, plantaris, and gastrocnemius muscles dissected. Results: At 15 days postligation, the pain group had significant decreases in total dietary intake, body weight, activity, and muscle weight as compared to sham and control animals. Muscle weight and cross-sectional area of Type II fiber of the ipsilateral soleus, plantaris, and gastrocnemius muscles decreased as did myofibrillar protein content of the ipsilateral plantaris and gastrocnemius muscles. Muscle weight of the contralateral gastrocnemius muscle decreased, as did myofibrillar protein content and cross-sectional area of Type II fiber of the contralateral plantaris muscle. Conclusion: Hindlimb muscle atrophy occurs in both ipsilateral and contralateral sides following induction of neuropathic pain by unilateral peripheral nerve damage. Muscle changes of the ipsilateral side are more pronounced than those of the contralateral side.<\/jats:p>","DOI":"10.1177\/1099800410382291","type":"journal-article","created":{"date-parts":[[2011,1,3]],"date-time":"2011-01-03T00:58:07Z","timestamp":1294016287000},"page":"44-54","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Hindlimb Muscle Atrophy Occurs From Peripheral Nerve Damage in a Rat Neuropathic Pain Model"],"prefix":"10.1177","volume":"13","author":[{"given":"Myoung-Ae","family":"Choe","sequence":"first","affiliation":[{"name":"College of Nursing, Seoul National University, Seoul, Korea,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Kyung Hwa Kim","sequence":"additional","affiliation":[{"name":"College of Medicine, Seoul National University, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Gyeong Ju An","sequence":"additional","affiliation":[{"name":"Department of Nursing, Cheongju University, Cheongju, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung-Sook","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Nursing, Wonju Campus, Gangneung Wonju National University, Wonju, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Heitkemper","sequence":"additional","affiliation":[{"name":"Department of Biobehavioral Nursing & Health Systems, School of Nursing, University of Washington, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2011,1,2]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/129.12.2264"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000062826.70846.8D"},{"key":"atypb3","volume-title":"Protein methods","author":"Bollag, D.M.","year":"1996","edition":"2"},{"key":"atypb4","first-page":"240A","volume":"56","author":"Bosagh Zadeh, A.R.","year":"1997","journal-title":"Proceedings of the Nutrition Society"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1970.00480280083010"},{"key":"atypb6","volume-title":"Focus on pathophysiology","author":"Bullock, B.L.","year":"1999"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(94)90144-9"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1998.881bs.x"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1097\/00006199-200409000-00001"},{"key":"atypb10","first-page":"193","volume":"25","author":"Choe, M.A.","year":"1995","journal-title":"Journal of the Korean Academy of Nursing"},{"key":"atypb11","first-page":"88","volume":"10","author":"Choe, M.A.","year":"2008","journal-title":"Journal of Korean Biological Nursing Science"},{"key":"atypb12","first-page":"182","volume":"12","author":"Choe, M.A.","year":"1994","journal-title":"Korean Journal of Sports Medicine"},{"key":"atypb13","first-page":"71","volume":"1","author":"Choe, M.A.","year":"1999","journal-title":"Journal of Korean Biological Nursing Science"},{"key":"atypb14","volume-title":"Effects of d-amphetamine and chlorpromazine on the orienting response and general behavioral activity in rats (Unpublished doctoral dissertation)","author":"Chung, I.S.","year":"1975"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pa.20.040180.002301"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1097\/00002508-200211000-00001"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.60.11.1524"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1258\/002367791780808239"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2007.01486.x"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-007-0380-2"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-6712.2007.00450.x"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1002\/1615-9861(200205)2:5<543::AID-PROT543>3.0.CO;2-K"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880111205"},{"key":"atypb24","unstructured":"Kasper, C.E. 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