{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T13:55:12Z","timestamp":1777470912656,"version":"3.51.4"},"reference-count":38,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2018,2,6]],"date-time":"2018-02-06T00:00:00Z","timestamp":1517875200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Project of Science and Technology Department in Xuzhou","award":["KC14SH090"],"award-info":[{"award-number":["KC14SH090"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Biological Research For Nursing"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:p>Chronic pain (CP) adversely impacts people\u2019s health. However, the influence of CP on pregnant women and their fetuses remains unclear. Few reasonable interventions have been offered to these women. This study aimed to examine the effects of enriched environmental intervention (EEI) on the delivery outcome and offspring health of pregnant mice with CP. Forty pregnant mice were equally and randomly divided into four groups (control, sham, CP, and CP + EEI). Monoarthritis was induced by subcutaneous injection of the complete Freund\u2019s adjuvant (100 \u03bcg\/100 \u03bcl) into the left hind paw of mice on Day 0 of gestation. Sham mice received 100 \u00b5l of sterile phosphate-buffered saline subcutaneously. General health status and delivery outcomes of pregnant mice and general physical status, growth, and development of offspring were observed and compared between groups. CP mice exhibited less weight gain, higher rate of premature delivery, smaller litter size, lower live birth rate, lower filial birth weight, shorter filial tail length, and lower filial rates of achieving righting reflex and crawling compared to mice in the control\/sham\/CP + EEI groups. There were no significant differences between mice in the CP + EEI group and those in the control and sham groups. CP during pregnancy led to serious adverse impacts on both the mother and fetus mice in this study, and EEI was an effective treatment for these effects.<\/jats:p>","DOI":"10.1177\/1099800418754303","type":"journal-article","created":{"date-parts":[[2018,4,4]],"date-time":"2018-04-04T08:55:39Z","timestamp":1522832139000},"page":"264-271","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["The Effects of Enriched Environmental Intervention on the Parturition Outcome and Filial Health of Pregnant Mice With Chronic Pain"],"prefix":"10.1177","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4488-2431","authenticated-orcid":false,"given":"Fang","family":"Zhou","sequence":"first","affiliation":[{"name":"School of Nursing, Xuzhou Medical University, Xuzhou, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cui","family":"Chen","sequence":"additional","affiliation":[{"name":"ICU, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Nursing, Xuzhou Medical University, Xuzhou, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huihui","family":"Hu","sequence":"additional","affiliation":[{"name":"School of Nursing, Xuzhou Medical University, Xuzhou, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[{"name":"School of Nursing, Xuzhou Medical University, Xuzhou, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingchun","family":"Tan","sequence":"additional","affiliation":[{"name":"School of Nursing, Xuzhou Medical University, Xuzhou, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,2,6]]},"reference":[{"key":"bibr1-1099800418754303","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2007.10.005"},{"key":"bibr2-1099800418754303","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0155125"},{"key":"bibr3-1099800418754303","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-016-1992-z"},{"key":"bibr4-1099800418754303","doi-asserted-by":"publisher","DOI":"10.1016\/j.midw.2016.04.014"},{"key":"bibr5-1099800418754303","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2015.11.014"},{"key":"bibr6-1099800418754303","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2015.02.016"},{"key":"bibr7-1099800418754303","doi-asserted-by":"publisher","DOI":"10.1097\/01.j.pain.0000460347.77341.bd"},{"key":"bibr8-1099800418754303","doi-asserted-by":"publisher","DOI":"10.1186\/1824-7288-39-7"},{"key":"bibr9-1099800418754303","doi-asserted-by":"publisher","DOI":"10.1159\/000029163"},{"key":"bibr10-1099800418754303","first-page":"832","volume":"18","author":"Edmonds B. 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