{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T06:55:55Z","timestamp":1790924155213,"version":"4.1.0"},"reference-count":32,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T00:00:00Z","timestamp":1673222400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100012400","name":"Sigma Theta Tau International","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012400","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institute of Health","award":["R01NR001094"],"award-info":[{"award-number":["R01NR001094"]}]},{"name":"National Institute of Health","award":["R01NR014479"],"award-info":[{"award-number":["R01NR014479"]}]},{"DOI":"10.13039\/100012375","name":"University of Washington School of Nursing","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012375","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000056","name":"National Institute of Nursing Research","doi-asserted-by":"publisher","award":["K23NR020044"],"award-info":[{"award-number":["K23NR020044"]}],"id":[{"id":"10.13039\/100000056","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000056","name":"National Institute of Nursing Research","doi-asserted-by":"publisher","award":["NIDDK P30-DK56338"],"award-info":[{"award-number":["NIDDK P30-DK56338"]}],"id":[{"id":"10.13039\/100000056","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000056","name":"National Institute of Nursing Research","doi-asserted-by":"publisher","award":["NINR R01-NR013497"],"award-info":[{"award-number":["NINR R01-NR013497"]}],"id":[{"id":"10.13039\/100000056","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000056","name":"National Institute of Nursing Research","doi-asserted-by":"publisher","award":["R01DK130517"],"award-info":[{"award-number":["R01DK130517"]}],"id":[{"id":"10.13039\/100000056","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Biological Research For Nursing"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:p>Irritable bowel syndrome (IBS) is a common disorder of gut-brain interaction with multifaceted pathophysiology. Prior studies have demonstrated higher rates of vitamin D deficiency in individuals with IBS compared to healthy controls (HC), as well as associations of vitamin D concentration with IBS symptoms. A systematic review of 10 mouse and 14 human studies reported a positive association between vitamin D (serum levels and supplementation) and beta diversity of gut microbiome in a variety of conditions. The present retrospective case-control study aimed to compare vitamin D (25(OH)D) plasma concentrations and gut microbiome composition in adult women with IBS (n=99) and HC (n=62). Plasma concentrations of 25(OH)D were assessed using the Endocrine Society Guidelines definition of vitamin D deficiency (25(OH)D &lt;20 ng\/ml) and insufficiency (25(OH)D &gt;20-&lt;30 ng\/ml). 16S rRNA microbiome gene sequencing data was available for 39 HC and 62 participants with IBS. Genus-level Bifidobacterium and Lactobacillus and phylum-level Firmicutes and Bacteroidetes relative abundances were extracted from microbiome profiles. Results showed vitamin D deficiency in 40.3% (n=25) vs. 41.4% (n=41), and insufficiency 33.9% (n=21) vs. 34.3% (n=34) in the HCs vs. IBS groups, respectively. The odds of IBS did not differ depending on 25(OH)D status (p=0.75 for deficient, p=0.78 for insufficient), and the average plasma vitamin D concentration did not differ between IBS (mean 24.8 ng\/ml) and HCs (mean 25.1 ng\/ml; p=0.57). We did not find evidence of an association between plasma 25(OH)D concentration and richness, Shannon index, Simpson index or specific bacterial abundances in either HCs or the IBS group.<\/jats:p>","DOI":"10.1177\/10998004221150395","type":"journal-article","created":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T00:03:28Z","timestamp":1673309008000},"page":"436-443","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Exploring the Role of Vitamin D and the Gut Microbiome: A Cross-Sectional Study of Individuals with Irritable Bowel Syndrome and Healthy Controls"],"prefix":"10.1177","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2840-642X","authenticated-orcid":false,"given":"Sarah W.","family":"Matthews","sequence":"first","affiliation":[{"name":"School of Nursing, University of Washington, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Plantinga","sequence":"additional","affiliation":[{"name":"Williams College, Williamstown, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Burr","sequence":"additional","affiliation":[{"name":"School of Nursing, University of Washington, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin C.","family":"Cain","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Office for Nursing Research, School of Nursing, University of