{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T01:36:57Z","timestamp":1778549817630,"version":"3.51.4"},"reference-count":40,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T00:00:00Z","timestamp":1665014400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2019R1F1A1062965"],"award-info":[{"award-number":["NRF-2019R1F1A1062965"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Biological Research For Nursing"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:p>\n                    Food restriction (FR) enhances sensitivity to cardiopulmonary reflexes and \u03b11-adrenoreceptors in females in the presence of hypotension. However, the effect of FR on cardiopulmonary and vascular function in males is not well-understood. This study examines the effects of FR on cardiopulmonary, isolated arterial function, and potential underlying mechanisms. Male Sprague\u2013Dawley (SD) rats were randomly divided into 3 groups and monitored for 5\u00a0weeks: (1) control (n = 30), (2) 20% food reduction (FR20, n = 30), and (3) 40% food reduction (FR40, n = 30). Non-invasive blood pressure was measured twice a week. Pulmonary arterial pressure (PAP) was measured using isolated\/perfused lungs. The isolated vascular reactivity was assessed using double-wire myographs. FR rats exhibited a lower mean arterial pressure and heart rate; however, only the FR40 group exhibited statistically significant differences. We observed that FR enhanced sensitivity (EC\n                    <jats:sub>50<\/jats:sub>\n                    ) to vasoconstriction induced by the \u03b11-adrenoreceptor phenylephrine (PhE) but not to serotonin, U46619, or high K\n                    <jats:sup>+<\/jats:sup>\n                    in the mesenteric arteries. PhE-mediated vasoconstriction in the mesenteric arteries was eliminated in the presence of the eNOS inhibitor (L-NAME). In addition, incubation with NOX2\/4 inhibitors (apocynin, GKT137831, and VAS2870) and the reactive oxygen species (ROS) scavenger inhibitor (Tiron) eliminated the differences in PhE-mediated vasoconstriction, but the cyclooxygenase inhibitor (indomethacin) in the mesenteric arteries did not. Augmentation of \u03b11-adrenergic-mediated contraction via the inhibition of the eNOS-NO pathway increased the activation of ROS through NOX2\/4 in response to FR. Reduced eNOS-NO signaling may be a pathophysiological counterbalance to prevent hypovolemic shock in response to FR.\n                  <\/jats:p>","DOI":"10.1177\/10998004221132247","type":"journal-article","created":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T23:45:42Z","timestamp":1665099942000},"page":"198-209","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Food Restriction Augmented Alpha1\u2013Adrenergic Mediated Contraction in Mesenteric Arteries"],"prefix":"10.1177","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9158-9302","authenticated-orcid":false,"given":"Rany","family":"Vorn","sequence":"first","affiliation":[{"name":"Department of Nursing, Chung-Ang University, Seoul, Korea"},{"name":"School of Nursing, Johns Hopkins University, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9971-9036","authenticated-orcid":false,"given":"Hae Young","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Nursing, Chung-Ang University, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,10,6]]},"reference":[{"key":"bibr1-10998004221132247","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000051384.43104.FC"},{"key":"bibr2-10998004221132247","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.116.307210"},{"key":"bibr3-10998004221132247","doi-asserted-by":"publisher","DOI":"10.1079\/BJN20041392"},{"key":"bibr4-10998004221132247","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13828"},{"key":"bibr5-10998004221132247","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4557"},{"key":"bibr6-10998004221132247","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2007.02.001"},{"key":"bibr7-10998004221132247","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2015.02.007"},{"key":"bibr8-10998004221132247","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-28593-6"},{"key":"bibr9-10998004221132247","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.110.154732"},{"key":"bibr10-10998004221132247","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3403"},{"key":"bibr11-10998004221132247","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-015-0255-y"},{"key":"bibr12-10998004221132247","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2017.224"},{"key":"bibr13-10998004221132247","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0308291101"},{"key":"bibr14-10998004221132247","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2006.10.028"},{"key":"bibr15-10998004221132247","doi-asserted-by":"publisher","DOI":"10.2174\/157016112798829823"},{"key":"bibr16-10998004221132247","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.306301"},{"key":"bibr17-10998004221132247","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.86.5.494"},{"key":"bibr18-10998004221132247","doi-asserted-by":"publisher","DOI":"10.1186\/1423-0127-21-3"},{"key":"bibr19-10998004221132247","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2013.01.006"},{"key":"bibr20-10998004221132247","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.05.042"},{"key":"bibr21-10998004221132247","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.12125"},{"key":"bibr22-10998004221132247","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-015-2327-0"},{"key":"bibr23-10998004221132247","doi-asserted-by":"publisher","DOI":"10.5688\/aj710478"},{"key":"bibr24-10998004221132247","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1999.87.5.1909"},{"key":"bibr25-10998004221132247","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020369"},{"key":"bibr26-10998004221132247","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000350"},{"key":"bibr27-10998004221132247","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq396"},{"key":"bibr28-10998004221132247","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/156146"},{"key":"bibr29-10998004221132247","doi-asserted-by":"publisher","DOI":"10.1016\/j.carpath.2009.08.001"},{"key":"bibr30-10998004221132247","doi-asserted-by":"publisher","DOI":"10.2174\/1874192401004010302"},{"key":"bibr31-10998004221132247","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2006.05.017"},{"key":"bibr32-10998004221132247","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9384(03)00103-3"},{"key":"bibr33-10998004221132247","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00013908"},{"key":"bibr34-10998004221132247","doi-asserted-by":"publisher","DOI":"10.2174\/157016112798829760"},{"key":"bibr35-10998004221132247","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2008.161430"},{"key":"bibr36-10998004221132247","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0106463"},{"key":"bibr37-10998004221132247","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2011.01249.x"},{"key":"bibr38-10998004221132247","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00153.2011"},{"key":"bibr39-10998004221132247","doi-asserted-by":"publisher","DOI":"10.3390\/jcm3031050"},{"key":"bibr40-10998004221132247","doi-asserted-by":"publisher","DOI":"10.1007\/s13105-011-0123-1"}],"container-title":["Biological 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