{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T09:24:41Z","timestamp":1792661081396,"version":"4.5.0"},"reference-count":6,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose.<\/jats:title>\n                    <jats:p>To describe the efficacy of MP-1 in detecting early multiple sclerosis (MS) retinal lesions and in monitoring the effectiveness of treatment in terms of changes in macular sensitivity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods.<\/jats:title>\n                    <jats:p>A 21-year-old woman with MS was referred to us complaining of recurrent episodes of eyesight loss in both eyes. At ophthalmologic examination, best-corrected visual acuity was 20\/25 bilaterally; ophthalmoscopy showed bilateral slight optic neuritis without swelling of the disc. Static perimetry of central visual field (30 degrees, by Octopus 101, Haag-Streit AG, Switzerland) and retinal sensitivity of the 12 central degrees (by MP-1 Micro Perimeter, Nidek Inc., Italy) were performed on the patient at that time. The microperimeter (MP-1) showed a loss of sensitivity in the macular region with 0.28\u00b10.9 dB sensitivity in the right eye and 19.42\u00b11.5 dB in the left. The mean fixation stability was 91% considering 2\u00b0 and 99% considering 4\u00b0 around the fixation points in the right eye, and 97% in 2\u00b0 and 100% in 4\u00b0 central degrees in the left. In the weeks that followed vision continued to get worse in both eyes, so she underwent a steroid therapy with methylprednisolone IV 1000 mg\/day for 5 days and 500 mg\/day for 3 days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results.<\/jats:title>\n                    <jats:p>After 8 days of therapy the MP-1 showed a significant recovery in the right eye, with mean light sensitivity being 19.61\u00b11.3 dB in the right eye and 20.0\u00b10 dB in the left eye in both macular and peripapillary regions. The mean fixation stability was 100% considering 2\u00b0 and 100% considering 4\u00b0 around the fixation points in both eyes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conlcusions.<\/jats:title>\n                    <jats:p>The MP-1 can be an interesting tool for neuro-ophthalmologists as it allows a more precise evaluation of the macular and peripapillary region, which is not easily studied with conventional automated perimetry. In MS, the presence of a subclinical form of optic nerve involvement can be demonstrated in a very early stage, and well followed by the introduction of microperimeter testing in the standard examination protocol.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/112067210701700330","type":"journal-article","created":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T11:15:09Z","timestamp":1516792509000},"page":"441-444","source":"Crossref","is-referenced-by-count":6,"title":["Macular Sensitivity Change in Multiple Sclerosis followed with Microperimetry"],"prefix":"10.1177","volume":"17","author":[{"given":"M.R.","family":"Romano","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, S. Sebstiano Hospital, Caserta - Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Angi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, S. Sebstiano Hospital, Caserta - Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Romano","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, S. Sebstiano Hospital, Caserta - Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2007,5,1]]},"reference":[{"key":"bibr1-112067210701700330","doi-asserted-by":"publisher","DOI":"10.1097\/01.wco.0000227032.47458.cb"},{"key":"bibr2-112067210701700330","doi-asserted-by":"publisher","DOI":"10.1097\/01.icu.0000179804.49842.e2"},{"key":"bibr3-112067210701700330","doi-asserted-by":"publisher","DOI":"10.1177\/112067210501500612"},{"key":"bibr4-112067210701700330","doi-asserted-by":"publisher","DOI":"10.4321\/S0365-66912006000400001"},{"key":"bibr5-112067210701700330","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2004.11.051"},{"key":"bibr6-112067210701700330","doi-asserted-by":"publisher","DOI":"10.1076\/ocii.10.3.161.15603"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/112067210701700330","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/112067210701700330","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:37:17Z","timestamp":1777405037000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/112067210701700330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5]]},"references-count":6,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,5]]}},"alternative-id":["10.1177\/112067210701700330"],"URL":"https:\/\/doi.org\/10.1177\/112067210701700330","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,5]]}}}