{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T14:24:51Z","timestamp":1787408691753,"version":"build-2736575974"},"reference-count":57,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP23K16260"],"award-info":[{"award-number":["JP23K16260"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Biological Research For Nursing"],"abstract":"<jats:p>\n                    Population aging has made the maintenance of cognitive function and mental health in older adults a major public health priority. Brain-derived neurotrophic factor (BDNF) and S100 calcium-binding protein B (S100\u00a0B) are biomarkers of brain health, reflecting neurotrophic support and neuroinflammatory activity, respectively. The objectives of this study were to examine the association (a) between serum BDNF and S100\u00a0B levels and (b) between these biomarkers and cognitive function and depression in community-dwelling older adults. This cross-sectional study included 95 community-dwelling adults aged \u226565\u00a0years living in rural Japan. Serum BDNF and S100\u00a0B levels were measured using enzyme-linked immunosorbent assays. Cognitive function and depressive symptoms were assessed using four instruments. Spearman\u2019s correlation analyses examined associations between the biomarkers and neuropsychological measures. Multiple regression analyses were performed using log10-transformed S100\u00a0B as the dependent variable and log10-transformed BDNF, age, sex, education, and BMI as independent variables. Serum BDNF levels were negatively correlated with serum S100\u00a0B levels (\u03b2 = \u22120.509,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt; 0.0001). This association remained significant across adjusted models (all\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt; 0.0001). Sensitivity analyses yielded consistent results. No associations were observed between serum BDNF or S100\u00a0B levels and cognitive function or depression. The inverse relationship between BDNF and S100\u00a0B suggests a link between neurotrophic and neuroinflammatory processes. Nursing interventions that enhance BDNF may also affect S100\u00a0B level, which may foster brain health in older adults.\n                  <\/jats:p>","DOI":"10.1177\/10998004261479322","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T01:33:00Z","timestamp":1787275980000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Serum BDNF and S100\u00a0B Levels in Community-Dwelling Older Adults"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6723-1474","authenticated-orcid":false,"given":"Ryuzo","family":"Orihashi","sequence":"first","affiliation":[{"name":"Saga University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takumi","family":"Shiraishi","sequence":"additional","affiliation":[{"name":"Saga University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Murakawa-Hirachi","sequence":"additional","affiliation":[{"name":"Saga University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Tateishi","sequence":"additional","affiliation":[{"name":"Saga University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Kunitake","sequence":"additional","affiliation":[{"name":"Saga University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Kunitake","sequence":"additional","affiliation":[{"name":"Saga University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshito","family":"Mizoguchi","sequence":"additional","affiliation":[{"name":"Saga University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,20]]},"reference":[{"key":"e_1_3_6_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17176056"},{"key":"e_1_3_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70444"},{"key":"e_1_3_6_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1757-7241-21-52"},{"key":"e_1_3_6_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567205018666210119145104"},{"key":"e_1_3_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2010.07.028"},{"key":"e_1_3_6_7_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867323666160406121117"},{"key":"e_1_3_6_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/nursrep15050151"},{"key":"e_1_3_6_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/01616412.2025.2529560"},{"key":"e_1_3_6_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.11.1621"},{"key":"e_1_3_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2012.05.003"},{"key":"e_1_3_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_3_6_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom15081125"},{"key":"e_1_3_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2013.10"},{"key":"e_1_3_6_15_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.140.6.566"},{"issue":"5","key":"e_1_3_6_16_1","first-page":"395","article-title":"[Analysis of reference values of serum S100B concentrations of Japanese adults]","volume":"53","author":"Ikeda Y.","year":"2005","unstructured":"Ikeda Y., Umemura K. 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