{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:04:16Z","timestamp":1777579456993,"version":"3.51.4"},"reference-count":37,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2007,11,1]],"date-time":"2007-11-01T00:00:00Z","timestamp":1193875200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Pterygium is a proliferative, inflammatory, and invasive ocular surface disease associated with excessive ultraviolet radiation exposure and has several tumor-like characteristics. Cyclooxygenase-2 (COX-2) is an inducible enzyme and recently increased expression of the enzyme was found in many cancers and premalign lesions. This study was conducted to identify the COX-2 expression in pterygium tissues.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Immunohistochemical staining using a primary antibody for COX-2 was performed on 30 specimens with primary pterygium (20 pterygium without recurrence and 10 pterygium which recurred during a 12-month follow-up), 11 specimens with recurrent pterygium, and 8 specimens of conjunctival tumor. As a control we used 10 specimens of normal conjunctiva. Extent and intensity of cytoplasmic and membranous staining in epithelial cells were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Higher expression of COX-2 was detected in conjunctival tumor (87.5%) specimens and recurrent pterygium specimens (72.7%) compared to the both normal conjunctiva (30%) and primary pterygium without recurrence (30%). COX-2 expression in primary pterygium tissues with recurrence (60%) was not different from primary pterygium without recurrence (p=0.114) and recurrent pterygium (p=0.537). However, recurrent pterygium tissues were found to express higher COX-2 than primary pterygium without recurrence (p=0.022).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>COX-2 expression is increased in recurrent pterygium tissues and COX-2 expression may be a marker for the prediction of recurrence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/112067210701700602","type":"journal-article","created":{"date-parts":[[2018,1,19]],"date-time":"2018-01-19T00:45:08Z","timestamp":1516322708000},"page":"879-884","source":"Crossref","is-referenced-by-count":14,"title":["Cyclooxygenase-2 Expression in Primary and Recurrent Pterygium"],"prefix":"10.1177","volume":"17","author":[{"given":"U.","family":"Adiguzel","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Mersin University School of Medicine, Mersin - Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Karabacak","sequence":"additional","affiliation":[{"name":"Department of Pathology, Mersin University School of Medicine, Mersin - Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Sari","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Mersin University School of Medicine, Mersin - Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Oz","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Mersin University School of Medicine, Mersin - Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Cinel","sequence":"additional","affiliation":[{"name":"Department of Pathology, Mersin University School of Medicine, Mersin - 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