{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T01:44:53Z","timestamp":1791855893754,"version":"4.3.4"},"reference-count":45,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2022,5,7]],"date-time":"2022-05-07T00:00:00Z","timestamp":1651881600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100015726","name":"Oncology Nursing Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015726","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005233","name":"American Nurses Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005233","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HHSN268201600018C"],"award-info":[{"award-number":["HHSN268201600018C"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HHSN268201600001C"],"award-info":[{"award-number":["HHSN268201600001C"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HHSN26820160"],"award-info":[{"award-number":["HHSN26820160"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R21HL152149"],"award-info":[{"award-number":["R21HL152149"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000056","name":"National Institute of Nursing Research","doi-asserted-by":"publisher","award":["F31NR018588"],"award-info":[{"award-number":["F31NR018588"]}],"id":[{"id":"10.13039\/100000056","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000056","name":"National Institute of Nursing Research","doi-asserted-by":"publisher","award":["T32NR016913"],"award-info":[{"award-number":["T32NR016913"]}],"id":[{"id":"10.13039\/100000056","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Biological Research For Nursing"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Studies examining biomarkers associated with fatigue in breast cancer survivors treated with radiation are limited. Therefore, we examined the longitudinal association between serum biomarkers and post-breast cancer fatigue in survivors treated with radiation: [oxidative stress] 8-hydroxyguanosine, myeloperoxidase; [inflammation] interleukin-6 (IL-6), c-reactive protein, growth differentiation factor-15 (GDF-15), placental growth factor, transforming growth factor-beta, [cardiac damage] cystatin-C, troponin-I.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In a secondary analysis, we included participants from the Women\u2019s Health Initiative if they had: a previous breast cancer diagnosis (stages I-III), no prior cardiovascular diseases, pre-and post-breast cancer serum samples drawn approximately 3\u00a0years apart, and fatigue measured using the Short-Form 36 vitality subscale at both serum collections. Biomarkers were measured using ELISA or RT-qPCR and modeled as the log\n                      <jats:sub>2<\/jats:sub>\n                      post-to pre-breast cancer ratio.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 180 women with a mean (SD) age of 67.0 (5.5) years were included. The mean (SD) vitality scores were 66.2 (17.2) and 59.7 (19.7) pre- and post-breast cancer, respectively. Using multivariable weighted linear regression, higher biomarker ratios of cystatin-C, IL-6, and GDF-15 were associated with a lower vitality score (i.e., higher fatigue). For example, for each 2-fold difference in cystatin-C biomarker ratio, the vitality score was lower by 7.31 points (95% CI: \u221214.2, \u22120.45).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Inflammatory and cardiac damage biomarkers are associated with fatigue in breast cancer survivors treated with radiation; however, these findings should be replicated in a larger sample. Biomarkers could be measured in clinical practice or assessed in risk prediction models to help identify patients at high risk for fatigue.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10998004221098113","type":"journal-article","created":{"date-parts":[[2022,5,7]],"date-time":"2022-05-07T07:20:28Z","timestamp":1651908028000},"page":"472-483","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Inflammatory, Oxidative Stress, and Cardiac Damage Biomarkers and Radiation-Induced Fatigue in Breast Cancer Survivors"],"prefix":"10.1177","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1380-5364","authenticated-orcid":false,"given":"Alexi","family":"Vasbinder","sequence":"first","affiliation":[{"name":"Department of Biobehavioral Nursing and Health Informatics, School of Nursing, University of Washington, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5472-478X","authenticated-orcid":false,"given":"Hilaire","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Biobehavioral Nursing and Health Informatics, School of Nursing, University of Washington, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oleg","family":"Zaslavksy","sequence":"additional","affiliation":[{"name":"Department of Biobehavioral Nursing and Health Informatics, School of Nursing, University of Washington, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan R.","family":"Heckbert","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazmus","family":"Saquib","sequence":"additional","affiliation":[{"name":"Research Unit, College of Medicine, Sulaiman AlRajhi University, Al Bukayriyah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aladdin H.","family":"Shadyab","sequence":"additional","affiliation":[{"name":"Herbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rowan T.","family":"Chlebowski","sequence":"additional","affiliation":[{"name":"Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Warsinger Martin","sequence":"additional","affiliation":[{"name":"Division of Cardiology, School of Medicine and Health Sciences, George Washington University, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Electra D.","family":"Paskett","sequence":"additional","affiliation":[{"name":"Department of Medicine, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerryn