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We aimed to examine frequency of reduced bone mass in women with SLE, and determine their potential associations with disease activity, damage accrual and SLE-related clinical markers. A cross-sectional study including 121 Caucasian pre-menopausal and postmenopausal women was conducted (mean age 49.2 \u00b1 12.4 years). The SLE Disease Activity Index (SLEDAI-2 K) and the SDI Damage Index were used to assess disease activity and disease-related damage, respectively. Bone mineral density (BMD) of the left femoral neck and lumbar spine (L2\u2013L4) were measured by dual-energy X-ray absorptiometry. Ten patients (8.3%) had osteoporosis, 63 (52.1%) patients had osteopenia and 6.8% of women had history of previous fracture. Patients with low bone mass had a significantly higher mean SDI (1.3 \u00b1 1.2 versus 0.7 \u00b1 1.0 p = 0.003). T-score at lumbar spine was inversely correlated with SDI score (r = -0.222, p = 0.014) and complement C3 level ( r = \u22120.206, p = .024). SDI scores were significantly different between patients with osteoporosis, osteopenia, and normal BMD after adjusting for covariates ( p = .004). There is a high prevalence of low BMD in Caucasian women with SLE, and this status was associated with higher damage accrual scores, supporting that disease damage may itself be a major contributor to the low BMD. Women with SLE with organ damage require regular bone status monitoring to prevent further musculoskeletal damage.<\/jats:p>","DOI":"10.1177\/10998004211005550","type":"journal-article","created":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T05:06:30Z","timestamp":1617167190000},"page":"575-583","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Disease Damage Accrual and Low Bone Mineral Density in Female Patients with Systemic Lupus Erythematosus"],"prefix":"10.1177","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9165-4349","authenticated-orcid":false,"given":"Mar\u00eda","family":"Correa-Rodr\u00edguez","sequence":"first","affiliation":[{"name":"Biohealth Research Institute in Granada (ibs.GRANADA), Pabell\u00f3n de consultas externas 2, Granada, Spain"},{"name":"Department of Nursing, Health Sciences Faculty, University of Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2720-7461","authenticated-orcid":false,"given":"Gabriela","family":"Pocovi-Gerardino","sequence":"additional","affiliation":[{"name":"Biohealth Research Institute in Granada (ibs.GRANADA), Pabell\u00f3n de consultas externas 2, Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9-Luis","family":"Callejas-Rubio","sequence":"additional","affiliation":[{"name":"Biohealth Research Institute in Granada (ibs.GRANADA), Pabell\u00f3n de consultas externas 2, Granada, Spain"},{"name":"Unidad de Enfermedades Autoinmunes Sist\u00e9micas, Servicio de Medicina Interna, Hospital Universitario San Cecilio, Avenida de la Investigaci\u00f3n, Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel","family":"R\u00edos-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Biohealth Research Institute in Granada (ibs.GRANADA), Pabell\u00f3n de consultas externas 2, Granada, Spain"},{"name":"Unidad de Enfermedades Autoinmunes Sist\u00e9micas, Servicio de Medicina Interna, Hospital Universitario San Cecilio, Avenida de la Investigaci\u00f3n, Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0263-7000","authenticated-orcid":false,"given":"Blanca","family":"Rueda-Medina","sequence":"additional","affiliation":[{"name":"Biohealth Research Institute in Granada (ibs.GRANADA), Pabell\u00f3n de consultas externas 2, Granada, Spain"},{"name":"Department of Nursing, Health Sciences Faculty, University of Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norberto","family":"Ortego-Centeno","sequence":"additional","affiliation":[{"name":"Biohealth Research Institute in Granada (ibs.GRANADA), Pabell\u00f3n de consultas externas 2, Granada, Spain"},{"name":"Department of Medicine, Faculty of Medicine, University of Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,3,31]]},"reference":[{"key":"bibr1-10998004211005550","doi-asserted-by":"crossref","unstructured":"Alele J. 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