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Kirschstein National Research Service Awards","award":["F31NR018363"],"award-info":[{"award-number":["F31NR018363"]}]},{"name":"National Institute for Nursing Research, Ruth L. Kirschstein National Research Service Awards","award":["T32NR014255"],"award-info":[{"award-number":["T32NR014255"]}]},{"name":"National Institutes of Health, National Institute for Minority Health and Health Disparities","award":["R01MD001575"],"award-info":[{"award-number":["R01MD001575"]}]},{"name":"Amendt-Heller Award for Newborn Research"},{"name":"National Institutes of Health, National Institute for Minority Health and Health Disparities","award":["5R01MD018293-02"],"award-info":[{"award-number":["5R01MD018293-02"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Biological Research For Nursing"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:p>Preterm birth (PTB; &lt;37\u00a0weeks completed gestation) is a devastating problem affecting over 13 million live births worldwide. In the U.S., African Americans experience significantly higher rates of PTB compared to non-Hispanic Whites. PTB disparities have been linked to social determinants of health (e.g., socioeconomic status, discrimination). However, the biological underpinnings related to these associations are unclear. DNA methylation (DNAm) is subject to environmental influences, and DNAm modifications are known to affect gene expression. Using a multi-omic approach, we examined differences in combined DNA methylation (DNAm) and messenger RNA (mRNA) transcriptomic data from 20 pregnant African American women (12 PTB; 8 term birth) early in pregnancy (8\u201318\u00a0weeks gestation). We found that the HLA- DQB2 gene was both differentially methylated (cg12296550; p = .02) and differentially expressed ( p = .014; log2FC = 2.5) between women with PTB and term birth. Gene expression analysis showed HLA- DQB2 and HLA- DRB4 ( p = .028; log2FC = \u22123.6) were the two most highly expressed genes. HLA-DQB2 expressed higher in PTB and HLA- DRB4 expressed higher in term birth. However, no genes remained significant ( p &lt; .05) after Bonferroni correction. HLA- DRB4 and AKR1C1 were identified as a potential biomarkers in dimensionality reduction models and are also important to immune function and allogenic breakdown. Altered gene expression may lead to inflammatory imbalances or allogenic intolerance resulting in PTB. This study provides proof-of-concept evidence for the feasibility and importance of future multi-omics studies with larger populations to further explore the genes and pathways identified here.<\/jats:p>","DOI":"10.1177\/10998004241275049","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T08:05:42Z","timestamp":1729670742000},"page":"205-215","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Preterm Birth in African American Women: A Multi-Omic Pilot Study in Early Pregnancy"],"prefix":"10.1177","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3457-593X","authenticated-orcid":false,"given":"Alexandra L.","family":"Nowak","sequence":"first","affiliation":[{"name":"Marcella Niehoff School of Nursing, Loyola University at Chicago, Maywood, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"Saadat","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, University of Michigan, Ann Arbor, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiao","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Computer Science, University of Central Florida, Orlando, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna M.","family":"Forsman","sequence":"additional","affiliation":[{"name":"Department of Biology, Colby College, Waterville, ME, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyu","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cara","family":"Joyce","sequence":"additional","affiliation":[{"name":"Biostatistics Core, Department of Medicine, Center for Translational Research and Education, Loyola University Chicago Stritch School of Medicine, Maywood, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Woo","sequence":"additional","affiliation":[{"name":"University of Texas at Arlington, Arlington, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher G.","family":"Engeland","sequence":"additional","affiliation":[{"name":"Biobehavioral Health, College of Health and Human Development, Ross and Carol Ness College of Nursing, The Pennsylvania State University, University Park, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dawn P.","family":"Misra","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, MSU College of Human Medicine, East Lansing, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4577-3184","authenticated-orcid":false,"given":"Carmen","family":"Giurgescu","sequence":"additional","affiliation":[{"name":"Chatlos Foundation Endowed Chair in Nursing, University of Central Florida College of Nursing, Orlando, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Computer Science, University of Central Florida, Orlando, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cindy M.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Maternal Infant Health, Martha S. Pitzer Center for Women, Children and Youth, The Ohio State University College of Nursing, Columbus, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,10,23]]},"reference":[{"key":"bibr1-10998004241275049","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3519"},{"key":"bibr2-10998004241275049","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232214138"},{"key":"bibr3-10998004241275049","first-page":"1","volume":"5","author":"Chatterjee P.","year":"2014","journal-title":"Frontiers in Immunology"},{"key":"bibr4-10998004241275049","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2010.09.007"},{"key":"bibr5-10998004241275049","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.911861"},{"key":"bibr6-10998004241275049","doi-asserted-by":"publisher","DOI":"10.1007\/s43032-020-00456-4"},{"key":"bibr7-10998004241275049","doi-asserted-by":"publisher","DOI":"10.1097\/GRF.0000000000000037"},{"key":"bibr8-10998004241275049","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa1113"},{"key":"bibr9-10998004241275049","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bty537"},{"key":"bibr10-10998004241275049","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2018.06.029"},{"key":"bibr11-10998004241275049","doi-asserted-by":"publisher","DOI":"10.1053\/j.nainr.2013.09.004"},{"key":"bibr12-10998004241275049","doi-asserted-by":"publisher","DOI":"10.1177\/01939459211041165"},{"key":"bibr13-10998004241275049","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2290018"},{"key":"bibr14-10998004241275049","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.107874"},{"key":"bibr15-10998004241275049","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2014.46"},{"key":"bibr16-10998004241275049","doi-asserted-by":"publisher","DOI":"10.15620\/cdc\/151797"},{"key":"bibr17-10998004241275049","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000001287"},{"key":"bibr50-10998004241275049","doi-asserted-by":"publisher","DOI":"10.1080\/15592294.2017.1287654"},{"key":"bibr18-10998004241275049","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkn923"},{"key":"bibr19-10998004241275049","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3230"},{"key":"bibr20-10998004241275049","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa970"},{"key":"bibr21-10998004241275049","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2010.07.008"},{"key":"bibr22-10998004241275049","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1716314116"},{"key":"bibr23-10998004241275049","volume-title":"A profile of prematurity in the United States","author":"March of Dimes Foundation","year":"2024"},{"key":"bibr24-10998004241275049","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-020-0471-2"},{"key":"bibr25-10998004241275049","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2010.05938.x"},{"key":"bibr26-10998004241275049","doi-asserted-by":"publisher","DOI":"10.1111\/sji.12329"},{"key":"bibr27-10998004241275049","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.16681"},{"key":"bibr28-10998004241275049","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11565"},{"key":"bibr29-10998004241275049","doi-asserted-by":"publisher","DOI":"10.1177\/10998004221099253"},{"issue":"44","key":"bibr30-10998004241275049","first-page":"D733","volume":"4","author":"O\u2019Leary N. 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