{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T19:58:20Z","timestamp":1777579100183,"version":"3.51.4"},"reference-count":13,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T00:00:00Z","timestamp":1146441600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Vernal keratoconjunctivitis (VKC) is a severe, chronic allergic inflammatory disease of the ocular surface poorly responsive to antiallergic treatments and possibly leading to permanent visual impairment. VKC, because of mast cell, eosinophil, and Th2-type inflammation, polyclonal IgE activation, and tissue remodeling, is considered to be a typical Th2-driven disease. Viral infection stimulates a Th1 type immune response, potentially attenuating allergen-induced inflammation. The purpose of this report is to describe the effect of viral keratoconjunctivitis in a patient with VKC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The authors report on a patient with a severe form of VKC, poorly responsive to antiallergic treatments, who developed a viral keratoconjunctivitis. Signs, symptoms, and cytologic findings were recorded during the 5-year follow-up period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The authors observed a prompt and permanent improvement of signs and symptoms of the allergic condition after the viral infection. Conjunctival scraping confirms that the inhibition of the eosinophilic inflammation lasts at least for 5 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this case, the viral infection seemed to induce a clinical recovery of allergic disease, suggesting that an immune deviation induced by Th1-polarizing agents may revert an ongoing Th2 inflammation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/112067210601600319","type":"journal-article","created":{"date-parts":[[2018,1,19]],"date-time":"2018-01-19T00:43:53Z","timestamp":1516322633000},"page":"470-472","source":"Crossref","is-referenced-by-count":6,"title":["Allergy and Infections: Long-Term Improvement of Vernal Keratoconjunctivitis following Viral Conjunctivitis"],"prefix":"10.1177","volume":"16","author":[{"given":"R.","family":"Sgrulletta","sequence":"first","affiliation":[{"name":"Interdisciplinary Center for Biomedical Research (CIR), Laboratory of Ophthalmology, University of Roma \u201cCampus Bio-Medico\u201d"},{"name":"G.B. Bietti Eye Foundation, IRCCS"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Bonini","sequence":"additional","affiliation":[{"name":"Interdisciplinary Center for Biomedical Research (CIR), Laboratory of Ophthalmology, University of Roma \u201cCampus Bio-Medico\u201d"},{"name":"G.B. Bietti Eye Foundation, IRCCS"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Lambiase","sequence":"additional","affiliation":[{"name":"Interdisciplinary Center for Biomedical Research (CIR), Laboratory of Ophthalmology, University of Roma \u201cCampus Bio-Medico\u201d"},{"name":"G.B. Bietti Eye Foundation, IRCCS"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Bonini","sequence":"additional","affiliation":[{"name":"Internal Medicine, Second University of Napoli and Institute of Neurobiology and Molecular Medicine, Italian National Research Council, Roma - Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2006,5,1]]},"reference":[{"key":"bibr1-112067210601600319","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(00)00092-0"},{"key":"bibr2-112067210601600319","doi-asserted-by":"publisher","DOI":"10.1016\/S1350-9462(99)00004-X"},{"key":"bibr3-112067210601600319","doi-asserted-by":"publisher","DOI":"10.1038\/ni0904-865a"},{"key":"bibr4-112067210601600319","first-page":"130","volume-title":"Basic and Clinical Science Course 2002\u20133.","author":"American Academy of Ophthalmology.","year":"2003"},{"key":"bibr5-112067210601600319","unstructured":"KanskiJ.J. Clinical Ophthalmology: A Systematic Approach. 5th ed. Ch. 4. Boston: Butterworth Heinemann; 2003: 68\u20139."},{"key":"bibr6-112067210601600319","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.4049\/jimmunol.146.4.1169","volume":"146","author":"Maggi E.","year":"1991","journal-title":"J Immunol"},{"key":"bibr7-112067210601600319","doi-asserted-by":"publisher","DOI":"10.1159\/000236942"},{"key":"bibr8-112067210601600319","doi-asserted-by":"publisher","DOI":"10.1089\/104303402760293547"},{"key":"bibr9-112067210601600319","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.1.127-135.2002"},{"key":"bibr10-112067210601600319","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(00)90080-0"},{"key":"bibr11-112067210601600319","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.86.10.1166"},{"key":"bibr12-112067210601600319","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.05-0138"},{"key":"bibr13-112067210601600319","doi-asserted-by":"publisher","DOI":"10.1186\/rr22"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/112067210601600319","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/112067210601600319","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:36:42Z","timestamp":1777405002000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/112067210601600319"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["10.1177\/112067210601600319"],"URL":"https:\/\/doi.org\/10.1177\/112067210601600319","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,5]]}}}