{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T15:10:31Z","timestamp":1784819431117,"version":"3.55.0"},"reference-count":52,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T00:00:00Z","timestamp":1752019200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Biological Research For Nursing"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    <jats:bold>Background<\/jats:bold>\n                    : Chemotherapy-induced nausea and vomiting (CINV) represent prevalent and distressing adverse effects among cancer patients, substantially compromising treatment compliance and quality of life. This systematic review and meta-analysis evaluate the therapeutic efficacy of aromatherapy in managing CINV, with the objective of informing evidence-based clinical decision-making in supportive cancer care.\n                    <jats:bold>Methods<\/jats:bold>\n                    : We systematically searched PubMed, Embase, and Cochrane Library for randomized controlled trials (RCTs) assessing aromatherapy\u2019s effects on CINV. Two reviewers independently screened studies, extracted data, and evaluated bias risk. Meta-analysis was performed using RevMan 5.4, with outcomes expressed as odds ratios (ORs) or mean differences (MDs) with 95% confidence intervals (CIs).\n                    <jats:bold>Results<\/jats:bold>\n                    : Twelve RCTs (n = 1,572) were included. Aromatherapy significantly reduced acute nausea (OR = 0.46, 95% CI 0.29\u20130.73), acute vomiting (OR = 0.56, 95% CI 0.40\u20130.79), and delayed nausea (OR = 0.64, 95% CI 0.47\u20130.88). However, no significant effects were observed for delayed vomiting (OR = 0.72, 95% CI 0.39\u20131.34), VAS scores (MD = \u22121.30, 95% CI \u22122.76\u20130.16), or INVR scores (MD = \u22121.67, 95% CI \u22123.67\u20130.32). No publication bias was detected (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &gt; 0.05).\n                    <jats:bold>Conclusion<\/jats:bold>\n                    : The existing body of evidence suggests that aromatherapy may function as a valuable adjunctive therapy in mitigating chemotherapy-induced nausea, especially during the acute phase. Nevertheless, its efficacy in managing vomiting and symptoms in the delayed phase remains uncertain. Future research efforts should focus on conducting large-scale, methodologically robust RCTs that employ standardized aromatherapy protocols and incorporate longitudinal assessments of outcomes and understanding the biological mechanisms associated with aromatherapy therapeutic effects.\n                  <\/jats:p>","DOI":"10.1177\/10998004251356515","type":"journal-article","created":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T13:02:23Z","timestamp":1752066143000},"page":"16-29","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Systematic Review and Meta-Analysis of Aromatherapy in Alleviating Post-Chemotherapy Nausea and Vomiting Among Cancer Patients"],"prefix":"10.1177","volume":"28","author":[{"given":"Xin","family":"Zhang","sequence":"first","affiliation":[{"name":"Quanzhou Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yining","family":"Wang","sequence":"additional","affiliation":[{"name":"Guangzhou Nanyang Polytechnic College, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"He","sequence":"additional","affiliation":[{"name":"Quanzhou Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Li","sequence":"additional","affiliation":[{"name":"Quanzhou Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1190-1583","authenticated-orcid":false,"given":"Yanbin","family":"Wang","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Shanghai Sixth People's Hospital Fujian, Quanzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,7,9]]},"reference":[{"key":"e_1_3_5_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/jicm.2022.0601"},{"key":"e_1_3_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctcp.2024.101838"},{"key":"e_1_3_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-024-08837-0"},{"key":"e_1_3_5_5_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4NA00678J"},{"key":"e_1_3_5_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/JMDH.S507759"},{"key":"e_1_3_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jopan.2023.06.096"},{"key":"e_1_3_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jopan.2024.03.008"},{"issue":"1","key":"e_1_3_5_9_1","first-page":"E1","article-title":"A randomized controlled trial of aromatherapy to reduce symptom burden in patients undergoing hematopoietic stem cell transplantation","volume":"52","author":"Bates M.","year":"2024","unstructured":"Bates M., Thullen A., Basham L., Carter A., Keen A. (2024). A randomized controlled trial of aromatherapy to reduce symptom burden in patients undergoing hematopoietic stem cell transplantation. Oncology Nursing Forum, 52(1), E1\u2013E11. https:\/\/doi.org\/10.1188\/25.ONF.E1-E11","journal-title":"Oncology Nursing Forum"},{"key":"e_1_3_5_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx315"},{"issue":"3","key":"e_1_3_5_11_1","first-page":"400","article-title":"Aromatherapy and essential oils: Holistic strategies in complementary and alternative medicine for integral wellbeing","volume":"14","author":"Caballero-Gallardo K.","year":"2025","unstructured":"Caballero-Gallardo K., Quintero-Rincon P., Olivero-Verbel J. (2025). Aromatherapy and essential oils: Holistic strategies in complementary and alternative medicine for integral wellbeing. 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