{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:22:51Z","timestamp":1791246171633,"version":"4.1.0"},"reference-count":22,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2002,3,1]],"date-time":"2002-03-01T00:00:00Z","timestamp":1014940800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2002,3]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To look for ophthalmologic abnormalities in 15 patients with Wolfram syndrome, also known as DIDMOAD syndrome (diabetes insipidus, diabetes mellitus, optic atrophy and deafness).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fifteen patients from four inbred families diagnosed as having Wolfram syndrome at the National Center for Diabetes, Endocrinology and Genetics, in Amman, Jordan, were evaluated ophthalmologically. Their examination included best-corrected visual acuity, color vision testing, pupillary light reflexes, slit-lamp biomicroscopy and fundus examination. Fundus fluorescein angiography was done in all patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The prevalence of optic atrophy was (93.3%), color defect (92.9%), cataract (66.6%), pigmentary retinopathy (30%) and diabetic retinopathy (20%). Abnormal pupillary light reflexes and nystagmus were also reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Although our group of patients was genetically heterogeneous, the ophthalmic findings are consistent with those reported in other series, except for cataract which was highly prevalent but mild and did not contribute significantly to loss of vision. (Eur J Ophthalmol 2002; 12: 84\u20138)<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/112067210201200202","type":"journal-article","created":{"date-parts":[[2018,1,19]],"date-time":"2018-01-19T00:31:21Z","timestamp":1516321881000},"page":"84-88","source":"Crossref","is-referenced-by-count":58,"title":["Ophthalmologic Findings in Fifteen Patients with Wolfram Syndrome"],"prefix":"10.1177","volume":"12","author":[{"given":"M.","family":"Al-Till","sequence":"first","affiliation":[{"name":"Ophthalmology Department, Jordan University Hospital, Amman"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.S.","family":"Jarrah","sequence":"additional","affiliation":[{"name":"National Center for Diabetes, Endocrinology and Genetics, Amman - Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.M.","family":"Ajlouni","sequence":"additional","affiliation":[{"name":"National Center for Diabetes, Endocrinology and Genetics, Amman - Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2002,3,1]]},"reference":[{"key":"bibr1-112067210201200202","first-page":"715","volume":"13","author":"Wolfram D.J.","year":"1938","journal-title":"Mayo Clin Proc"},{"key":"bibr2-112067210201200202","first-page":"385","volume":"35","author":"Rose F.C.","year":"1966","journal-title":"Q J Med"},{"key":"bibr3-112067210201200202","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1977.tb15069.x"},{"key":"bibr4-112067210201200202","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)92157-D"},{"key":"bibr5-112067210201200202","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1991.tb11908.x"},{"key":"bibr6-112067210201200202","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.34.10.838"},{"key":"bibr7-112067210201200202","first-page":"505","volume":"45","author":"Page M.","year":"1976","journal-title":"Q J Med"},{"key":"bibr8-112067210201200202","doi-asserted-by":"publisher","DOI":"10.1038\/ng0994-95"},{"key":"bibr9-112067210201200202","first-page":"963","volume":"58","author":"Barrientos A.","year":"1996","journal-title":"Am J Hum Genet"},{"key":"bibr10-112067210201200202","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118581"},{"key":"bibr11-112067210201200202","first-page":"855","volume":"59","author":"Collier D.A.","year":"1996","journal-title":"Am J Hum Genet"},{"key":"bibr12-112067210201200202","doi-asserted-by":"publisher","DOI":"10.1086\/302858"},{"key":"bibr13-112067210201200202","doi-asserted-by":"publisher","DOI":"10.5144\/0256-4947.1999.132"},{"key":"bibr14-112067210201200202","doi-asserted-by":"publisher","DOI":"10.1038\/eye.1997.226"},{"key":"bibr15-112067210201200202","first-page":"734","volume":"21","author":"Hajji Z.","year":"1998","journal-title":"J Fr Ophtalmol"},{"key":"bibr16-112067210201200202","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410390312"},{"key":"bibr17-112067210201200202","first-page":"75","volume":"252","author":"Seynaeve H.","year":"1994","journal-title":"Bull Soc Belge Ophthalmol"},{"key":"bibr18-112067210201200202","first-page":"235","volume":"37","author":"Okten A.","year":"1995","journal-title":"Turk J Pediatr"},{"key":"bibr19-112067210201200202","doi-asserted-by":"publisher","DOI":"10.1007\/BF01720362"},{"key":"bibr20-112067210201200202","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0420.1998.760223.x"},{"key":"bibr21-112067210201200202","doi-asserted-by":"publisher","DOI":"10.1038\/eye.1993.60"},{"key":"bibr22-112067210201200202","first-page":"223","volume":"4","author":"Dahbour S.","year":"1999","journal-title":"Annu Rev Neurosci"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/112067210201200202","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/112067210201200202","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:38:47Z","timestamp":1777405127000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/112067210201200202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,3]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2002,3]]}},"alternative-id":["10.1177\/112067210201200202"],"URL":"https:\/\/doi.org\/10.1177\/112067210201200202","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,3]]}}}