{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T15:21:42Z","timestamp":1779117702099,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Leber hereditary optic neuropathy (LHON) is recognized as the most common cause of isolated blindness in young men. The current study was designed to test whether LHON as a mitochondrial disease is associated with vascular functional alterations characterized by aortic elastic properties during echocardiography.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 19 patients with typical features of LHON aged 42\u00b113 years (10 males) were included. Their results were compared to 19 age- and gender-matched healthy controls. Aortic stiffness index was calculated from the echocardiographically derived aortic diameters and the clinical blood pressure data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In this patient population, the point mutation was present in 3460G&gt;A position in five cases, in 11778G&gt;A position in five cases, and in 14484T&gt;C position in nine patients. Diastolic aortic diameter (26.0\u00b12.5 mm vs 28.4\u00b14.1 mm, pp&lt;0.05) and aortic stiffness index (5.1\u00b12.6 vs 12.0\u00b17.9, pp&lt;0.05) were significantly increased in LHON patients compared to controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Aortic stiffness can be increased in LHON disease, but further studies are warranted to confirm these findings in a larger LHON patient population with a more reliable method focusing on the pathophysiologic background.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/112067210801800225","type":"journal-article","created":{"date-parts":[[2018,1,19]],"date-time":"2018-01-19T00:48:34Z","timestamp":1516322914000},"page":"309-312","source":"Crossref","is-referenced-by-count":3,"title":["Is There Alteration in Aortic Stiffness in Leber Hereditary Optic Neuropathy?"],"prefix":"10.1177","volume":"18","author":[{"given":"A.","family":"Nemes","sequence":"first","affiliation":[{"name":"Department of Cardiology, Thoraxcentre, Erasmus Medical Center, Rotterdam - The Netherlands"},{"name":"2nd Department of Medicine and Cardiology Center, University of Szeged, Szeged - Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.F.M.","family":"De Coo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Erasmus Medical Center, Rotterdam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Spruijt","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, Radboud University Nijmegen Medical Center, Nijmegen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.J.M.","family":"Smeets","sequence":"additional","affiliation":[{"name":"Research Institute Growth and Development (GROW), University of Maastricht, Maastricht - The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.F.","family":"Chinnery","sequence":"additional","affiliation":[{"name":"Mitochondrial Research Group, The Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne - England"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.I.I.","family":"Soliman","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Thoraxcentre, Erasmus Medical Center, Rotterdam - The Netherlands"},{"name":"Department of Cardiology, Al-Hussein University Hospital, Al-Azhar University, Cairo - Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.L.","family":"Geleijnse","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Thoraxcentre, Erasmus Medical Center, Rotterdam - The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.J.","family":"Ten Cate","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Thoraxcentre, Erasmus Medical Center, Rotterdam - The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,1,18]]},"reference":[{"key":"bibr1-112067210801800225","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1983.01040020061011"},{"key":"bibr2-112067210801800225","first-page":"348","volume":"24","author":"Erickson R.P.","year":"1972","journal-title":"Am J Hum Genet"},{"key":"bibr3-112067210801800225","doi-asserted-by":"publisher","DOI":"10.1016\/0921-8734(92)90021-G"},{"key":"bibr4-112067210801800225","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1991.03470130092035"},{"key":"bibr5-112067210801800225","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2006.08.025"},{"key":"bibr6-112067210801800225","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a059639"},{"key":"bibr7-112067210801800225","doi-asserted-by":"publisher","DOI":"10.1126\/science.3201231"},{"key":"bibr8-112067210801800225","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2362.1999.00540.x"},{"key":"bibr9-112067210801800225","doi-asserted-by":"publisher","DOI":"10.1177\/0961203306071402"},{"key":"bibr10-112067210801800225","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh607"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/112067210801800225","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/112067210801800225","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:37:53Z","timestamp":1777405073000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/112067210801800225"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["10.1177\/112067210801800225"],"URL":"https:\/\/doi.org\/10.1177\/112067210801800225","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3]]}}}