{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T19:57:26Z","timestamp":1777579046671,"version":"3.51.4"},"reference-count":38,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2006,3]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      To prospectively evaluate the effects of 2% hydroxypropyl-methylcellulose (HPMC-Ophtal\n                      <jats:sup>\u00ae<\/jats:sup>\n                      ) and sodium hyaluronate 1% (Ophthalin\n                      <jats:sup>\u00ae<\/jats:sup>\n                      ) on intraocular pressure, corneal thickness, and endothelial cell loss in small incision cataract surgery with implant. METHODS. A total of 110 patients undergoing routine phacoemulsification with implant received either 2% hydroxypropylmethylcellulose or sodium hyaluronate 1% as ophthalmic viscosurgical device. Pre- and postoperative slit lamp examination, intraocular pressure measurement (preoperatively and at 1\u20134 hours, 1 day, and 7 days postoperatively), ultrasonic pachymetry (preoperatively and at 1 week, 4\u20136 weeks, and 12 weeks postoperatively), and corneal endothelial cell count (preoperatively and 12 weeks postoperatively) were performed. Data were analyzed using two-way analysis of variance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      All measurements were comparable between the two groups preoperatively. Intraocular pressure was significantly lower in the Ophthalin\n                      <jats:sup>\u00ae<\/jats:sup>\n                      group at 1 day postoperatively, while no significant difference was found between the two groups on the 1\u20134 hours and 7 days examination. The central corneal thickness was not significantly different between the two groups at any postoperative visit. However, the mean cell density demonstrated a significant fall of 11.76% for Ophthalin\n                      <jats:sup>\u00ae<\/jats:sup>\n                      and 4.27% for HPMC-Ophtal\n                      <jats:sup>\u00ae<\/jats:sup>\n                      at 12 weeks postoperatively, the difference between the two being significant (p=0.009).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>2% Hydroxypropylmethylcellulose, compared with sodium hyaluronate 1%, is superior in protecting the corneal endothelial cells, has the same effect on central corneal thickness, and is associated with slightly higher intraocular pressure 1 day postoperatively. It compares favorably with sodium hyaluronate 1% and can be used as an effective and cheaper alternative in routine small incision cataract surgery with implant.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/112067210601600208","type":"journal-article","created":{"date-parts":[[2018,1,19]],"date-time":"2018-01-19T00:48:42Z","timestamp":1516322922000},"page":"239-246","source":"Crossref","is-referenced-by-count":10,"title":["Comparison of the Effect of Sodium Hyaluronate (Ophthalin\n                    <sup>\u00ae<\/sup>\n                    ) and Hydroxypropylmethylcellulose (HPMC-Ophtal\n                    <sup>\u00ae<\/sup>\n                    ) on Corneal Endothelium, Central Corneal Thickness, and Intraocular Pressure after Phacoemulsification"],"prefix":"10.1177","volume":"16","author":[{"given":"N.","family":"Ray-Chaudhuri","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Royal Victoria Infirmary, University of Newcastle upon Tyne, Newcastle upon Tyne - United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.M.","family":"Voros","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Royal Victoria Infirmary, University of Newcastle upon Tyne, Newcastle upon Tyne - United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Sutherland","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Royal Victoria Infirmary, University of Newcastle upon Tyne, Newcastle upon Tyne - United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.C.","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Royal Victoria Infirmary, University of Newcastle upon Tyne, Newcastle upon Tyne - United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2006,3,1]]},"reference":[{"key":"bibr1-112067210601600208","first-page":"1972","volume":"30","author":"Hirst L.W.","year":"1989","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bibr2-112067210601600208","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(82)90693-6"},{"key":"bibr3-112067210601600208","doi-asserted-by":"publisher","DOI":"10.1016\/S0146-2776(78)80007-X"},{"key":"bibr4-112067210601600208","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1970.00990040743008"},{"key":"bibr5-112067210601600208","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(76)90663-2"},{"key":"bibr6-112067210601600208","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(13)80341-0"},{"key":"bibr7-112067210601600208","doi-asserted-by":"publisher","DOI":"10.1016\/0039-6257(90)90027-S"},{"key":"bibr8-112067210601600208","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(02)01745-5"},{"key":"bibr9-112067210601600208","first-page":"1329","volume":"25","author":"Hammer M.E.","year":"1984","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bibr10-112067210601600208","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1991.01080100118055"},{"key":"bibr11-112067210601600208","doi-asserted-by":"publisher","DOI":"10.1177\/112067210301300209"},{"key":"bibr12-112067210601600208","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.67.4.259"},{"key":"bibr13-112067210601600208","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.1991.tb01993.x"},{"key":"bibr14-112067210601600208","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(02)01891-6"},{"key":"bibr15-112067210601600208","unstructured":"WenzelM., OhrloffC., DunckerG. 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