{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T13:45:52Z","timestamp":1777470352595,"version":"3.51.4"},"reference-count":46,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T00:00:00Z","timestamp":1717113600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Tina L. Bachas Oncology Nursing Research Award"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Biological Research For Nursing"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:p>Background: Hematopoietic Stem Cell Transplant (HCT) is a potentially curative treatment for hematologic malignancies, including multiple myeloma. Biomarker investigation can guide identification of HCT recipients at-risk for poor outcomes. MicroRNAs (miRNAs) are a class of non-coding RNAs involved in the modulation and regulation of pathological processes and are emerging as prognostic and predictive biomarkers for multiple health conditions. This pilot study aimed to examine miRNA profiles associated with HCT-related risk factors and outcomes in patients undergoing autologous HCT. Methods: Patients eligible for autologous HCT were recruited and blood samples and HCT-related variables were collected. Differential expression analysis of miRNA was conducted on 24 patient samples to compare changes in miRNA profile in HCT eligible patients before and after transplant. Results: Unsupervised clustering of differentially expressed ( p &lt; .05) miRNAs pre- and post- HCT identified clusters of up- and down-regulated miRNAs. Four miRNAs (miR-125a-5p, miR-99b-5p, miR-382\u20135p, miR-145\u20135p) involved in hematopoiesis (differentiation of progenitor cells, granulocyte function, thrombopoiesis, and tumor suppression) were significantly downregulated post-HCT. Correlation analyses identified select miRNAs associated with risk factors (such as frailty, fatigue, cognitive decline) and quality of life pre- and post-HCT. Select miRNAs were correlated with platelet engraftment. Conclusion: Future studies should examine miRNA signatures in larger cohorts in association with HCT outcomes; and expand investigations in patients receiving allogeneic transplants. This will lead to identification of biomarkers for risk stratification of HCT recipients.<\/jats:p>","DOI":"10.1177\/10998004241257847","type":"journal-article","created":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T11:38:18Z","timestamp":1717155498000},"page":"559-568","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["MicroRNA Profiles in Hematopoietic Stem Cell Transplant Recipients"],"prefix":"10.1177","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5504-1518","authenticated-orcid":false,"given":"Lathika","family":"Mohanraj","sequence":"first","affiliation":[{"name":"Department of Adult Health and Nursing Systems, School of Nursing, Virginia Commonwealth University, Richmond, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christiane","family":"Carter","sequence":"additional","affiliation":[{"name":"Bioinformatics Shared Resource, Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinze","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, School of Population Health, Virginia Commonwealth University, Richmond, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theresa","family":"Swift-Scanlan","sequence":"additional","affiliation":[{"name":"School of Nursing, Virginia Commonwealth University, Richmond, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,5,31]]},"reference":[{"key":"bibr1-10998004241257847","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21758"},{"key":"bibr2-10998004241257847","doi-asserted-by":"publisher","DOI":"10.1038\/nature02871"},{"key":"bibr3-10998004241257847","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.2013.796356"},{"key":"bibr4-10998004241257847","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-0496"},{"key":"bibr5-10998004241257847","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33313"},{"key":"bibr6-10998004241257847","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2021.102624"},{"key":"bibr7-10998004241257847","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2011.051730"},{"key":"bibr8-10998004241257847","volume-title":"Current use and outcome of hematopoietic stem cell transplantation: CIBMTR summary slides","author":"Bolon Y.","year":"2022"},{"key":"bibr9-10998004241257847","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-018-0146-0"},{"key":"bibr10-10998004241257847","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2011.147"},{"key":"bibr11-10998004241257847","doi-asserted-by":"publisher","DOI":"10.3390\/biology11081151"},{"key":"bibr12-10998004241257847","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V92.5.1471"},{"key":"bibr13-10998004241257847","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2020.07.023"},{"key":"bibr14-10998004241257847","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3765"},{"key":"bibr15-10998004241257847","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1379"},{"key":"bibr16-10998004241257847","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23105355"},{"key":"bibr17-10998004241257847","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(12)70073-6"},{"key":"bibr18-10998004241257847","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt703"},{"key":"bibr19-10998004241257847","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1188853"},{"key":"bibr20-10998004241257847","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04831-3"},{"key":"bibr21-10998004241257847","volume-title":"The multiple dimensions of frailty: Physical capacity, cognition, and quality of life.","author":"Langlois F.","year":"2012"},{"key":"bibr22-10998004241257847","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2014.08.033"},{"key":"bibr23-10998004241257847","unstructured":"Leukemia and Lymphoma Society. (2022). Facts and statistics overview."},{"issue":"6","key":"bibr24-10998004241257847","first-page":"8332","volume":"17","author":"Liang H.","year":"2018","journal-title":"Molecular Medicine Reports"},{"key":"bibr25-10998004241257847","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.1199"},{"key":"bibr26-10998004241257847","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2018.11.012"},{"key":"bibr27-10998004241257847","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"bibr28-10998004241257847","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000002966"},{"key":"bibr29-10998004241257847","doi-asserted-by":"crossref","unstructured":"Mohanraj L., Wolf H., Silvey S., Liu J., Toor A., Swift-Scanlan T. (2022). DNA methylation changes in autologous hematopoietic stem cell transplant patients. Biological Research For Nursing, p. 10998004221135628. https:\/\/doi.org\/10.1177\/10998004221135628","DOI":"10.1177\/10998004221135628"},{"key":"bibr30-10998004241257847","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16805-5"},{"key":"bibr31-10998004241257847","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1009798107"},{"key":"bibr32-10998004241257847","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2019.07.030"},{"key":"bibr33-10998004241257847","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2010.09.005"},{"key":"bibr34-10998004241257847","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2018.11.005"},{"key":"bibr35-10998004241257847","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2008.04.013"},{"key":"bibr36-10998004241257847","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-04-281600"},{"key":"bibr37-10998004241257847","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26590"},{"key":"bibr38-10998004241257847","unstructured":"Revelle W. (2023). psych: Procedures for psychological, psychometric, and personality research. Northwestern University. https:\/\/cran.r-project.org\/package=psych"},{"key":"bibr39-10998004241257847","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15092658"},{"key":"bibr40-10998004241257847","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20160759"},{"key":"bibr41-10998004241257847","doi-asserted-by":"publisher","DOI":"10.1016\/j.soncn.2021.151179"},{"key":"bibr42-10998004241257847","doi-asserted-by":"publisher","DOI":"10.1002\/wrna.121"},{"key":"bibr43-10998004241257847","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14211"},{"key":"bibr44-10998004241257847","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2014.06.010"},{"key":"bibr45-10998004241257847","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2011.08782.x"},{"key":"bibr46-10998004241257847","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-05227-6"}],"container-title":["Biological Research For Nursing"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10998004241257847","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10998004241257847","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10998004241257847","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T13:38:50Z","timestamp":1777383530000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10998004241257847"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,31]]},"references-count":46,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1177\/10998004241257847"],"URL":"https:\/\/doi.org\/10.1177\/10998004241257847","relation":{},"ISSN":["1099-8004","1552-4175"],"issn-type":[{"value":"1099-8004","type":"print"},{"value":"1552-4175","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,31]]}}}