{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T13:45:59Z","timestamp":1777470359601,"version":"3.51.4"},"reference-count":78,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T00:00:00Z","timestamp":1718150400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81903334"],"award-info":[{"award-number":["81903334"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Biological Research For Nursing"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:p>The purpose of this study was to explore whether prenatal gut microbiota (GM) and its functions predict the development of offspring temperament. A total of 53 mothers with a 1-year-old child and 41 mothers with a 2-year-old child were included in this study using a mother-infant cohort from central China. Maternal fecal samples collected during the third trimester were analyzed using 16S rRNA V3-V4 gene sequences. Temperament of the child was measured by self-reported data according to the primary caregiver. The effects of GM in mothers on offspring\u2019s temperament were evaluated using multiple linear regression models. The results demonstrated that the alpha diversity index Simpson of prenatal GM was positively associated with the activity level of offspring at 1\u00a0year (adj. P = .036). Bifidobacterium was positively associated with high-intensity pleasure characteristics of offspring at 1\u00a0year (adj. P = .031). Comparatively, the presence of Bifidobacterium found in the prenatal microbiome was associated with low-intensity pleasure characteristics in offspring at 2\u00a0years (adj. P = .031). There were many significant associations noted among the functional pathways of prenatal GM and temperament of offspring at 2\u00a0years. Our findings support the maternal-fetal GM axis in the setting of fetal-placental development with subsequent postnatal neurocognitive developmental outcomes, and suggest that early childhood temperament is in part associated with specific GM in the prenatal setting.<\/jats:p>","DOI":"10.1177\/10998004241260894","type":"journal-article","created":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T11:41:25Z","timestamp":1718192485000},"page":"569-583","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Prenatal Gut Microbiota Predicts Temperament in Offspring at 1\u20132 Years"],"prefix":"10.1177","volume":"26","author":[{"given":"Yanan","family":"Cao","sequence":"first","affiliation":[{"name":"Center for Women\u2019s and Children\u2019s Health, Wuhan University School of Nursing, Wuhan, 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