{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T19:58:45Z","timestamp":1777579125908,"version":"3.51.4"},"reference-count":41,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the corneal complications associated with the combined use of nonsteroid anti-inflammatory drugs (NSAIDs) and topical steroids following vitreoretinal surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHOD.<\/jats:title>\n                    <jats:p>Description of corneal lesions in three patients after vitrectomy with use of topical ketorolac and prednisolone acetate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Three eyes of three patients developed an atrophic central corneal ulcer with stromal thinning following a pars plana vitrectomy under local anesthesia. Lesions were asymptomatic and were found during a routine examination 2, 3, and 8 weeks after surgery, respectively. Surgical indications were as follows: a pre-retinal membrane, choroidal neovascularization, and massive uveal effusion following cataract surgery. Topical postoperative treatment was as follows: ketorolac 4 times a day, a combination of prednisolone acetate, polymyxin B, and neomycin 6 times a day, and 1% cyclopentolate 3 times a day. Suspension of ketorolac and ocular occlusion led to the resolution of corneal lesions between 2.5 and 3 months later, yielding a central superficial scarring, which showed no changes after a follow-up of 3 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Toxic keratolysis may appear as a secondary effect of the combined use of topical NSAIDs and steroids following vitreoretinal surgery and must be taken into account in the differential diagnosis of postoperative corneal lesions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/112067210601600413","type":"journal-article","created":{"date-parts":[[2018,1,19]],"date-time":"2018-01-19T00:46:44Z","timestamp":1516322804000},"page":"582-587","source":"Crossref","is-referenced-by-count":6,"title":["Toxic Keratolysis from Combined use of Nonsteroid Anti-Inflammatory Drugs and Topical Steroids following Vitreoretinal 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