W.","family":"Reding","sequence":"additional","affiliation":[{"name":"Department of Biobehavioral Nursing and Health Informatics, School of Nursing, University of Washington, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,5,7]]},"reference":[{"key":"bibr1-10998004221098113","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw099"},{"key":"bibr2-10998004221098113","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-200009001-00009"},{"key":"bibr3-10998004221098113","doi-asserted-by":"publisher","DOI":"10.1097\/PPO.0000000000000065"},{"key":"bibr4-10998004221098113","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.36.4109"},{"key":"bibr5-10998004221098113","doi-asserted-by":"publisher","DOI":"10.1016\/S1047-2797(03)00043-7"},{"key":"bibr6-10998004221098113","doi-asserted-by":"publisher","DOI":"10.1177\/1758834017698643"},{"key":"bibr7-10998004221098113","doi-asserted-by":"publisher","DOI":"10.1185\/030079907X178757"},{"key":"bibr8-10998004221098113","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-200207000-00010"},{"key":"bibr9-10998004221098113","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2004.06.003"},{"key":"bibr10-10998004221098113","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-2584"},{"key":"bibr11-10998004221098113","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2014.127"},{"key":"bibr12-10998004221098113","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-011-1148-2"},{"issue":"6","key":"bibr13-10998004221098113","first-page":"309","volume":"49","author":"Casillas J. M.","year":"2006","journal-title":"Annals of Physical and Rehabilitation Medicine"},{"key":"bibr14-10998004221098113","doi-asserted-by":"publisher","DOI":"10.1111\/imj.13201"},{"key":"bibr15-10998004221098113","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2008.05.009"},{"key":"bibr16-10998004221098113","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2011.3965"},{"key":"bibr17-10998004221098113","doi-asserted-by":"publisher","DOI":"10.1042\/CS20160479"},{"key":"bibr18-10998004221098113","doi-asserted-by":"publisher","DOI":"10.1188\/14.ONF.E238-E247"},{"key":"bibr19-10998004221098113","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.12-S1-4"},{"key":"bibr20-10998004221098113","doi-asserted-by":"publisher","DOI":"10.1080\/23809000.2016.1191948"},{"key":"bibr21-10998004221098113","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.644286"},{"key":"bibr22-10998004221098113","doi-asserted-by":"publisher","DOI":"10.1016\/j.plabm.2017.05.005"},{"key":"bibr23-10998004221098113","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-010-0016-0"},{"key":"bibr24-10998004221098113","doi-asserted-by":"publisher","DOI":"10.1159\/000509410"},{"key":"bibr25-10998004221098113","first-page":"82","volume":"22","author":"LaVoy E. C. P.","year":"2016","journal-title":"Exercise Immunology Review"},{"key":"bibr26-10998004221098113","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.303633"},{"key":"bibr27-10998004221098113","doi-asserted-by":"publisher","DOI":"10.21037\/tcr.2020.03.30"},{"issue":"10","key":"bibr28-10998004221098113","first-page":"1331","volume":"290","author":"McTiernan A.","year":"2003","journal-title":"Journal of the Society of Laparoendoscopic Surgeons"},{"key":"bibr29-10998004221098113","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21349"},{"key":"bibr30-10998004221098113","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.20424"},{"key":"bibr31-10998004221098113","doi-asserted-by":"publisher","DOI":"10.1002\/clc.22634"},{"key":"bibr32-10998004221098113","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-17-0581"},{"key":"bibr33-10998004221098113","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2015.241232"},{"key":"bibr34-10998004221098113","doi-asserted-by":"publisher","DOI":"10.1002\/sim.2398"},{"key":"bibr35-10998004221098113","doi-asserted-by":"publisher","DOI":"10.1177\/1534735418766402"},{"key":"bibr36-10998004221098113","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e318060d25c"},{"key":"bibr37-10998004221098113","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2012.05.004"},{"key":"bibr38-10998004221098113","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-015-2763-0"},{"key":"bibr39-10998004221098113","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-142-7-200504050-00008"},{"key":"bibr40-10998004221098113","doi-asserted-by":"publisher","DOI":"10.29220\/CSAM.2019.26.2.103"},{"key":"bibr41-10998004221098113","doi-asserted-by":"publisher","DOI":"10.1093\/jncics\/pkaa037"},{"key":"bibr42-10998004221098113","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2003.06.003"},{"key":"bibr43-10998004221098113","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2015.00039"},{"key":"bibr44-10998004221098113","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2014.10.013"},{"key":"bibr45-10998004221098113","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-200012150-00008"}],"container-title":["Biological Research For Nursing"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10998004221098113","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10998004221098113","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10998004221098113","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T13:38:32Z","timestamp":1777383512000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1177\/10998004221098113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,7]]},"references-count":45,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1177\/10998004221098113"],"URL":"https:\/\/doi.org\/10.1177\/10998004221098113","relation":{},"ISSN":["1099-8004","1552-4175"],"issn-type":[{"value":"1099-8004","type":"print"},{"value":"1552-4175","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,7]]}}}