{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T21:16:13Z","timestamp":1789420573091,"version":"build-2803163510"},"reference-count":54,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2023,5,28]],"date-time":"2023-05-28T00:00:00Z","timestamp":1685232000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Biological Research For Nursing"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Preeclampsia (PE) is a multifunctional and multisystem disorder. Several factors favor the development of PE, including obesity. Cytokines are also expressed in the placenta, predisposing to local alterations that favor the development of distinct pathological processes, including PE. This study aimed to evaluate the apelin and visfatin mRNA expression in the placental tissue of women with preeclampsia and overweight\/obesity and correlates with maternal and fetal variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross-sectional analytical study was performed with 60 pregnant women and their newborns. Clinical, anthropometric, and laboratory variables were collected. Placental tissue samples were obtained, and the apelin and visfatin mRNA expression levels were assessed by qRT-PCR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The main findings evidenced lower levels of apelin expression in overweight\/obese women, accompanied by a negative correlation with BMI and pre-pregnancy weight; a higher expression of apelin was also observed in women with late PE and no personal history of PE. For visfatin levels, higher expression levels were observed in women with late PE and term delivery. Furthermore, a positive correlation was observed between visfatin levels and fetal anthropometric parameters, such as weight, length, and head circumference.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Apelin levels were less expressed in overweight\/obese women. Apelin and visfatin levels were correlated\/associated with maternal-fetal variables.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10998004231178835","type":"journal-article","created":{"date-parts":[[2023,5,28]],"date-time":"2023-05-28T23:26:56Z","timestamp":1685316416000},"page":"647-657","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Apelin and Visfatin Expression in Placental Tissue in Women With Preeclampsia and Overweight\/Obesity"],"prefix":"10.1177","volume":"25","author":[{"given":"Ana Paula dos Santos Xavier","family":"Braga","sequence":"first","affiliation":[{"name":"Graduate Program in Health Sciences, State University of Montes Claros (Unimontes), Montes Claros, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana Matos","family":"Silva","sequence":"additional","affiliation":[{"name":"Graduate Program in Health Sciences, State University of Montes Claros (Unimontes), Montes Claros, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"de Farias Lelis","sequence":"additional","affiliation":[{"name":"Graduate Program in Health Sciences, State University of Montes Claros (Unimontes), Montes Claros, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rog\u00e9rio Estevam","family":"Farias","sequence":"additional","affiliation":[{"name":"Department of Pathology, Federal University of Juiz de Fora (UFJF), Juiz de Fora, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alanna Fernandes","family":"Para\u00edso","sequence":"additional","affiliation":[{"name":"Departament of Nursing, Federal University of Juiz de Fora (UFJF), Juiz de Fora, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7788-5447","authenticated-orcid":false,"given":"S\u00e9rgio Henrique Sousa","family":"Santos","sequence":"additional","affiliation":[{"name":"Graduate Program in Health Sciences, State University of Montes Claros (Unimontes), Montes Claros, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Maria Eleut\u00e9rio de Barros Lima","family":"Martins","sequence":"additional","affiliation":[{"name":"Graduate Program in Health Sciences, State University of Montes Claros (Unimontes), Montes Claros, Brazil"},{"name":"Department of Odontology, Montes Claros State University (Unimontes), Montes Claros, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5705-0824","authenticated-orcid":false,"given":"Jo\u00e3o Marcus Oliveira","family":"Andrade","sequence":"additional","affiliation":[{"name":"Graduate Program in Health Sciences, State University of Montes Claros (Unimontes), Montes Claros, Brazil"},{"name":"Department of Pathophysiology, State University of Montes Claros (Unimontes), Montes Claros, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,5,28]]},"reference":[{"key":"bibr1-10998004231178835","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v10.i30.10840"},{"key":"bibr2-10998004231178835","doi-asserted-by":"publisher","DOI":"10.3390\/cells11091548"},{"key":"bibr3-10998004231178835","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2014.122"},{"key":"bibr4-10998004231178835","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2020.1789581"},{"key":"bibr52-10998004231178835","doi-asserted-by":"publisher","DOI":"10.2337\/db11-0100"},{"key":"bibr5-10998004231178835","doi-asserted-by":"publisher","DOI":"10.1186\/s40885-020-00152-0"},{"key":"bibr6-10998004231178835","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-019-0176-8"},{"key":"bibr7-10998004231178835","doi-asserted-by":"publisher","DOI":"10.3109\/10641955.2012.690054"},{"key":"bibr8-10998004231178835","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.117.10803"},{"key":"bibr9-10998004231178835","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l2381"},{"issue":"3","key":"bibr10-10998004231178835","doi-asserted-by":"crossref","first-page":"257","DOI":"10.59566\/IJBS.2009.5257","volume":"5","author":"Cekmez F.","year":"2009","journal-title":"International Journal of Biomedical Science: IJBS"},{"key":"bibr11-10998004231178835","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00023.2022"},{"issue":"10","key":"bibr13-10998004231178835","first-page":"3343","volume":"118","author":"Chun H. 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