{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T11:24:42Z","timestamp":1788175482772,"version":"build-2803163510"},"reference-count":19,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2002,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the effect on lacrimal function and ocular complications in patients with severe acne vulgaris during systemic treatment with 13- cis -retinoic acid (isotretinoin).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Forty patients with acne vulgaris were treated with systemic isotretinoin at dosages of 0.5-1 mg\/kg per day for two months. Full ophthalmologic examination, Schirmer \/ test, fluorescein break-up (BUT) and microbiological investigations of the conjunctival flora were done before, during the second month and at least one month after the end of the treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The average Schirmer values before and after the treatment were 21.6 mm\/5 minutes (SD \u00b1 7.01) and 18.48 mm\/5 minutes (SD \u00b1 7.87) respectively. After the treatment BUT was less than 10 seconds in 50% of the patients and 55% had blepharitis. Subjective symptoms like dryness, itching and contact lens intolerance occurred in 42.5% and colonization of the conjunctiva by Staphylococcus aureus increased significantly during treatment (p = 0.031). All abnormal findings disappeared one month after the cessation of treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Isotretinoin causes signs and symptoms of dry eye, probably by reducing meibomian gland function, but ocular complications are generally not serious when low doses are used for a limited time, and are reversible after discontinuation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/112067210201200316","type":"journal-article","created":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T06:57:27Z","timestamp":1623394647000},"page":"173-176","source":"Crossref","is-referenced-by-count":45,"title":["Lacrimal Function and Ocular Complications in Patients Treated with                     Systemic Isotretinoin"],"prefix":"10.1177","volume":"12","author":[{"given":"B.","family":"Bozkurt","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Ankara -\r                Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.T.","family":"\u00cdRke\u00e7","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ankara -\r                Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Atakan","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Ankara -\r                Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Orhan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ankara -\r                Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.\u00d6.","family":"Geyik","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Hacettepe\r                University School of Medicine, Ankara - Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2002,1,1]]},"reference":[{"key":"bibr1-112067210201200316","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199753030-00003"},{"key":"bibr2-112067210201200316","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(90)90034-X"},{"key":"bibr3-112067210201200316","doi-asserted-by":"publisher","DOI":"10.1007\/BF00509064"},{"key":"bibr4-112067210201200316","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(85)90676-2"},{"key":"bibr5-112067210201200316","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1982.tb00410.x"},{"key":"bibr6-112067210201200316","doi-asserted-by":"publisher","DOI":"10.1007\/BF00406424"},{"key":"bibr7-112067210201200316","first-page":"660","volume":"22","author":"Jester J.V.","year":"1982","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bibr8-112067210201200316","first-page":"1559","volume":"29","author":"Lambert R.W.","year":"1988","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bibr9-112067210201200316","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1983.tb01068.x"},{"key":"bibr10-112067210201200316","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0420.1995.tb00043.x"},{"key":"bibr11-112067210201200316","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(79)35468-9"},{"key":"bibr12-112067210201200316","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1987.01060030136044"},{"key":"bibr13-112067210201200316","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-199107000-00002"},{"key":"bibr14-112067210201200316","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12285658"},{"key":"bibr15-112067210201200316","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1987.01660290074019"},{"key":"bibr16-112067210201200316","first-page":"182","volume":"117","author":"Weiss J.","year":"1981","journal-title":"Arch Ophthalmol"},{"key":"bibr17-112067210201200316","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-200003000-00020"},{"key":"bibr18-112067210201200316","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1986.01050180065031"},{"key":"bibr19-112067210201200316","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1986.01050130079024"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/112067210201200316","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/112067210201200316","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:38:52Z","timestamp":1777405132000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/112067210201200316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,1]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2002,1]]}},"alternative-id":["10.1177\/112067210201200316"],"URL":"https:\/\/doi.org\/10.1177\/112067210201200316","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,1]]}}}