Washington, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tor","family":"Savidge","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA"},{"name":"Department of Pathology, Texas Children\u2019s Microbiome Center, Texas Children\u2019s Hospital, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7753-3564","authenticated-orcid":false,"given":"Kendra","family":"Kamp","sequence":"additional","affiliation":[{"name":"School of Nursing, University of Washington, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret M.","family":"Heitkemper","sequence":"additional","affiliation":[{"name":"School of Nursing, University of Washington, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,1,9]]},"reference":[{"key":"bibr2-10998004221150395","first-page":"1","author":"Alonso N.","year":"2022","journal-title":"Calcified Tissue International"},{"key":"bibr3-10998004221150395","doi-asserted-by":"publisher","DOI":"10.11131\/2018\/101377"},{"key":"bibr4-10998004221150395","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22010362"},{"key":"bibr5-10998004221150395","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.15891"},{"key":"bibr7-10998004221150395","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.15852"},{"key":"bibr8-10998004221150395","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.12432"},{"key":"bibr9-10998004221150395","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i7.2219"},{"issue":"11","key":"bibr10-10998004221150395","first-page":"694","volume":"13","author":"Drossman D. A.","year":"2017","journal-title":"Gastroenterology Hepatology (N Y)"},{"key":"bibr11-10998004221150395","doi-asserted-by":"publisher","DOI":"10.1038\/s41395-018-0262-x"},{"key":"bibr12-10998004221150395","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2021.08.006"},{"key":"bibr13-10998004221150395","doi-asserted-by":"publisher","DOI":"10.3945\/jn.111.151977"},{"key":"bibr14-10998004221150395","doi-asserted-by":"publisher","DOI":"10.1186\/s12934-022-01858-6"},{"key":"bibr15-10998004221150395","doi-asserted-by":"publisher","DOI":"10.1080\/00325481.2017.1383819"},{"key":"bibr16-10998004221150395","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-0385"},{"key":"bibr17-10998004221150395","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000001107"},{"key":"bibr18-10998004221150395","doi-asserted-by":"publisher","DOI":"10.1186\/s12937-022-00777-x"},{"key":"bibr19-10998004221150395","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12812"},{"key":"bibr20-10998004221150395","doi-asserted-by":"publisher","DOI":"10.1177\/1099800420941255"},{"key":"bibr35-10998004221150395","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2015.01.011"},{"key":"bibr23-10998004221150395","doi-asserted-by":"publisher","DOI":"10.1097\/SGA.0000000000000634"},{"key":"bibr36-10998004221150395","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S174982"},{"key":"bibr25-10998004221150395","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(20)30217-X"},{"key":"bibr26-10998004221150395","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-017-1175-y"},{"key":"bibr27-10998004221150395","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-018-9239-3"},{"key":"bibr28-10998004221150395","first-page":"9896743","volume":"2020","author":"Wang X.","year":"2020","journal-title":"BioMed Research International"},{"key":"bibr29-10998004221150395","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-018-1842-7"},{"key":"bibr30-10998004221150395","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-021-02633-w"},{"key":"bibr31-10998004221150395","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00105.2015"},{"key":"bibr32-10998004221150395","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-307436"},{"key":"bibr37-10998004221150395","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.03141"},{"key":"bibr33-10998004221150395","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2021-0792"},{"key":"bibr34-10998004221150395","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2015.04.003"}],"container-title":["Biological Research For Nursing"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10998004221150395","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10998004221150395","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10998004221150395","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T13:38:39Z","timestamp":1777383519000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10998004221150395"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,9]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["10.1177\/10998004221150395"],"URL":"https:\/\/doi.org\/10.1177\/10998004221150395","relation":{},"ISSN":["1099-8004","1552-4175"],"issn-type":[{"value":"1099-8004","type":"print"},{"value":"1552-4175","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,9]]}}}