{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T11:30:59Z","timestamp":1788348659220,"version":"build-2803163510"},"reference-count":22,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To report the changing patterns of ocular manifestations in human immunodeficiency virus (HIV) seropositive patients treated with highly active antiretroviral therapy (HAART).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The clinical charts of HIV seropositive patients, 735 examined from 1997 to 2003 and treated with HAART for at least 2 months (Group 1), and 838 untreated examined from 1988 to 1995 (Group 2), were reviewed to assess the frequency of ocular manifestations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>HIV- related retinal microangiopathy and opportunistic retinal infections (cytomegalovirus retinitis and toxoplasmic retinochoroiditis) were significantly higher in Group 2 than 1 (p&lt;0.0001), while in patients treated with HAART a statistically significant increase in the frequency of chalazion (p&lt;0.0001), diabetic and hypertensive retinopathy (p&lt;0.0001), lipid arc of the cornea (p&lt;0.0001), cataract and glaucoma (p&lt;0.0001), and uveitis (p=0.026) was observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HAART therapy has induced a dramatic decrease in the incidence of HIV-related microangiopathy and opportunistic retinal infection and the occurrence of new lesions related both to the metabolic alterations induced by HAART and to immune reconstitution, such as uveitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/112067210601600511","type":"journal-article","created":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T11:14:52Z","timestamp":1516792492000},"page":"728-732","source":"Crossref","is-referenced-by-count":24,"title":["Changing Patterns of Ocular Manifestations in HIV Seropositive Patients Treated with HAART"],"prefix":"10.1177","volume":"16","author":[{"given":"M.","family":"Accorinti","sequence":"first","affiliation":[{"name":"Servizio Speciale di Immunovirologia Oculare, Dipartimento di Scienze Oftalmologiche, Universit\u00e0 degli Studi di Roma \u201cLa Sapienza\u201d, Roma - 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