{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:35:24Z","timestamp":1792787724985,"version":"4.5.0"},"reference-count":29,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"T32 Targeted Research and Academic Training Program for Nurses in Genomics","award":["T32NR009759"],"award-info":[{"award-number":["T32NR009759"]}]},{"name":"Rockefeller University Heilbrunn Family Center for Research Nursing","id":[{"id":"https:\/\/ror.org\/0420db125","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translation Sciences","doi-asserted-by":"publisher","award":["UL1TR001866"],"award-info":[{"award-number":["UL1TR001866"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA196762"],"award-info":[{"award-number":["R01CA196762"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA221882"],"award-info":[{"award-number":["R01CA221882"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Biological Research For Nursing"],"abstract":"<jats:p>\n                    Cognitive symptoms are common in postmenopausal women treated for breast cancer (BC). In general and in BC, the Apolipoprotein E 4 allele (\n                    <jats:italic toggle=\"yes\">APOE4)<\/jats:italic>\n                    is linked to lower cognition and accelerated cognitive decline, but exercise generally benefits cognition. The purpose of this study was to examine whether the effect of aerobic exercise on cognitive function differs by\n                    <jats:italic toggle=\"yes\">APOE4<\/jats:italic>\n                    carriage in postmenopausal women with breast cancer. Longitudinal analysis of a 6-month randomized clinical trial of aerobic exercise in postmenopausal women with BC (2016\u20132022) was done. Subsample with\n                    <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                    genotype and cognitive function data (before randomization and at intervention completion) were analyzed. Variables included group assignment (Control\/Exercise),\n                    <jats:italic toggle=\"yes\">APOE4<\/jats:italic>\n                    carriage (No\/Yes), and composite scores for 7 cognitive domains (Higher = better). Robust regression was used, adjusting for age, education, baseline cognitive score, and days on endocrine therapy, with group \u00d7\n                    <jats:italic toggle=\"yes\">APOE4<\/jats:italic>\n                    carrier interaction term. In this sample (n = 116, x\u0305 = 62\u00a0years old, 21%\n                    <jats:italic toggle=\"yes\">APOE4<\/jats:italic>\n                    carriage),\n                    <jats:italic toggle=\"yes\">APOE4<\/jats:italic>\n                    carriage moderated the effect of aerobic exercise on learning and memory (b = \u22120.544,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    = 0.023). Non-carriers\u2019 scores improved and\n                    <jats:italic toggle=\"yes\">APOE4<\/jats:italic>\n                    carriers\u2019 scores declined. There were no other significant findings for attention, executive function, mental flexibility, processing speed, verbal memory, or working memory. In this hypothesis-generating study, aerobic exercise was associated with modest cognitive performance improvements in non-carriers, while\n                    <jats:italic toggle=\"yes\">APOE4<\/jats:italic>\n                    carriers did not demonstrate similar improvements. These exploratory findings suggest that a differing response for effects of exercise on cognition in post-menopausal women with BC may exist and be partially explained by\n                    <jats:italic toggle=\"yes\">APOE4<\/jats:italic>\n                    carriage.\n                  <\/jats:p>","DOI":"10.1177\/10998004261492732","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T17:47:58Z","timestamp":1791481678000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>APOE<\/i>\n                    Genotype\u2013specific Cognitive Response to Aerobic Exercise in Postmenopausal Women with Breast Cancer"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7830-8756","authenticated-orcid":false,"given":"Emily K.","family":"Mewborn","sequence":"first","affiliation":[{"name":"University of Pittsburgh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conleigh","family":"Norton","sequence":"additional","affiliation":[{"name":"University of Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2848-2200","authenticated-orcid":false,"given":"Myeong-ga","family":"Cho","sequence":"additional","affiliation":[{"name":"University of Pittsburgh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirk I.","family":"Erickson","sequence":"additional","affiliation":[{"name":"AdventHealth Research Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine M.","family":"Bender","sequence":"additional","affiliation":[{"name":"University of Pittsburgh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1784-6067","authenticated-orcid":false,"given":"Yvette P.","family":"Conley","sequence":"additional","affiliation":[{"name":"University of Pittsburgh"},{"name":"University of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,10,8]]},"reference":[{"key":"e_1_3_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11764-022-01267-z"},{"issue":"8","key":"e_1_3_8_3_1","first-page":"e43595","article-title":"The effect of physical activity on sleep quality and sleep disorder: A systematic review","volume":"15","author":"Alnawwar M. A.","year":"2023","unstructured":"Alnawwar M. A., Alraddadi M. I., Algethmi R. A., Salem G. A., Salem M. A., Alharbi A. A. (2023). The effect of physical activity on sleep quality and sleep disorder: A systematic review. Cureus, 15(8), Article e43595. https:\/\/doi.org\/10.7759\/cureus.43595","journal-title":"Cureus"},{"key":"e_1_3_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.6298"},{"key":"e_1_3_8_5_1","doi-asserted-by":"publisher","DOI":"10.1590\/1414-431x202010098"},{"key":"e_1_3_8_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40798-025-00857-2"},{"key":"e_1_3_8_7_1","doi-asserted-by":"publisher","DOI":"10.1249\/01.mss.0000239399.85955.5e"},{"key":"e_1_3_8_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11061765"},{"key":"e_1_3_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2022.101591"},{"key":"e_1_3_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2018.02.012"},{"key":"e_1_3_8_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2023.1102526"},{"key":"e_1_3_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trci.2019.02.007"},{"key":"e_1_3_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12282-023-01484-z"},{"key":"e_1_3_8_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-022-01530-2"},{"key":"e_1_3_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2012.263"},{"key":"e_1_3_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12699"},{"key":"e_1_3_8_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2018.00509"},{"key":"e_1_3_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29393"},{"key":"e_1_3_8_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/10998004251385243"},{"key":"e_1_3_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsams.2024.10.011"},{"issue":"2018","key":"e_1_3_8_21_1","first-page":"103","article-title":"APOE genotype and cognition in healthy individuals at risk of Alzheimer\u2019s disease: A review","volume":"104","author":"O\u2019Donoghue M. 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Cortex, Special Section: The Body and Cognition: The Relation between Body Representations and Higher Level Cognitive and Social Processes, 104(2018), 103\u2013123. https:\/\/doi.org\/10.1016\/j.cortex.2018.03.025","journal-title":"Cortex, Special Section: The Body and Cognition: The Relation between Body Representations and Higher Level Cognitive and Social Processes"},{"key":"e_1_3_8_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.815439"},{"key":"e_1_3_8_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-022-00574-4"},{"key":"e_1_3_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(20)30412-9"},{"key":"e_1_3_8_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-024-08696-4"},{"key":"e_1_3_8_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2016.00626"},{"key":"e_1_3_8_27_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/1947928"},{"key":"e_1_3_8_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X221133861"},{"key":"e_1_3_8_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2022.907637"},{"key":"e_1_3_8_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-025-01806-7"}],"container-title":["Biological Research For Nursing"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10998004261492732","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10998004261492732","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10998004261492732","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T16:54:12Z","timestamp":1791737652000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10998004261492732"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,8]]},"references-count":29,"alternative-id":["10.1177\/10998004261492732"],"URL":"https:\/\/doi.org\/10.1177\/10998004261492732","relation":{},"ISSN":["1099-8004","1552-4175"],"issn-type":[{"value":"1099-8004","type":"print"},{"value":"1552-4175","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,8]]},"article-number":"10998004261492732"}}