{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:09:28Z","timestamp":1777579768075,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2001,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>We aimed to discuss the possible role of developmental embryologic factors in neural crest cells in the aetiology of keratoconus and Fuchs' heterochromic iridocyclitis by presenting this case.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Report<\/jats:title>\n                    <jats:p>We diagnosed bilateral keratoconus and unilateral Fuchs' heterochromic iridocyclitis in a 19 year old women complaining of progressively blurring vision in her left eye. We also examined most of her first and second degree relatives. One niece had FHI in addition to a choroidal nevus in the inferior temporal quadrant of her left eye.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Regarding the common embryological origins of iris stroma, uveal melanocytes and corneal stroma, it might be worth considering that the combination of FHI and keratoconus is not coincidental. A role of embryologic factors in neural crest cells in the etiology of both diseases cannot be excluded.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/112067210101100114","type":"journal-article","created":{"date-parts":[[2018,1,19]],"date-time":"2018-01-19T00:34:42Z","timestamp":1516322082000},"page":"73-76","source":"Crossref","is-referenced-by-count":1,"title":["Keratoconus and Fuchs' Heterochromic Iridocyclitis: A Coincidence or a Defect during Embryogenesis?"],"prefix":"10.1177","volume":"11","author":[{"given":"A.","family":"Yagci","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Ege University Faculty of Medicine, Izmir"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Uretmen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ege University Faculty of Medicine, Izmir"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Egrilmez","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ege University Faculty of Medicine, Izmir"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"Gunenc","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, 9 Eylul University Faculty of Medicine, Izmir"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Kusbeci","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Gediz State Hospital, Kutahya - Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2001,1,1]]},"reference":[{"key":"bibr1-112067210101100114","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.78.4.307"},{"key":"bibr2-112067210101100114","doi-asserted-by":"publisher","DOI":"10.1016\/0039-6257(84)90094-8"},{"key":"bibr3-112067210101100114","first-page":"191","volume":"15","author":"Fuchs E.","year":"1906","journal-title":"Z Augenheilkd"},{"key":"bibr4-112067210101100114","first-page":"437","volume":"63","author":"De Rosa C.","year":"1959","journal-title":"Arch Ophthalmol"},{"key":"bibr5-112067210101100114","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.77.7.455"},{"key":"bibr6-112067210101100114","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1992.01080180078032"},{"key":"bibr7-112067210101100114","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)72322-0"},{"key":"bibr8-112067210101100114","doi-asserted-by":"publisher","DOI":"10.1016\/0039-6257(93)90009-V"},{"key":"bibr9-112067210101100114","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)74604-5"},{"key":"bibr10-112067210101100114","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)75757-5"},{"key":"bibr11-112067210101100114","doi-asserted-by":"publisher","DOI":"10.3109\/02713689008999420"},{"key":"bibr12-112067210101100114","first-page":"917","volume":"31","author":"Murray P.I.","year":"1990","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bibr13-112067210101100114","doi-asserted-by":"publisher","DOI":"10.1076\/ocii.7.2.75.4017"},{"key":"bibr14-112067210101100114","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.1999.00921.x"},{"key":"bibr15-112067210101100114","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.1998.00428.x"},{"key":"bibr16-112067210101100114","first-page":"367","volume-title":"Principles and Practice of Ophthalmology 1st edition.","author":"Ralph C.","year":"1994"},{"key":"bibr17-112067210101100114","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(63)91645-3"},{"key":"bibr18-112067210101100114","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(58)90403-3"},{"key":"bibr19-112067210101100114","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-199205000-00012"},{"key":"bibr20-112067210101100114","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-199401000-00013"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/112067210101100114","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/112067210101100114","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:38:28Z","timestamp":1777405108000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/112067210101100114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,1]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2001,1]]}},"alternative-id":["10.1177\/112067210101100114"],"URL":"https:\/\/doi.org\/10.1177\/112067210101100114","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,1]]}}}