{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T19:55:36Z","timestamp":1777578936289,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2005,5,1]],"date-time":"2005-05-01T00:00:00Z","timestamp":1114905600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2005,5]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To test the ability of structural parameters (as measured by scanning laser polarimetry (SLP) software 1.0.12 and confocal scanning laser ophthalmoscopy (CSLO) to discriminate between normal and glaucomatous eyes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 112 patients with primary open-angle glaucoma and 88 normal individuals were enrolled in the study. All individuals underwent a thorough ophthalmic evaluation, a 24\u20132 full threshold Humphrey visual field, SLP with the GDx, and CSLO with the TOPSS. Patients with marked cataract or low vision were excluded from the study. Cut-off points were selected and receiver operator characteristic (ROC) curves were created for each individual CSLO and SLP parameter. Finally, multivariate discriminant formulas were developed in order to achieve a better sensitivity (Se)\/specificity (Sp) ratio for the diagnosis of glaucoma, initially separately for each device, and then combining parameters from CSLO and SLP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The mean deviation for the glaucoma group was \u221210.63 \u00b17.58 dB. Multivariate discriminant formulas resulted in better sensitivity\/specificity ratios than any individual parameter, either for CSLO (Se: 90%; Sp: 81%; accuracy: 86%) or SLP (Se: 87%; Sp: 86%; accuracy: 86%). The multivariate formula combining parameters from both devices resulted in an improvement in the ability to diagnose glaucoma. An area under the ROC curve of 0.97 was obtained, with a sensitivity of 93%, a specificity of 91 %, and an accuracy of 92%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The combination of structural parameters derived from CSLO and SLP in a multivariate discriminant formula may enhance the ability to diagnose glaucoma. Further studies investigating a random population are needed in order to test the validity of this formula.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/112067210501500307","type":"journal-article","created":{"date-parts":[[2018,1,19]],"date-time":"2018-01-19T00:46:32Z","timestamp":1516322792000},"page":"353-359","source":"Crossref","is-referenced-by-count":2,"title":["Discrimination between Normal and Glaucomatous Eyes with Scanning Laser Polarimetry and Optic Disc Topography: A Preliminary Report"],"prefix":"10.1177","volume":"15","author":[{"given":"L.","family":"Magacho","sequence":"first","affiliation":[{"name":"University of Campinas, Campinas"},{"name":"Federal University of Goi\u00e1s, Goi\u00e2nia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.M.","family":"Marcondes","sequence":"additional","affiliation":[{"name":"University of Campinas, Campinas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.P.","family":"Costa","sequence":"additional","affiliation":[{"name":"University of Campinas, Campinas"},{"name":"University of S\u00e3o Paulo, S\u00e3o Paulo - Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2005,5,1]]},"reference":[{"key":"bibr1-112067210501500307","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.83.6.664"},{"key":"bibr2-112067210501500307","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1989.01070010540027"},{"key":"bibr3-112067210501500307","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1979.01020020106002"},{"key":"bibr4-112067210501500307","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1991.01080010079037"},{"key":"bibr5-112067210501500307","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(92)32018-4"},{"key":"bibr6-112067210501500307","first-page":"741","volume":"41","author":"Kerrigan-Baumrind L.A.","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bibr7-112067210501500307","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)70221-1"},{"key":"bibr8-112067210501500307","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.116.12.1583"},{"key":"bibr9-112067210501500307","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.84.8.852"},{"key":"bibr10-112067210501500307","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.82.1.14"},{"key":"bibr11-112067210501500307","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(98)98047-2"},{"key":"bibr12-112067210501500307","doi-asserted-by":"publisher","DOI":"10.1097\/00061198-199508000-00005"},{"key":"bibr13-112067210501500307","first-page":"736","volume":"31","author":"Jonas J.B.","year":"1990","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bibr14-112067210501500307","first-page":"1151","volume":"29","author":"Jonas J.B.","year":"1988","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bibr15-112067210501500307","first-page":"153","volume":"33","author":"Caprioli J.","year":"1992","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bibr16-112067210501500307","volume-title":"Automated Static Perimetry.","author":"Anderson D.R.","year":"1999"},{"key":"bibr17-112067210501500307","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1993.01090060119035"},{"key":"bibr18-112067210501500307","volume-title":"Clinical Decisions in Glaucoma.","author":"Hodapp E.","year":"1993"},{"key":"bibr19-112067210501500307","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1982.01030030137016"},{"key":"bibr20-112067210501500307","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.85.5.586"},{"key":"bibr21-112067210501500307","doi-asserted-by":"publisher","DOI":"10.1007\/BF02172962"},{"key":"bibr22-112067210501500307","doi-asserted-by":"publisher","DOI":"10.1097\/00061198-199804000-00010"},{"key":"bibr23-112067210501500307","first-page":"140","volume":"43","author":"Greaney M.J.","year":"2002","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bibr24-112067210501500307","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.82.9.986"},{"key":"bibr25-112067210501500307","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)70632-4"},{"key":"bibr26-112067210501500307","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.119.7.985"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/112067210501500307","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/112067210501500307","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:36:10Z","timestamp":1777404970000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/112067210501500307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,5]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,5]]}},"alternative-id":["10.1177\/112067210501500307"],"URL":"https:\/\/doi.org\/10.1177\/112067210501500307","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,5]]}}}