{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:05:10Z","timestamp":1777579510525,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To compare the effectiveness of two treatment sequences, latanoprost\u2013latanoprost timolol fixed combination (L-LT) versus travoprost\u2013travoprost timolol fixed combination (T-TT), in the treatment of open-angle glaucoma (OAG) or ocular hypertension (OHT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A discrete event simulation (DES) model was constructed. Patients with either OAG or OHT were treated first-line with a prostaglandin, either latanoprost or travoprost. In case of treatment failure, patients were switched to the specific prostaglandin-timolol sequence LT or TT. Failure was defined as intraocular pressure higher than or equal to 18 mmHg at two visits. Time to failure was estimated from two randomized clinical trials. Log-rank tests were computed. Linear functions after log-log transformation were used to model time to failure. The time horizon of the model was 60 months. Outcomes included treatment failure and disease progression. Sensitivity analyses were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Latanoprost treatment resulted in more treatment failures than travoprost (p&lt;0.01), and LT more than TT (p&lt;0.01). At 60 months, the probability of starting a third treatment line was 39.2% with L-LT versus 29.9% with T-TT. On average, L-LT patients developed 0.55 new visual field defects versus 0.48 for T-TT patients. The probability of no disease progression at 60 months was 61.4% with L-LT and 65.5% with T-TT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Based on randomized clinical trial results and using a DES model, the T-TT sequence was more effective at avoiding starting a third line treatment than the L-LT sequence. T-TT treated patients developed less glaucoma progression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/112067210801800108","type":"journal-article","created":{"date-parts":[[2018,1,19]],"date-time":"2018-01-19T00:49:40Z","timestamp":1516322980000},"page":"44-51","source":"Crossref","is-referenced-by-count":5,"title":["Treatment Carryover Impacts on Effectiveness of Intraocular Pressure Lowering Agents, Estimated by a Discrete Event Simulation Model"],"prefix":"10.1177","volume":"18","author":[{"given":"P.","family":"Denis","sequence":"first","affiliation":[{"name":"H\u00f4pital Edouard Herriot, Lyon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Le Pen","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Dauphine, Paris"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Umuhire","sequence":"additional","affiliation":[{"name":"Aremis, Neuilly-sur-Seine, Paris"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Berdeaux","sequence":"additional","affiliation":[{"name":"Alcon France, Rueil-Malmaison"},{"name":"Conservatoire National des Arts et M\u00e9tiers, Paris - France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,1,18]]},"reference":[{"key":"bibr1-112067210801800108","first-page":"1268","volume":"120","author":"Leske M.V.","year":"2002","journal-title":"Acta Ophthalmol"},{"key":"bibr2-112067210801800108","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(00)00538-9"},{"key":"bibr3-112067210801800108","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.120.6.714"},{"key":"bibr4-112067210801800108","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0420.2001.079002121.x"},{"key":"bibr5-112067210801800108","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0420.2001.079002116.x"},{"key":"bibr6-112067210801800108","doi-asserted-by":"publisher","DOI":"10.2165\/00044011-200626120-00004"},{"key":"bibr7-112067210801800108","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2005.09.011"},{"key":"bibr8-112067210801800108","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2005.04.051"},{"key":"bibr9-112067210801800108","first-page":"6","author":"Buchan J.C.","year":"2006","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"bibr10-112067210801800108","doi-asserted-by":"publisher","DOI":"10.1089\/jop.2004.20.461"},{"key":"bibr11-112067210801800108","doi-asserted-by":"publisher","DOI":"10.1097\/00061198-200310000-00001"},{"key":"bibr12-112067210801800108","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4733.2001.43040.x"},{"key":"bibr13-112067210801800108","doi-asserted-by":"publisher","DOI":"10.1097\/01.opx.0000249979.36298.40"},{"key":"bibr14-112067210801800108","doi-asserted-by":"publisher","DOI":"10.1007\/BF02600850"},{"key":"bibr15-112067210801800108","doi-asserted-by":"publisher","DOI":"10.2165\/00019053-199507060-00003"},{"key":"bibr16-112067210801800108","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2005.076117"},{"key":"bibr17-112067210801800108","doi-asserted-by":"publisher","DOI":"10.1097\/00061198-200106000-00007"},{"key":"bibr18-112067210801800108","doi-asserted-by":"publisher","DOI":"10.1023\/A:1002453604171"},{"key":"bibr19-112067210801800108","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0420.2001.790315.x"},{"key":"bibr20-112067210801800108","volume-title":"Differences in international treatment patterns and costs. Ed. Isis.","author":"Jonsson B.","year":"1999"},{"key":"bibr21-112067210801800108","doi-asserted-by":"publisher","DOI":"10.1097\/00061198-199804000-00006"},{"key":"bibr22-112067210801800108","doi-asserted-by":"publisher","DOI":"10.1097\/00061198-200408000-00005"},{"key":"bibr23-112067210801800108","doi-asserted-by":"publisher","DOI":"10.1177\/112067210601600115"},{"key":"bibr24-112067210801800108","doi-asserted-by":"publisher","DOI":"10.1185\/030079905X38169"},{"key":"bibr25-112067210801800108","doi-asserted-by":"publisher","DOI":"10.1185\/030079904125004358"},{"key":"bibr26-112067210801800108","doi-asserted-by":"publisher","DOI":"10.1097\/00061198-200312000-00002"},{"key":"bibr27-112067210801800108","doi-asserted-by":"publisher","DOI":"10.1185\/030079907X178720"},{"key":"bibr28-112067210801800108","first-page":"472","volume":"132","author":"Netland P.A.","year":"2001","journal-title":"Travoprost compared with latanoprost and timolol in patients with open-angle glaucoma or ocular hypertension, Am J Ophthalmol"},{"issue":"17","key":"bibr29-112067210801800108","first-page":"183","volume":"2","author":"Topouzis F.","year":"2007","journal-title":"Eur J Glaucoma"},{"key":"bibr30-112067210801800108","doi-asserted-by":"publisher","DOI":"10.2165\/00019053-200523040-00003"},{"key":"bibr31-112067210801800108","doi-asserted-by":"publisher","DOI":"10.2165\/00044011-200424060-00004"},{"key":"bibr32-112067210801800108","doi-asserted-by":"publisher","DOI":"10.1097\/01.ijg.0000184834.93535.0b"},{"key":"bibr33-112067210801800108","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2005.01.042"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/112067210801800108","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/112067210801800108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:37:44Z","timestamp":1777405064000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/112067210801800108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["10.1177\/112067210801800108"],"URL":"https:\/\/doi.org\/10.1177\/112067210801800108","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,1]]}}}