{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T19:58:24Z","timestamp":1777579104057,"version":"3.51.4"},"reference-count":11,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T00:00:00Z","timestamp":1146441600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To report two cases of bilateral retinoblastoma (RB) with unusual presentations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The medical records of 321 patients from the Retinoblastoma Referral Center in Siena were reviewed. A total of 111 patients had bilateral RB, 2 of them presenting with phthisis bulbi and buphthalmos. Both patients underwent bilateral enucleation. Clinical features, imaging studies, and histopathology were reviewed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>These 2 cases represent 0.62% (2\/321) in our series. Histopathology did not reveal viable tumor cells in the phthisical eyes; in both buphthalmic eyes the tumor was active, infiltrating the choroid and optic nerve.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Phthisis bulbi and buphthalmos are unusual presenting signs of RB. This very rare combination of these two signs in different eyes of the same patient is probably due to a delay in diagnosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/112067210601600318","type":"journal-article","created":{"date-parts":[[2018,1,19]],"date-time":"2018-01-19T00:43:53Z","timestamp":1516322633000},"page":"465-469","source":"Crossref","is-referenced-by-count":9,"title":["Phthisis Bulbi and Buphthalmos as Presenting Signs of Retinoblastoma: A Report of Two Cases and Literature Review"],"prefix":"10.1177","volume":"16","author":[{"given":"T.","family":"Hadjistilianou","sequence":"first","affiliation":[{"name":"Retinoblastoma Referral Center, Department of Ophthalmologycal Sciences, University of Siena, Siena - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"De Francesco","sequence":"additional","affiliation":[{"name":"Retinoblastoma Referral Center, Department of Ophthalmologycal Sciences, University of Siena, Siena - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Marconcini","sequence":"additional","affiliation":[{"name":"Departments of Ophthalmology, Pediatrics, Obstetrics, and Reproductive Medicine, University of Siena, Siena - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Mastrangelo","sequence":"additional","affiliation":[{"name":"Retinoblastoma Referral Center, Department of Ophthalmologycal Sciences, University of Siena, Siena - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Galluzzi","sequence":"additional","affiliation":[{"name":"Departments of Human Pathology and Oncology, University of Siena, Siena - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Toti","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Azienda Ospedaliera e Universitaria Senese, University of Siena, Siena - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2006,5,1]]},"reference":[{"key":"bibr1-112067210601600318","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(98)70028-9"},{"key":"bibr2-112067210601600318","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1035546"},{"key":"bibr3-112067210601600318","doi-asserted-by":"publisher","DOI":"10.1038\/eye.1997.85"},{"key":"bibr4-112067210601600318","doi-asserted-by":"publisher","DOI":"10.1067\/mpa.2002.120643"},{"key":"bibr5-112067210601600318","doi-asserted-by":"publisher","DOI":"10.1097\/00004397-196206000-00015"},{"key":"bibr6-112067210601600318","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(61)90164-7"},{"key":"bibr7-112067210601600318","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(77)80003-9"},{"key":"bibr8-112067210601600318","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-197001000-00002"},{"key":"bibr9-112067210601600318","doi-asserted-by":"publisher","DOI":"10.3928\/0191-3913-20030501-11"},{"key":"bibr10-112067210601600318","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-200212000-00004"},{"key":"bibr11-112067210601600318","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)76255-5"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/112067210601600318","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/112067210601600318","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:36:42Z","timestamp":1777405002000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/112067210601600318"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5]]},"references-count":11,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["10.1177\/112067210601600318"],"URL":"https:\/\/doi.org\/10.1177\/112067210601600318","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,5]]}}}